Effects of datumetine on hippocampal NMDAR activity
Datumetine binds with NMDAR altering its calcium current. Acute exposure downregulates NMDAR signalling. [Display omitted] •Datura intoxication induces an amnesic experience.•N-methyl-d-aspartate receptor (NMDAR) is implicated in-memory processing.•Flexible docking showed datumetine binds with NMDAR...
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Published in | Toxicology reports Vol. 8; pp. 1131 - 1142 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
01.01.2021
Elsevier |
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Abstract | Datumetine binds with NMDAR altering its calcium current. Acute exposure downregulates NMDAR signalling.
[Display omitted]
•Datura intoxication induces an amnesic experience.•N-methyl-d-aspartate receptor (NMDAR) is implicated in-memory processing.•Flexible docking showed datumetine binds with NMDAR.•Datumetine alters hippocampal NMDAR electrical activity.•Acute datumetine exposure alters NMDAR biological activity.
The usage (abuse) of Datura metel is becoming increasingly worrisome among the Nigerian populace especially among the youth considering its side effects such as hallucination. This work was designed to identify the phytochemicals in datura plant that potentially interact with NMDAR as it affects the electrical and memory activities of the brain.
Ligand-protein interaction was assessed using autodock vina to identify phytochemicals that can interact with NMDAR. Datumetine was found to have the best interaction fit with NMDAR at both allosteric and orthosteric binding sites. Furthermore, using electrophysiological, behavioural and western blotting techniques, it was observed that the administration of datumetine positively modulates the NMDAR current by prolonging burst duration and interspike interval, induces seizures in C57BL/6 mice. Acute exposure leads to memory deficit on NOR and Y-maze test while immunoblotting results showed increased expression of GluN1 and CamKIIα while pCamKIIα-T286, CREB and BDNF were downregulated. The results showed that the memory deficit seen in datura intoxication is possibly the effects of datumetine on NMDAR. |
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AbstractList | The usage (abuse) of Datura metel is becoming increasingly worrisome among the Nigerian populace especially among the youth considering its side effects such as hallucination. This work was designed to identify the phytochemicals in datura plant that potentially interact with NMDAR as it affects the electrical and memory activities of the brain.Ligand-protein interaction was assessed using autodock vina to identify phytochemicals that can interact with NMDAR. Datumetine was found to have the best interaction fit with NMDAR at both allosteric and orthosteric binding sites. Furthermore, using electrophysiological, behavioural and western blotting techniques, it was observed that the administration of datumetine positively modulates the NMDAR current by prolonging burst duration and interspike interval, induces seizures in C57BL/6 mice. Acute exposure leads to memory deficit on NOR and Y-maze test while immunoblotting results showed increased expression of GluN1 and CamKIIα while pCamKIIα-T286, CREB and BDNF were downregulated. The results showed that the memory deficit seen in datura intoxication is possibly the effects of datumetine on NMDAR. Datumetine binds with NMDAR altering its calcium current. Acute exposure downregulates NMDAR signalling. • Datura intoxication induces an amnesic experience. • N -methyl- d -aspartate receptor (NMDAR) is implicated in-memory processing. • Flexible docking showed datumetine binds with NMDAR. • Datumetine alters hippocampal NMDAR electrical activity. • Acute datumetine exposure alters NMDAR biological activity. The usage (abuse) of Datura metel is becoming increasingly worrisome among the Nigerian populace especially among the youth considering its side effects such as hallucination. This work was designed to identify the phytochemicals in datura plant that potentially interact with NMDAR as it affects the electrical and memory activities of the brain. Ligand-protein interaction was assessed using autodock vina to identify phytochemicals that can interact with NMDAR. Datumetine was found to have the best interaction fit with NMDAR at both allosteric and orthosteric binding sites. Furthermore, using electrophysiological, behavioural and western blotting techniques, it was observed that the administration of datumetine positively modulates the NMDAR current by prolonging burst duration and interspike interval, induces seizures in C57BL/6 mice. Acute exposure leads to memory deficit on NOR and Y-maze test while immunoblotting results showed increased expression of GluN1 and CamKIIα while pCamKIIα-T286, CREB and BDNF were downregulated. The results showed that the memory deficit seen in datura intoxication is possibly the effects of datumetine on NMDAR. Datumetine binds with NMDAR altering its calcium current. Acute exposure downregulates NMDAR signalling. [Display omitted] •Datura intoxication induces an amnesic experience.•N-methyl-d-aspartate receptor (NMDAR) is implicated in-memory processing.•Flexible docking showed datumetine binds with NMDAR.•Datumetine alters hippocampal NMDAR electrical activity.•Acute datumetine exposure alters NMDAR biological activity. The usage (abuse) of Datura metel is becoming increasingly worrisome among the Nigerian populace especially among the youth considering its side effects such as hallucination. This work was designed to identify the phytochemicals in datura plant that potentially interact with NMDAR as it affects the electrical and memory activities of the brain. Ligand-protein interaction was assessed using autodock vina to identify phytochemicals that can interact with NMDAR. Datumetine was found to have the best interaction fit with NMDAR at both allosteric and orthosteric binding sites. Furthermore, using electrophysiological, behavioural and western blotting techniques, it was observed that the administration of datumetine positively modulates the NMDAR current by prolonging burst duration and interspike interval, induces seizures in C57BL/6 mice. Acute exposure leads to memory deficit on NOR and Y-maze test while immunoblotting results showed increased expression of GluN1 and CamKIIα while pCamKIIα-T286, CREB and BDNF were downregulated. The results showed that the memory deficit seen in datura intoxication is possibly the effects of datumetine on NMDAR. |
Author | Ishola, Azeez Olakunle Ajao, Moyosore Salihu Imam, Aminu |
Author_xml | – sequence: 1 givenname: Azeez Olakunle surname: Ishola fullname: Ishola, Azeez Olakunle organization: Department of Anatomy, University of Ilorin, Ilorin, Nigeria – sequence: 2 givenname: Aminu surname: Imam fullname: Imam, Aminu organization: Department of Anatomy, University of Ilorin, Ilorin, Nigeria – sequence: 3 givenname: Moyosore Salihu surname: Ajao fullname: Ajao, Moyosore Salihu email: moyoajao@unilorin.edu.ng organization: Department of Anatomy, University of Ilorin, Ilorin, Nigeria |
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CitedBy_id | crossref_primary_10_1186_s42826_023_00162_7 crossref_primary_10_1016_j_crtox_2023_100106 crossref_primary_10_1021_jacsau_3c00472 |
Cites_doi | 10.1523/JNEUROSCI.5115-09.2010 10.1002/jnr.21554 10.1126/science.1086446 10.1016/j.neuron.2010.12.004 10.1002/jcc.21334 10.1002/jcc.21256 10.1016/0304-3940(89)90618-6 10.1023/B:NERE.0000035805.46592.6c 10.1152/jn.1990.64.1.119 10.1038/npp.2013.60 10.1016/j.expneurol.2008.01.030 10.1038/sj.mp.4002130 10.1126/science.1090842 10.1038/nrn2911 10.1038/jcbfm.2010.18 10.1523/JNEUROSCI.2672-10.2011 10.4236/wjns.2015.54026 10.1124/pr.109.002451 10.1001/jama.2011.1590 10.1016/j.neuropharm.2013.01.012 10.1093/sleep/zsx166 10.1016/0031-9422(93)85378-5 10.1016/0092-8674(86)90008-5 10.4323/rjlm.2016.308 10.5455/jva.20150401025957 10.1523/JNEUROSCI.3607-06.2007 10.1016/j.tins.2012.05.003 10.1371/journal.pone.0062235 10.1371/journal.pone.0037916 10.1002/hlca.200790159 10.1016/j.neuint.2008.07.007 10.1080/02791072.2010.10400713 10.1016/S0166-2236(96)80026-9 10.1523/JNEUROSCI.21-05-01501.2001 10.1016/j.jmb.2011.11.008 10.1021/np070096b 10.1098/rstb.2013.0131 10.1016/j.neures.2005.06.008 10.1016/j.neuropharm.2011.07.036 10.1007/s11515-011-1187-6 10.18632/oncotarget.25169 10.1016/j.pbb.2006.11.021 10.1016/j.yebeh.2011.07.024 10.18356/d29e3f27-en 10.1016/j.supflu.2015.10.016 10.1038/nrn3192 10.1016/S0896-6273(01)00561-X 10.1007/978-1-4614-7320-6_339-1 10.1016/0006-8993(80)90226-7 10.1038/sj.npp.1301276 10.1016/j.neuron.2004.09.012 10.1016/j.neubiorev.2017.02.024 10.1007/s00422-009-0298-5 10.1016/j.biomag.2010.10.006 10.1016/j.wem.2016.04.007 10.1016/j.compbiolchem.2018.06.005 10.1113/jphysiol.2004.063982 10.1002/jnr.24251 10.1016/j.celrep.2014.01.005 10.1016/j.neuint.2014.09.007 10.1016/j.neurobiolaging.2015.02.003 10.1016/j.neulet.2006.03.028 10.3390/molecules19044548 10.1074/jbc.M113.482000 10.1038/nrd1549 10.1016/S0014-5793(99)00985-0 10.1101/cshperspect.a005710 10.1016/S2221-1691(13)60014-3 10.1038/32448 10.1016/j.pneurobio.2018.10.001 10.1016/j.neuropharm.2019.107783 10.1002/hipo.10193 10.3923/biotech.2004.109.113 10.1016/j.supflu.2015.04.008 10.1073/pnas.1932759100 10.1196/annals.1300.016 10.1016/j.mcn.2011.02.003 10.4314/ijbcs.v11i5.1 10.1042/BST0371369 10.1038/sj.tpj.6500265 10.1007/s12272-001-1274-6 10.1523/JNEUROSCI.1469-10.2010 10.1016/j.neuroscience.2018.09.018 10.1016/S0896-6273(01)00194-5 10.1016/j.neuron.2005.08.034 10.1007/s00726-009-0315-y 10.1016/j.neuropharm.2016.03.004 10.1016/j.steroids.2014.05.003 10.1016/j.jep.2003.12.010 10.1073/pnas.0601899103 10.1016/j.jksus.2013.07.002 10.1016/j.biopsych.2007.03.017 |
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Keywords | NMDAR Docking Datura Datumetine Hippocampus |
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References | Gupta, Sharma, Kumar (bib0180) 2018; 76 Vasquez, Riener, Reynolds, Britton (bib0365) 2014; 79 Tao, West, Chen, Corfas, Greenberg (bib0510) 2002; 33 Abena, Miguel, Mouanga, Ouamba, Sianard, Thiebolt, Hondi-Assah, Diatewa (bib0260) 2004; 3 Tian, Marini, Lipsky (bib0525) 2010; 38 Barria, Malinow (bib0415) 2005; 48 Lau, Takeuchi, Rodenas-Ruano, Takayasu, Murphy, Bennett, Zukin (bib0235) 2009; 37 Roberto, Siggins (bib0295) 2006; 103 Renteria, Maier, Buske, Morrisett (bib0380) 2017; 112 Gronli, Bramham, Murison, Kanhema, Fiske, Bjorvatn (bib0560) 2006; 85 Kuang, Yang, Xia, Feng (bib0145) 2008; 31 Murthy, Nammi, Kota, Krishna Rao, Koteswara, Annapurna (bib0170) 2004; 91 Rodriguez-Munoz, Sanchez-Blazquez, Garzon (bib0445) 2018; 9 Sabatier, Brown, Ludwig, Leng (bib0205) 2004; 558 Prasad, Gowda (bib0080) 2005; 58 Coultrap, Bayer (bib0340) 2012; 35 Al-Snafi (bib0030) 2017; 7 Soni, Siddiqui, Dwivedi, Soni (bib0060) 2012; 2 Gerges, Aleisa, Schwarz, Alkadhi (bib0360) 2004; 14 Durak, Aysu (bib0040) 2016; 108 Shresta, Sultana, Lee, Ogundele (bib0120) 2019; 11 Traynelis, Wollmuth, McBain, Menniti, Vance, Ogden, Hansen, Yuan, Myers, Dingledine (bib0285) 2010; 62 Hilal, Alabri, Hamood, Musalami, Hossain, Weli, Al-Riyami (bib0095) 2014; 26 Jain, Baitharu, Prasad, Ilavazhagan (bib0580) 2013; 8 Stella, Vitelli, Palazzo, Oliva, De Novellis, Capuano, Scafuro, Berrino, Rossi, Maione (bib0045) 2010; 42 Alasmari, Goodwari, McCullumsmith, Sari (bib0310) 2018; 171 Sanacora, Treccani, Popoli (bib0325) 2012; 62 United Nations Office on Drugs and Crime UNODC (bib0015) 2017 Ashpole, Hudmon (bib0455) 2011; 46 Kiruthika, Sornaraj (bib0150) 2011; 3 Park, Lee, Kim, Yoon, Kim (bib0570) 2006; 402 Martinowich, Hattori, Wu, Fouse, He, Hu (bib0520) 2003; 302 Gardoni, Schrama, van Dalen, Gispen, Cattabeni, Di Luca (bib0390) 1999; 456 Sasaki, Takemori, Yagita, Terasaki, Uebi, Horike, Takagi, Susumu, Teraoka, Kusano, Hatano, Oyama, Sugiyama, Sakoda, Kitagawa (bib0495) 2011; 69 Ghasemi, Schacter (bib0250) 2011; 22 Barlett, Wang (bib0350) 2013; 74 Qi, Liu, Zhang, Gao, Li, Chen, Lin, Wang, Wang, Tang, Chen (bib0375) 2020; 162 Xu, Luo, Richardson, Li (bib0540) 2004; 4 Ndinda (bib0005) 2018 Morris, Huey, Lindstrom, Sanner, Belew, Goodsell, Olson (bib0115) 2009; 16 Miller, Kennedy (bib0420) 1986; 44 Song, Feng, Zhang, Xia, Ji, Lv, Ping (bib0200) 2017; 40 Etibor, Ajibola, Buhari, Safiriyu, Akinola, Caxton-Martins (bib0280) 2015; 5 Yang, Guo, Li, Wu, Zhang, Liu, Wang, Kuang (bib0160) 2014; 87 Calabrese, Guidotti, Molteni, Racagni, Mancini, Riva (bib0425) 2012; 7 Leveille, Papadia, Fricker, Bell, Soriano, Martel, Puddifoot, Habel, Wyllie, Ikonomidou, Tolkovsky, Hardingham (bib0460) 2010; 30 Tόth, Cutsuridis (bib0195) 2010 Hardingham, Bading (bib0465) 2010; 11 Aysu, Durak (bib0035) 2015; 102 Khaleque, Akm, Ismail, Sadrul Amin, Kiamuddin (bib0125) 1974; 9 Li, Zhou, Liu, Liu, Geng, Weng (bib0545) 2013; 2013 Sah (bib0215) 1996; 19 Yang, Wang, Xia, Feng, Kuang (bib0140) 2007; 90 Lambert, Jones (bib0190) 1990; 64 Olawepo, Ishola, Ajao, Olayemi, Olayaki (bib0255) 2017; 11 Zhou, Ding, Chen, Yun, Wang (bib0500) 2013; 288 Murakami, Imbe, Morikawa, Kubo, Senba (bib0535) 2005; 53 Chen, Chang, Lin, Meissner, West, Griffith (bib0515) 2003; 302 Donatus, Ephraim (bib0070) 2009; 3 Benda, Tabak (bib0210) 2014 Paul, Skolnick (bib0330) 2003; 1003 Lűscher, Malenka (bib0240) 2012; 4 Kitchen, Decornez, Furr, Bajorath (bib0175) 2004; 3 Manickam, Sinha-Bagchi, Sinha, Gupta, Ray (bib0130) 1993; 34 Chen, Rosner, Hankinson, Colditz, Willett (bib0305) 2011; 306 Terasaki, Sasaki, Yagita, Okazaki, Sugiyama, Oyama, Kitagawa (bib0490) 2010; 30 Easton, Lucchesi, Lourdusamy, Lenz, Solati, Golub, Lewczuk, Fernandes, Desriveres, Dawirs, Moll, Kornhuber, Frank, Hoffmann, Soyka, Kiefer, The GESGA Consortium, Schumann, Giese, Muller (bib0385) 2013; 38 Bradshaw, Kubota, Meyer, Schulman (bib0440) 2003; 100 Sun, Xu, Cheng, Chen, Xie, Zhang, Wang, Hu, Gao (bib0480) 2018; 96 Lan, McLoughlin, Griffin, Tsang, Huang, Yuan, Manji, Holmes, Bahn (bib0320) 2009; 14 Lee, Silverman, Hansen, Patel, Manchikanti (bib0370) 2011; 14 Pan, Wang, Hu (bib0135) 2007; 70 Nair, Vadodaria, Banerjee, Benekareddy, Dias, Duman (bib0550) 2007; 32 Luo, Wu, Chen (bib0505) 2011; 6 Chen, He, Hu, Yu, Zhou, Zheng (bib0530) 2007; 27 Han, Wang, Zhang, Tan, Wang (bib0165) 2015; 38 Sutherland, Doiron, Longtin (bib0220) 2009; 100 Zhang, Buchthal, Lau, Hayer, Dick, Schwaninger, Veltkamp, Zou, Weiss, Bading (bib0470) 2011; 31 McNaughton (bib0225) 1980; 199 Kennedy (bib0410) 2010; vol. 3 Fontella, Vendite, Tabajara, Porciuncula, da Silva Torres, Jardim (bib0355) 2004; 29 Valera, Sanchez-Martin, Ferrer-Montiel, Messeguer, Merino (bib0485) 2008; 53 Yang, Guo, Li, Lin, Wang, Shu, Wang, Zhang, Xia, Jiang, Wang, Kuang (bib0155) 2014; 19 Babalola, Sulaiman, Hassan, Adawa (bib0265) 2013; a6 Babalola, Suleiman, Hassan, Adawa (bib0275) 2015; 5 Allaman, Papp, Kraftsik, Fiumelli, Magistretti, Martin (bib0565) 2008; 60 Trott, Olson (bib0110) 2010; 31 Hota, Barhwal, Singh, Sairam, Ilavazhagan (bib0590) 2008; 86 Arefi, Barzegari, Asgari, Soltani, Farhidnia, Fallah (bib0050) 2016; 24 Malami, Alhassan (bib0100) 2014; 9 Xiao, Shu, Tang, Wang, Liu, Wang (bib0555) 2011; 1 Rumi-Masante, Rusinga, Lester, Dunlap, Williams, Dunker (bib0435) 2012; 415 Kanchan, Atreya (bib0090) 2016; 27 Li, Stefan, Le Nove (bib0430) 2012; 7 Hashimoto, Sawa, Iyo (bib0315) 2007; 62 Lambert, Jones (bib0185) 1989; 97 Buard, Coultrap, Freund, Lee, Dell’Acqua, Silva, Bayer (bib0450) 2010; 30 Lisman, Yasuda, Raghavachari (bib0400) 2014; 13 Jamdhade, Survase, Kare, Bhuktar (bib0020) 2010; 2 Ganesh, Radha, Jayshree (bib0025) 2015; 2 Goodwani, Saternos, Alasmari, Sari (bib0300) 2017; 77 Maheshwari, Khan, Chopade (bib0105) 2013; 7 Park, Volianskis, Sanderson, Bortolotto, Jane, Zhuo, Kaang, Collingridge (bib0245) 2014; 369 Gan, Qi, Mao, Liu (bib0290) 2013; 8 Yussuf (bib0065) 1991; 29 Gardoni, Schrama, Kamal, Gispen, Cattabeni, Di Luca (bib0395) 2001; 21 Coultrap, Freund, O’Leary, Sanderson, Roche, Dell’Acqua, Bayer (bib0405) 2014; 6 Cristino, Luongo, Squillace, Paolone, Mango, Piccinin, Zianni, Imperatore, Iannotta, Longo, Errico, Vescovi, Morari, Maione, Gardoni, Nistico, Usiello (bib0335) 2015; 36 Hota, Barhwal, Singh, Ilavazhagan (bib0585) 2008; 212 Deepa, Sugitha, Mythili, Sathiavelu (bib0270) 2014; 6 Malenka, Bear (bib0345) 2004; 44 Deisseroth, Heist, Tsien (bib0475) 1998; 392 Devi, Bawari, Paul, Sharma (bib0085) 2011; 7 Moses (bib0055) 2010 United Nations Office on Drugs and Crime UNODC (bib0010) 2018 Lu, Man, Ju, Trimble, MacDonald, Wang (bib0230) 2001; 29 Katzung, Masters, Trevor (bib0075) 2009 Das, Biswal, Barhwal, Chaurasia, Hota (bib0575) 2018; 39 Lan (10.1016/j.toxrep.2021.05.009_bib0320) 2009; 14 Ghasemi (10.1016/j.toxrep.2021.05.009_bib0250) 2011; 22 Sabatier (10.1016/j.toxrep.2021.05.009_bib0205) 2004; 558 Alasmari (10.1016/j.toxrep.2021.05.009_bib0310) 2018; 171 Hota (10.1016/j.toxrep.2021.05.009_bib0590) 2008; 86 Xu (10.1016/j.toxrep.2021.05.009_bib0540) 2004; 4 Lu (10.1016/j.toxrep.2021.05.009_bib0230) 2001; 29 Park (10.1016/j.toxrep.2021.05.009_bib0570) 2006; 402 Das (10.1016/j.toxrep.2021.05.009_bib0575) 2018; 39 Gronli (10.1016/j.toxrep.2021.05.009_bib0560) 2006; 85 Jain (10.1016/j.toxrep.2021.05.009_bib0580) 2013; 8 Hota (10.1016/j.toxrep.2021.05.009_bib0585) 2008; 212 Durak (10.1016/j.toxrep.2021.05.009_bib0040) 2016; 108 Khaleque (10.1016/j.toxrep.2021.05.009_bib0125) 1974; 9 Yang (10.1016/j.toxrep.2021.05.009_bib0155) 2014; 19 Sun (10.1016/j.toxrep.2021.05.009_bib0480) 2018; 96 Yussuf (10.1016/j.toxrep.2021.05.009_bib0065) 1991; 29 Lambert (10.1016/j.toxrep.2021.05.009_bib0190) 1990; 64 Qi (10.1016/j.toxrep.2021.05.009_bib0375) 2020; 162 Miller (10.1016/j.toxrep.2021.05.009_bib0420) 1986; 44 Donatus (10.1016/j.toxrep.2021.05.009_bib0070) 2009; 3 Rumi-Masante (10.1016/j.toxrep.2021.05.009_bib0435) 2012; 415 Devi (10.1016/j.toxrep.2021.05.009_bib0085) 2011; 7 Barria (10.1016/j.toxrep.2021.05.009_bib0415) 2005; 48 Trott (10.1016/j.toxrep.2021.05.009_bib0110) 2010; 31 Martinowich (10.1016/j.toxrep.2021.05.009_bib0520) 2003; 302 Chen (10.1016/j.toxrep.2021.05.009_bib0515) 2003; 302 Bradshaw (10.1016/j.toxrep.2021.05.009_bib0440) 2003; 100 Rodriguez-Munoz (10.1016/j.toxrep.2021.05.009_bib0445) 2018; 9 Ganesh (10.1016/j.toxrep.2021.05.009_bib0025) 2015; 2 Terasaki (10.1016/j.toxrep.2021.05.009_bib0490) 2010; 30 Prasad (10.1016/j.toxrep.2021.05.009_bib0080) 2005; 58 Ndinda (10.1016/j.toxrep.2021.05.009_bib0005) 2018 Aysu (10.1016/j.toxrep.2021.05.009_bib0035) 2015; 102 Katzung (10.1016/j.toxrep.2021.05.009_bib0075) 2009 Shresta (10.1016/j.toxrep.2021.05.009_bib0120) 2019; 11 Deepa (10.1016/j.toxrep.2021.05.009_bib0270) 2014; 6 United Nations Office on Drugs and Crime UNODC (10.1016/j.toxrep.2021.05.009_bib0010) 2018 Buard (10.1016/j.toxrep.2021.05.009_bib0450) 2010; 30 Lee (10.1016/j.toxrep.2021.05.009_bib0370) 2011; 14 McNaughton (10.1016/j.toxrep.2021.05.009_bib0225) 1980; 199 Zhang (10.1016/j.toxrep.2021.05.009_bib0470) 2011; 31 Tian (10.1016/j.toxrep.2021.05.009_bib0525) 2010; 38 Barlett (10.1016/j.toxrep.2021.05.009_bib0350) 2013; 74 Luo (10.1016/j.toxrep.2021.05.009_bib0505) 2011; 6 Renteria (10.1016/j.toxrep.2021.05.009_bib0380) 2017; 112 Stella (10.1016/j.toxrep.2021.05.009_bib0045) 2010; 42 Valera (10.1016/j.toxrep.2021.05.009_bib0485) 2008; 53 Han (10.1016/j.toxrep.2021.05.009_bib0165) 2015; 38 Abena (10.1016/j.toxrep.2021.05.009_bib0260) 2004; 3 Paul (10.1016/j.toxrep.2021.05.009_bib0330) 2003; 1003 Gardoni (10.1016/j.toxrep.2021.05.009_bib0395) 2001; 21 Malenka (10.1016/j.toxrep.2021.05.009_bib0345) 2004; 44 Yang (10.1016/j.toxrep.2021.05.009_bib0160) 2014; 87 Murakami (10.1016/j.toxrep.2021.05.009_bib0535) 2005; 53 Fontella (10.1016/j.toxrep.2021.05.009_bib0355) 2004; 29 Babalola (10.1016/j.toxrep.2021.05.009_bib0275) 2015; 5 Lisman (10.1016/j.toxrep.2021.05.009_bib0400) 2014; 13 Moses (10.1016/j.toxrep.2021.05.009_bib0055) 2010 Etibor (10.1016/j.toxrep.2021.05.009_bib0280) 2015; 5 Tόth (10.1016/j.toxrep.2021.05.009_bib0195) 2010 Gan (10.1016/j.toxrep.2021.05.009_bib0290) 2013; 8 Benda (10.1016/j.toxrep.2021.05.009_bib0210) 2014 Kennedy (10.1016/j.toxrep.2021.05.009_bib0410) 2010; vol. 3 Tao (10.1016/j.toxrep.2021.05.009_bib0510) 2002; 33 United Nations Office on Drugs and Crime UNODC (10.1016/j.toxrep.2021.05.009_bib0015) 2017 Sah (10.1016/j.toxrep.2021.05.009_bib0215) 1996; 19 Morris (10.1016/j.toxrep.2021.05.009_bib0115) 2009; 16 Murthy (10.1016/j.toxrep.2021.05.009_bib0170) 2004; 91 Traynelis (10.1016/j.toxrep.2021.05.009_bib0285) 2010; 62 Li (10.1016/j.toxrep.2021.05.009_bib0545) 2013; 2013 Gardoni (10.1016/j.toxrep.2021.05.009_bib0390) 1999; 456 Gerges (10.1016/j.toxrep.2021.05.009_bib0360) 2004; 14 Xiao (10.1016/j.toxrep.2021.05.009_bib0555) 2011; 1 Calabrese (10.1016/j.toxrep.2021.05.009_bib0425) 2012; 7 Song (10.1016/j.toxrep.2021.05.009_bib0200) 2017; 40 Maheshwari (10.1016/j.toxrep.2021.05.009_bib0105) 2013; 7 Gupta (10.1016/j.toxrep.2021.05.009_bib0180) 2018; 76 Deisseroth (10.1016/j.toxrep.2021.05.009_bib0475) 1998; 392 Manickam (10.1016/j.toxrep.2021.05.009_bib0130) 1993; 34 Hardingham (10.1016/j.toxrep.2021.05.009_bib0465) 2010; 11 Soni (10.1016/j.toxrep.2021.05.009_bib0060) 2012; 2 Hilal (10.1016/j.toxrep.2021.05.009_bib0095) 2014; 26 Lau (10.1016/j.toxrep.2021.05.009_bib0235) 2009; 37 Babalola (10.1016/j.toxrep.2021.05.009_bib0265) 2013; a6 Allaman (10.1016/j.toxrep.2021.05.009_bib0565) 2008; 60 Nair (10.1016/j.toxrep.2021.05.009_bib0550) 2007; 32 Hashimoto (10.1016/j.toxrep.2021.05.009_bib0315) 2007; 62 Coultrap (10.1016/j.toxrep.2021.05.009_bib0340) 2012; 35 Vasquez (10.1016/j.toxrep.2021.05.009_bib0365) 2014; 79 Ashpole (10.1016/j.toxrep.2021.05.009_bib0455) 2011; 46 Yang (10.1016/j.toxrep.2021.05.009_bib0140) 2007; 90 Kitchen (10.1016/j.toxrep.2021.05.009_bib0175) 2004; 3 Kiruthika (10.1016/j.toxrep.2021.05.009_bib0150) 2011; 3 Lambert (10.1016/j.toxrep.2021.05.009_bib0185) 1989; 97 Park (10.1016/j.toxrep.2021.05.009_bib0245) 2014; 369 Lűscher (10.1016/j.toxrep.2021.05.009_bib0240) 2012; 4 Goodwani (10.1016/j.toxrep.2021.05.009_bib0300) 2017; 77 Coultrap (10.1016/j.toxrep.2021.05.009_bib0405) 2014; 6 Arefi (10.1016/j.toxrep.2021.05.009_bib0050) 2016; 24 Malami (10.1016/j.toxrep.2021.05.009_bib0100) 2014; 9 Sutherland (10.1016/j.toxrep.2021.05.009_bib0220) 2009; 100 Chen (10.1016/j.toxrep.2021.05.009_bib0305) 2011; 306 Sanacora (10.1016/j.toxrep.2021.05.009_bib0325) 2012; 62 Jamdhade (10.1016/j.toxrep.2021.05.009_bib0020) 2010; 2 Roberto (10.1016/j.toxrep.2021.05.009_bib0295) 2006; 103 Al-Snafi (10.1016/j.toxrep.2021.05.009_bib0030) 2017; 7 Sasaki (10.1016/j.toxrep.2021.05.009_bib0495) 2011; 69 Leveille (10.1016/j.toxrep.2021.05.009_bib0460) 2010; 30 Chen (10.1016/j.toxrep.2021.05.009_bib0530) 2007; 27 Zhou (10.1016/j.toxrep.2021.05.009_bib0500) 2013; 288 Pan (10.1016/j.toxrep.2021.05.009_bib0135) 2007; 70 Kanchan (10.1016/j.toxrep.2021.05.009_bib0090) 2016; 27 Kuang (10.1016/j.toxrep.2021.05.009_bib0145) 2008; 31 Cristino (10.1016/j.toxrep.2021.05.009_bib0335) 2015; 36 Easton (10.1016/j.toxrep.2021.05.009_bib0385) 2013; 38 Li (10.1016/j.toxrep.2021.05.009_bib0430) 2012; 7 Olawepo (10.1016/j.toxrep.2021.05.009_bib0255) 2017; 11 |
References_xml | – volume: 46 start-page: 720 year: 2011 end-page: 730 ident: bib0455 article-title: Excitotoxic neuroprotection and vulnerability with CaMKII inhibition publication-title: Mol. Cell. Neurosci. contributor: fullname: Hudmon – volume: 39 start-page: 77 year: 2018 end-page: 91 ident: bib0575 article-title: Kaempferol inhibits extrasynaptic NMDAR mediated downregulation of TRKβ in rat hippocampus during hypoxia publication-title: Neuroscience contributor: fullname: Hota – year: 2017 ident: bib0015 article-title: Global Synthetic Drugs Assessment: Amphetamine-Type Stimulants and New Psychoactive Substances contributor: fullname: United Nations Office on Drugs and Crime UNODC – volume: 77 start-page: 14 year: 2017 end-page: 31 ident: bib0300 article-title: Metabotropic and ionotropic glutamate 5receptors as potential targets for the treatment of alcohol use disorder publication-title: Neurosci. Behav. Rev. contributor: fullname: Sari – volume: 7 start-page: 2885 year: 2013 end-page: 2897 ident: bib0105 article-title: Rediscovering the medicinal properties of Datura sp.: a review publication-title: J. Med. Plants Res. contributor: fullname: Chopade – volume: 26 start-page: 237 year: 2014 end-page: 243 ident: bib0095 article-title: Comparative study of phytochemical screening, antioxidant and antimicrobial capacities of fresh and dry leaves crude plant extracts of Datura metel L publication-title: J. King Saud Univ. - Sci. contributor: fullname: Al-Riyami – volume: 6 start-page: 468 year: 2011 end-page: 476 ident: bib0505 article-title: NMDA receptor signaling: death or survival? publication-title: Front. Biol. contributor: fullname: Chen – volume: 62 start-page: 1310 year: 2007 end-page: 1316 ident: bib0315 article-title: Increased levels of glutamate in brains from patients with mood disorders publication-title: Biol. Psychiatry contributor: fullname: Iyo – volume: 64 start-page: 119 year: 1990 end-page: 132 ident: bib0190 article-title: A reevaluation of excitatory amino acid-mediated synaptic transmission in rat dentate gyrus publication-title: J. Neurophysiol. contributor: fullname: Jones – volume: 53 start-page: 129 year: 2005 end-page: 139 ident: bib0535 article-title: Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly publication-title: Neurosci. Res. contributor: fullname: Senba – volume: 96 start-page: 1430 year: 2018 end-page: 1443 ident: bib0480 article-title: The differences between GluN2A and GluN2B signaling in the brain publication-title: J. Neurosci. Res. contributor: fullname: Gao – volume: 38 start-page: 1636 year: 2013 end-page: 1647 ident: bib0385 article-title: αCaMKII autophosphorylation controls the establishment of alcohol drinking behaviour publication-title: Neuropsychopharmacology contributor: fullname: Muller – volume: 27 start-page: 542 year: 2007 end-page: 552 ident: bib0530 article-title: Differential roles of NR2A- and NR2B-containing NMDA receptors in activity-dependent brain-derived neurotrophic factor gene regulation and limbic epileptogenesis publication-title: J. Neurosci. contributor: fullname: Zheng – volume: 70 start-page: 1127 year: 2007 end-page: 1132 ident: bib0135 article-title: Cytotoxic withanolides from the flowers of publication-title: J. Nat. Prod. contributor: fullname: Hu – volume: 2013 year: 2013 ident: bib0545 article-title: Nobiletin ameliorates the deficits in hippocampal BDNF, TrkB, and synapsin I induced by chronic unpredictable mild stress publication-title: Evid. Complement. Alternat. Med. contributor: fullname: Weng – volume: 22 start-page: 617 year: 2011 end-page: 640 ident: bib0250 article-title: The NMDA receptor complex as a therapeutic target in epilepsy: a review publication-title: Epilepsy Behav. contributor: fullname: Schacter – volume: 97 start-page: 323 year: 1989 end-page: 328 ident: bib0185 article-title: Activation of N-methyl-D-aspartate receptors contributes to the EPSP at perforant path synapses in the rat dentate gyrus in vitro publication-title: Neurosci. Lett. contributor: fullname: Jones – volume: 9 start-page: 1 year: 2014 end-page: 3 ident: bib0100 article-title: Phytochemical evaluation and investigations in to sedative properties of Datura stramonium (Linn) seeds in experimental mice publication-title: IOSR J. Pharm. Biol. Sci. contributor: fullname: Alhassan – volume: 36 start-page: 1890 year: 2015 end-page: 1902 ident: bib0335 article-title: D-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain publication-title: Neurobiol. Aging contributor: fullname: Usiello – volume: 100 start-page: 10512 year: 2003 end-page: 10517 ident: bib0440 article-title: An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signalling publication-title: PNAS contributor: fullname: Schulman – volume: 162 start-page: 107783 year: 2020 ident: bib0375 article-title: Ketamine reduces remifentanil-induced postoperative hyperalgesia mediated by CaMKII-NMDAR in the primary somatosensory cerebral cortex region in mice publication-title: Neuropharmacology contributor: fullname: Chen – volume: 392 start-page: 198 year: 1998 end-page: 202 ident: bib0475 article-title: Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons publication-title: Nature contributor: fullname: Tsien – volume: 16 start-page: 2785 year: 2009 end-page: 2791 ident: bib0115 article-title: Autodock4 and AutoDockTools4: automated docking with selective receptor flexiblity publication-title: J. Comp. Chem. contributor: fullname: Olson – volume: 21 start-page: 1501 year: 2001 end-page: 1509 ident: bib0395 article-title: Hippocampal synaptic plasticity involves competition between Ca2+/calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor publication-title: J. Neurosci. contributor: fullname: Di Luca – volume: 3 start-page: 2025 year: 2011 end-page: 2028 ident: bib0150 article-title: Screening of bioactive components of the flower publication-title: Int. J. PharTech Res. contributor: fullname: Sornaraj – volume: 456 start-page: 394 year: 1999 end-page: 398 ident: bib0390 article-title: AlphaCaMKII binding to the C-terminal tail of NMDA receptor subunit NR2A and its modulation by autophosphorylation publication-title: FEBS Lett. contributor: fullname: Di Luca – year: 2010 ident: bib0195 article-title: Glutamatergic neurotransmission in the hippocampus publication-title: Hippocampal Microcircuits A Computational Modeler’s Resource Book contributor: fullname: Cutsuridis – volume: 5 start-page: 857 year: 2015 end-page: 862 ident: bib0275 article-title: Evaluation of publication-title: J. Vet. Adv. contributor: fullname: Adawa – year: 2014 ident: bib0210 article-title: Spike-frequency adaptation publication-title: Encycl. Comp. Neurosci. contributor: fullname: Tabak – volume: 40 start-page: 166 year: 2017 ident: bib0200 article-title: NMDA receptor-mediated Ca publication-title: Sleep contributor: fullname: Ping – volume: 11 start-page: 1937 year: 2017 end-page: 1947 ident: bib0255 article-title: Atropine exposure in adolescence predispose to adult memory loss in Wistar rats publication-title: Int. J. Biol. Chem. Sci. contributor: fullname: Olayaki – volume: 9 start-page: 79 year: 1974 end-page: 81 ident: bib0125 article-title: Investigations on publication-title: Bangladesh J. Sci. Ind. Res. contributor: fullname: Kiamuddin – volume: 62 start-page: 63 year: 2012 end-page: 77 ident: bib0325 article-title: Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders publication-title: Neuropharmacology contributor: fullname: Popoli – volume: 4 start-page: 5710 year: 2012 ident: bib0240 article-title: NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD) publication-title: Cold Spring Harb. Perspect. Biol. contributor: fullname: Malenka – volume: 14 start-page: 154 year: 2011 end-page: 161 ident: bib0370 article-title: A comprehensive review of opioid-induced hyperalgesia publication-title: Pain Phys. contributor: fullname: Manchikanti – volume: 44 start-page: 5 year: 2004 end-page: 21 ident: bib0345 article-title: LTP and LTD: an embarassment of riches publication-title: Neuron contributor: fullname: Bear – volume: 7 start-page: 43 year: 2017 end-page: 58 ident: bib0030 article-title: Medical importance of publication-title: IOSR J. Pharm. contributor: fullname: Al-Snafi – volume: 90 start-page: 1522 year: 2007 end-page: 1528 ident: bib0140 article-title: Withanolide compounds from the flower of publication-title: Helv. Chim. Acta contributor: fullname: Kuang – volume: 86 start-page: 1142 year: 2008 end-page: 1152 ident: bib0590 article-title: NR1 and GluR2 expression mediate excitotoxicity in chronic hypobaric hypoxia publication-title: J. Neurosci. Res. contributor: fullname: Ilavazhagan – volume: 37 start-page: 1369 year: 2009 end-page: 1374 ident: bib0235 article-title: Regulation of NMDA receptor Ca publication-title: Biochem. Soc. Trans. contributor: fullname: Zukin – volume: 2 start-page: 602 year: 2015 end-page: 605 ident: bib0025 article-title: A review on phytochemical and pharmacological status of publication-title: Int. J. Multidiscip. Res. Dev. contributor: fullname: Jayshree – volume: 87 start-page: 26 year: 2014 end-page: 34 ident: bib0160 article-title: New anti-inflammatory withanolides from the leaves of publication-title: Steroids contributor: fullname: Kuang – year: 2010 ident: bib0055 article-title: Drug Abuse and Drug Dependence Treatment Situation. Activity Report contributor: fullname: Moses – volume: 4 start-page: 322 year: 2004 end-page: 331 ident: bib0540 article-title: Recovery of hippocampal cell proliferation and BDNF levels, both of which are reduced by repeated restraint stress, is accelerated by chronic venlafaxine publication-title: Pharmacogenomics J. contributor: fullname: Li – volume: 85 start-page: 842 year: 2006 end-page: 849 ident: bib0560 article-title: Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper publication-title: Pharmacol. Biochem. Behav. contributor: fullname: Bjorvatn – volume: 302 start-page: 890 year: 2003 end-page: 893 ident: bib0520 article-title: DNA methylation-related chromatin remodelling in activity-dependent BDNF gene regulation publication-title: Science contributor: fullname: Hu – volume: 58 start-page: 109 year: 2005 end-page: 112 ident: bib0080 article-title: Dietary level and plasma concentration of micronutrients in crossbred dairy cows fed finger millet and rice straw as dry roughage source publication-title: Indian J. Dairy Sci. contributor: fullname: Gowda – volume: 38 start-page: 1067 year: 2010 end-page: 1074 ident: bib0525 article-title: NMDA receptor activation induces differential epigenetic modification of Bdnf promoters in hippocampal neurons publication-title: Amino Acids contributor: fullname: Lipsky – volume: 369 year: 2014 ident: bib0245 article-title: NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci. contributor: fullname: Collingridge – volume: 19 start-page: 150 year: 1996 end-page: 154 ident: bib0215 article-title: Ca publication-title: Trends Neurosci. contributor: fullname: Sah – year: 2018 ident: bib0010 article-title: World Drug Report: Executive Summary Conclusions and Policy Implications contributor: fullname: United Nations Office on Drugs and Crime UNODC – volume: 1003 start-page: 250 year: 2003 end-page: 272 ident: bib0330 article-title: Glutamate and depression: clinical and preclinical studies publication-title: Ann. N. Y. Acad. Sci. contributor: fullname: Skolnick – volume: 11 start-page: 18 year: 2019 ident: bib0120 article-title: SK channel modulates synaptic plasticity by tuning CaMKIIα/β dynamics publication-title: Front. Cell. Neurosci. contributor: fullname: Ogundele – volume: 288 start-page: 24151 year: 2013 end-page: 24159 ident: bib0500 article-title: Involvement of the GluN2A and GluN2B subunits in synaptic and extrasynaptic N-methyl-D-aspartate receptor function and neuronal excitotoxicity publication-title: J. Biol. Chem. contributor: fullname: Wang – volume: 2 start-page: 46 year: 2010 end-page: 48 ident: bib0020 article-title: Phytochemical studies on publication-title: J. Phytol. contributor: fullname: Bhuktar – volume: 34 start-page: 868 year: 1993 end-page: 870 ident: bib0130 article-title: Withanolides of publication-title: Phytocemistry contributor: fullname: Ray – volume: 74 start-page: 59 year: 2013 end-page: 68 ident: bib0350 article-title: The intersections of NMDAR-dependent synaptic plasticity and cell survival publication-title: Neuropharmacology contributor: fullname: Wang – volume: 33 start-page: 383 year: 2002 end-page: 395 ident: bib0510 article-title: A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF publication-title: Neuron contributor: fullname: Greenberg – volume: 199 start-page: 1 year: 1980 end-page: 19 ident: bib0225 article-title: Evidence for two physiologically distinct perforant pathways to the fascia dentata publication-title: Brain Res. contributor: fullname: McNaughton – volume: 13 start-page: 169 year: 2014 end-page: 182 ident: bib0400 article-title: Mechanisms of CaMKII action in long-term potentiation publication-title: Nat. Rev. Neurosci. contributor: fullname: Raghavachari – volume: 3 start-page: 935 year: 2004 ident: bib0175 article-title: Docking and scoring in virtual screening for drug discovery: methods and applications publication-title: Nat. Rev. Drug Discov. contributor: fullname: Bajorath – volume: 6 start-page: 280 year: 2014 end-page: 285 ident: bib0270 article-title: Antioxidant activity and phytochemical analysis of publication-title: Int. J. Drug Dev. Res. contributor: fullname: Sathiavelu – volume: 62 start-page: 405 year: 2010 end-page: 496 ident: bib0285 article-title: Glutamate receptor ion channels: structure, regulation, and function publication-title: Pharmacol. Rev. contributor: fullname: Dingledine – volume: 8 start-page: 165 year: 2013 end-page: 173 ident: bib0290 article-title: Changes in surface expression of N-methyl-D-aspartate receptors in the striatum in a rat model of Parkinson’s disease publication-title: Drug Des. Dev. Ther. contributor: fullname: Liu – year: 2018 ident: bib0005 article-title: Illegal drug use on the rise in Africa publication-title: DW Made for Minds contributor: fullname: Ndinda – volume: 108 start-page: 123 year: 2016 end-page: 135 ident: bib0040 article-title: Structural analysis of bio-oils from subcritical and supercritical hydrothermal liquefaction of Datura stramonium L publication-title: J. Supercrit. Fluids contributor: fullname: Aysu – volume: 38 start-page: 1646 year: 2015 end-page: 1648 ident: bib0165 article-title: Study on chemical constituents in seeds of publication-title: Hong Yao Cai contributor: fullname: Wang – volume: 2 start-page: 1002 year: 2012 end-page: 1008 ident: bib0060 article-title: Pharmacological properties of Datura stramonium L. as a potential medicinal tree: an overview publication-title: Asian Pac. J. Trop. Biomed. contributor: fullname: Soni – volume: 32 start-page: 1504 year: 2007 end-page: 1519 ident: bib0550 article-title: Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus publication-title: Neuropsychopharmacology contributor: fullname: Duman – volume: 103 start-page: 9715 year: 2006 end-page: 9720 ident: bib0295 article-title: Nociceptin/orphanin FQ presynaptically decreases GABAergic transmission and blocks the ethanol-induced increase GABA release in central anygdala publication-title: PNAS contributor: fullname: Siggins – volume: 7 year: 2012 ident: bib0425 article-title: Stress-induced changes of hippocampal NMDA receptors: modulation by duloxetine treatment publication-title: PLoS One contributor: fullname: Riva – volume: a6 start-page: 115 year: 2013 end-page: 119 ident: bib0265 article-title: Evaluation of crude methanolic seed extract of publication-title: Vet. Res. contributor: fullname: Adawa – volume: 9 start-page: 23373 year: 2018 end-page: 233895 ident: bib0445 article-title: Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors publication-title: Oncotarget contributor: fullname: Garzon – volume: 24 start-page: 308 year: 2016 end-page: 311 ident: bib0050 article-title: Datura poisoning, clinical and laboratory findings. Report of five cases publication-title: Rom. J. Leg. Med. contributor: fullname: Fallah – volume: 415 start-page: 307 year: 2012 end-page: 317 ident: bib0435 article-title: Structural basis for activation of calcineurin by calmodulin publication-title: J. Mol. Biol. contributor: fullname: Dunker – volume: 44 start-page: 861 year: 1986 end-page: 870 ident: bib0420 article-title: Regulation of brain type II Ca2+/calmodulin dependent protein kinase by autophosphorylation: a Ca2+-triggered molecular switch publication-title: Cell contributor: fullname: Kennedy – volume: 29 start-page: 1703 year: 2004 end-page: 1709 ident: bib0355 article-title: Repeated restraint stress alters hippocampal glutamate uptake and releases in the rat publication-title: Neurochem. Res. contributor: fullname: Jardim – volume: 558 start-page: 161 year: 2004 end-page: 180 ident: bib0205 article-title: Spike pattering in rat supraoptic neurons in vivo and invitro publication-title: J. Physiol. contributor: fullname: Leng – volume: 102 start-page: 98 year: 2015 end-page: 114 ident: bib0035 article-title: Thermochemical conversion of Datura stramonium L. by supercritical liquefaction and pyrolysis processes publication-title: J. Supercrit. Fluids contributor: fullname: Durak – volume: 29 start-page: 252 year: 1991 end-page: 258 ident: bib0065 article-title: Phytochemical and antimicrobial studies publication-title: Int. J. Pharmacogn. contributor: fullname: Yussuf – volume: 3 start-page: 109 year: 2004 end-page: 113 ident: bib0260 article-title: Neuropsychopharmacological effects of leaves and seeds extracts of publication-title: Biotechnology contributor: fullname: Diatewa – volume: 14 start-page: 269 year: 2009 end-page: 279 ident: bib0320 article-title: Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder publication-title: Mol. Psychiatry contributor: fullname: Bahn – volume: 14 start-page: 402 year: 2004 end-page: 410 ident: bib0360 article-title: Reduced basal CamKII levels in hippocampal CA1 region: a possible cause of stress-induced impairment of LTP in chronically stressed rats publication-title: Hippocampus contributor: fullname: Alkadhi – volume: 31 start-page: 4978 year: 2011 end-page: 4990 ident: bib0470 article-title: A signaling cascade of nuclear calcium-CREB-ATF3 activated by synaptic NMDA receptors defines a gene repression module that protects against extrasynaptic NMDA receptor-induced neuronal cell death and ischemic brain damage publication-title: J. Neurosci. contributor: fullname: Bading – volume: 8 year: 2013 ident: bib0580 article-title: Enriched environment prevents hypobaric hypoxia induced memory impairment and neurodegeneration: role of BDNF/PI3K/GSK3β pathway coupled with CREB activation publication-title: PLoS One contributor: fullname: Ilavazhagan – volume: 212 start-page: 5 year: 2008 end-page: 13 ident: bib0585 article-title: Chronic hypobaric hypoxia-induced apoptosis in the CA1 region of the hippocampus: a possible role of NMDAR mediated p75NTR upregulation publication-title: Exp. Neurol. contributor: fullname: Ilavazhagan – volume: 27 start-page: 442 year: 2016 end-page: 443 ident: bib0090 article-title: Datura: the roadside poison publication-title: Wilderness Environ. Med. contributor: fullname: Atreya – volume: 302 start-page: 885 year: 2003 end-page: 889 ident: bib0515 article-title: Depression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2 publication-title: Science contributor: fullname: Griffith – volume: 100 start-page: 475 year: 2009 end-page: 489 ident: bib0220 article-title: Feedback-induced gain control in stochastic spiking networks publication-title: Biol. Cybern. contributor: fullname: Longtin – volume: 79 start-page: 88 year: 2014 end-page: 97 ident: bib0365 article-title: NMDA receptor dysregulation in chronic state: a possible mechanism underlying depression with BDNF downregulation publication-title: Neurochem. Int. contributor: fullname: Britton – volume: 112 start-page: 164 year: 2017 end-page: 171 ident: bib0380 article-title: Selective alterations of NMDAR function and plasticity in D1 and D2 medium spiny neurons in the nucleus accumbens shell following chronic intermittent ethanol exposure publication-title: Neuropharmacology contributor: fullname: Morrisett – volume: 7 year: 2012 ident: bib0430 article-title: Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII publication-title: PLoS One contributor: fullname: Le Nove – volume: 76 start-page: 210 year: 2018 end-page: 217 ident: bib0180 article-title: Docking techniques in pharmacology: How much promising? publication-title: Comput. Biol. Chem. contributor: fullname: Kumar – volume: 35 start-page: 607 year: 2012 end-page: 618 ident: bib0340 article-title: CaMKII regulation in information processing and storage publication-title: Trends Neurosci. contributor: fullname: Bayer – volume: 30 start-page: 2623 year: 2010 end-page: 2635 ident: bib0460 article-title: Suppression of the intrinsic apoptosis pathway by synaptic activity publication-title: J. Neurosci. contributor: fullname: Hardingham – volume: 60 start-page: 1001 year: 2008 end-page: 1007 ident: bib0565 article-title: Expression of brain-derived neurotrophic factor is not modulated by chronic mild stress in the rat hippocampus and amygdala publication-title: Pharmacol. Rep. contributor: fullname: Martin – volume: 306 start-page: 1884 year: 2011 end-page: 1890 ident: bib0305 article-title: Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk publication-title: JAMA contributor: fullname: Willett – volume: 53 start-page: 148 year: 2008 end-page: 154 ident: bib0485 article-title: NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein kinase A and CREB (cAMP-response element-binding protein) pathway publication-title: Neurochem. Int. contributor: fullname: Merino – volume: 91 start-page: 95 year: 2004 end-page: 98 ident: bib0170 article-title: Evaluation of hypoglycemic and antihyperglycemic effects of publication-title: J. Ethnopharmacol. contributor: fullname: Annapurna – volume: 69 start-page: 106 year: 2011 end-page: 119 ident: bib0495 article-title: SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB publication-title: Neuron contributor: fullname: Kitagawa – volume: vol. 3 year: 2010 ident: bib0410 article-title: Calcium/calmodulin-dependent protein kinase II publication-title: Handbook of Cell Signaling contributor: fullname: Kennedy – volume: 30 start-page: 8214 year: 2010 end-page: 8220 ident: bib0450 article-title: CaMKII “autonomy” is required for initiating but not for maintaining neuronal long-term information storage publication-title: J. Neurosci. contributor: fullname: Bayer – volume: 1 start-page: 138 year: 2011 end-page: 146 ident: bib0555 article-title: Effects of different CMS on behaviors, BDNF/CREB/Bcl-2 expression in rat hippocampus publication-title: Biomed. Aging Pathol. contributor: fullname: Wang – volume: 19 start-page: 4548 year: 2014 end-page: 4559 ident: bib0155 article-title: Five withanolides from the Leaves of Datura metel L. and their inhibitory effects on nitric oxide production publication-title: Molecules contributor: fullname: Kuang – volume: 402 start-page: 25 year: 2006 end-page: 29 ident: bib0570 article-title: Effects of quetiapine on the brain derived neurotrophic factor expression in the hippocampus and neocortex of rats publication-title: Neurosci. Lett. contributor: fullname: Kim – volume: 171 start-page: 32 year: 2018 end-page: 49 ident: bib0310 article-title: Role of glutamatergic system and mesocorticolimbic circuits inn alcohol dependence publication-title: Prog. Neurobiol. contributor: fullname: Sari – volume: 42 start-page: 507 year: 2010 end-page: 512 ident: bib0045 article-title: Datura stramonium intake: a report on three cases publication-title: J. Psychoactive Drugs contributor: fullname: Maione – volume: 7 start-page: 139 year: 2011 end-page: 144 ident: bib0085 article-title: Neurotoxic and medicinal properties of Datura stramonium l. – review publication-title: Assam Univ. J. Sci. Technol. contributor: fullname: Sharma – year: 2009 ident: bib0075 article-title: Basic and Clinical Pharmacology contributor: fullname: Trevor – volume: 48 start-page: 289 year: 2005 end-page: 301 ident: bib0415 article-title: NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII publication-title: Neuron contributor: fullname: Malinow – volume: 31 start-page: 455 year: 2010 end-page: 461 ident: bib0110 article-title: AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading publication-title: J. Comp. Chem. contributor: fullname: Olson – volume: 31 start-page: 1094 year: 2008 end-page: 1097 ident: bib0145 article-title: Chemical constituents from the flower of publication-title: Arch. Pharm. Res. contributor: fullname: Feng – volume: 5 start-page: 282 year: 2015 end-page: 291 ident: bib0280 article-title: administration distorts medial prefrontal cortex histology of Wistar rats publication-title: World J. Neurosci. contributor: fullname: Caxton-Martins – volume: 3 start-page: 277 year: 2009 end-page: 281 ident: bib0070 article-title: Isolation, characterization and antibacterial activity of alkaloid from publication-title: Afr. J. Pharm. Pharmacol. contributor: fullname: Ephraim – volume: 6 start-page: 431 year: 2014 end-page: 437 ident: bib0405 article-title: Autonomous CaMKII mediates both LTP and LTD using a mechanism for differential substrate site selection publication-title: Cell Rep. contributor: fullname: Bayer – volume: 29 start-page: 243 year: 2001 end-page: 254 ident: bib0230 article-title: Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons publication-title: Neuron contributor: fullname: Wang – volume: 11 start-page: 682 year: 2010 end-page: 696 ident: bib0465 article-title: Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders publication-title: Nat. Rev. Neurosci. contributor: fullname: Bading – volume: 30 start-page: 1441 year: 2010 end-page: 1449 ident: bib0490 article-title: Activation of NR2A receptors induces ischemic tolerance through CREB signaling publication-title: J. Cereb. Blood Flow Metab. contributor: fullname: Kitagawa – volume: 30 start-page: 2623 year: 2010 ident: 10.1016/j.toxrep.2021.05.009_bib0460 article-title: Suppression of the intrinsic apoptosis pathway by synaptic activity publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5115-09.2010 contributor: fullname: Leveille – volume: 86 start-page: 1142 issue: 5 year: 2008 ident: 10.1016/j.toxrep.2021.05.009_bib0590 article-title: NR1 and GluR2 expression mediate excitotoxicity in chronic hypobaric hypoxia publication-title: J. Neurosci. Res. doi: 10.1002/jnr.21554 contributor: fullname: Hota – volume: 302 start-page: 885 issue: 5646 year: 2003 ident: 10.1016/j.toxrep.2021.05.009_bib0515 article-title: Depression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2 publication-title: Science doi: 10.1126/science.1086446 contributor: fullname: Chen – volume: 69 start-page: 106 issue: 1 year: 2011 ident: 10.1016/j.toxrep.2021.05.009_bib0495 article-title: SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB publication-title: Neuron doi: 10.1016/j.neuron.2010.12.004 contributor: fullname: Sasaki – volume: 31 start-page: 455 year: 2010 ident: 10.1016/j.toxrep.2021.05.009_bib0110 article-title: AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading publication-title: J. Comp. Chem. doi: 10.1002/jcc.21334 contributor: fullname: Trott – volume: 16 start-page: 2785 year: 2009 ident: 10.1016/j.toxrep.2021.05.009_bib0115 article-title: Autodock4 and AutoDockTools4: automated docking with selective receptor flexiblity publication-title: J. Comp. Chem. doi: 10.1002/jcc.21256 contributor: fullname: Morris – volume: 29 start-page: 252 year: 1991 ident: 10.1016/j.toxrep.2021.05.009_bib0065 article-title: Phytochemical and antimicrobial studies publication-title: Int. J. Pharmacogn. contributor: fullname: Yussuf – volume: 97 start-page: 323 year: 1989 ident: 10.1016/j.toxrep.2021.05.009_bib0185 article-title: Activation of N-methyl-D-aspartate receptors contributes to the EPSP at perforant path synapses in the rat dentate gyrus in vitro publication-title: Neurosci. Lett. doi: 10.1016/0304-3940(89)90618-6 contributor: fullname: Lambert – volume: 29 start-page: 1703 issue: 9 year: 2004 ident: 10.1016/j.toxrep.2021.05.009_bib0355 article-title: Repeated restraint stress alters hippocampal glutamate uptake and releases in the rat publication-title: Neurochem. Res. doi: 10.1023/B:NERE.0000035805.46592.6c contributor: fullname: Fontella – volume: 64 start-page: 119 year: 1990 ident: 10.1016/j.toxrep.2021.05.009_bib0190 article-title: A reevaluation of excitatory amino acid-mediated synaptic transmission in rat dentate gyrus publication-title: J. Neurophysiol. doi: 10.1152/jn.1990.64.1.119 contributor: fullname: Lambert – volume: 38 start-page: 1636 issue: 9 year: 2013 ident: 10.1016/j.toxrep.2021.05.009_bib0385 article-title: αCaMKII autophosphorylation controls the establishment of alcohol drinking behaviour publication-title: Neuropsychopharmacology doi: 10.1038/npp.2013.60 contributor: fullname: Easton – volume: 212 start-page: 5 issue: 1 year: 2008 ident: 10.1016/j.toxrep.2021.05.009_bib0585 article-title: Chronic hypobaric hypoxia-induced apoptosis in the CA1 region of the hippocampus: a possible role of NMDAR mediated p75NTR upregulation publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2008.01.030 contributor: fullname: Hota – volume: 14 start-page: 269 year: 2009 ident: 10.1016/j.toxrep.2021.05.009_bib0320 article-title: Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder publication-title: Mol. Psychiatry doi: 10.1038/sj.mp.4002130 contributor: fullname: Lan – volume: 302 start-page: 890 issue: 5646 year: 2003 ident: 10.1016/j.toxrep.2021.05.009_bib0520 article-title: DNA methylation-related chromatin remodelling in activity-dependent BDNF gene regulation publication-title: Science doi: 10.1126/science.1090842 contributor: fullname: Martinowich – volume: 11 start-page: 682 year: 2010 ident: 10.1016/j.toxrep.2021.05.009_bib0465 article-title: Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn2911 contributor: fullname: Hardingham – volume: 30 start-page: 1441 issue: 8 year: 2010 ident: 10.1016/j.toxrep.2021.05.009_bib0490 article-title: Activation of NR2A receptors induces ischemic tolerance through CREB signaling publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2010.18 contributor: fullname: Terasaki – volume: 31 start-page: 4978 year: 2011 ident: 10.1016/j.toxrep.2021.05.009_bib0470 article-title: A signaling cascade of nuclear calcium-CREB-ATF3 activated by synaptic NMDA receptors defines a gene repression module that protects against extrasynaptic NMDA receptor-induced neuronal cell death and ischemic brain damage publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2672-10.2011 contributor: fullname: Zhang – year: 2017 ident: 10.1016/j.toxrep.2021.05.009_bib0015 contributor: fullname: United Nations Office on Drugs and Crime UNODC – volume: 5 start-page: 282 year: 2015 ident: 10.1016/j.toxrep.2021.05.009_bib0280 article-title: Datura metel administration distorts medial prefrontal cortex histology of Wistar rats publication-title: World J. Neurosci. doi: 10.4236/wjns.2015.54026 contributor: fullname: Etibor – volume: 3 start-page: 2025 issue: 4 year: 2011 ident: 10.1016/j.toxrep.2021.05.009_bib0150 article-title: Screening of bioactive components of the flower Datura metel using the GC-MS technology publication-title: Int. J. PharTech Res. contributor: fullname: Kiruthika – volume: 62 start-page: 405 issue: 3 year: 2010 ident: 10.1016/j.toxrep.2021.05.009_bib0285 article-title: Glutamate receptor ion channels: structure, regulation, and function publication-title: Pharmacol. Rev. doi: 10.1124/pr.109.002451 contributor: fullname: Traynelis – volume: 306 start-page: 1884 issue: 17 year: 2011 ident: 10.1016/j.toxrep.2021.05.009_bib0305 article-title: Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk publication-title: JAMA doi: 10.1001/jama.2011.1590 contributor: fullname: Chen – volume: 74 start-page: 59 year: 2013 ident: 10.1016/j.toxrep.2021.05.009_bib0350 article-title: The intersections of NMDAR-dependent synaptic plasticity and cell survival publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2013.01.012 contributor: fullname: Barlett – volume: 40 start-page: 166 issue: 12 year: 2017 ident: 10.1016/j.toxrep.2021.05.009_bib0200 article-title: NMDA receptor-mediated Ca2+ influx in the absence of Mg2+ block disrupts rest: activity rhythms in drosophila publication-title: Sleep doi: 10.1093/sleep/zsx166 contributor: fullname: Song – volume: 34 start-page: 868 issue: 3 year: 1993 ident: 10.1016/j.toxrep.2021.05.009_bib0130 article-title: Withanolides of Datura fastuosa leaves publication-title: Phytocemistry doi: 10.1016/0031-9422(93)85378-5 contributor: fullname: Manickam – volume: 44 start-page: 861 issue: 60 year: 1986 ident: 10.1016/j.toxrep.2021.05.009_bib0420 article-title: Regulation of brain type II Ca2+/calmodulin dependent protein kinase by autophosphorylation: a Ca2+-triggered molecular switch publication-title: Cell doi: 10.1016/0092-8674(86)90008-5 contributor: fullname: Miller – volume: 24 start-page: 308 issue: 4 year: 2016 ident: 10.1016/j.toxrep.2021.05.009_bib0050 article-title: Datura poisoning, clinical and laboratory findings. Report of five cases publication-title: Rom. J. Leg. Med. doi: 10.4323/rjlm.2016.308 contributor: fullname: Arefi – year: 2009 ident: 10.1016/j.toxrep.2021.05.009_bib0075 contributor: fullname: Katzung – volume: 5 start-page: 857 issue: 4 year: 2015 ident: 10.1016/j.toxrep.2021.05.009_bib0275 article-title: Evaluation of Datura metel l seed extract as a sedative/hypnotic: a preliminary study publication-title: J. Vet. Adv. doi: 10.5455/jva.20150401025957 contributor: fullname: Babalola – volume: vol. 3 year: 2010 ident: 10.1016/j.toxrep.2021.05.009_bib0410 article-title: Calcium/calmodulin-dependent protein kinase II contributor: fullname: Kennedy – volume: 27 start-page: 542 issue: 3 year: 2007 ident: 10.1016/j.toxrep.2021.05.009_bib0530 article-title: Differential roles of NR2A- and NR2B-containing NMDA receptors in activity-dependent brain-derived neurotrophic factor gene regulation and limbic epileptogenesis publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3607-06.2007 contributor: fullname: Chen – volume: 35 start-page: 607 issue: 10 year: 2012 ident: 10.1016/j.toxrep.2021.05.009_bib0340 article-title: CaMKII regulation in information processing and storage publication-title: Trends Neurosci. doi: 10.1016/j.tins.2012.05.003 contributor: fullname: Coultrap – volume: 8 issue: 5 year: 2013 ident: 10.1016/j.toxrep.2021.05.009_bib0580 article-title: Enriched environment prevents hypobaric hypoxia induced memory impairment and neurodegeneration: role of BDNF/PI3K/GSK3β pathway coupled with CREB activation publication-title: PLoS One doi: 10.1371/journal.pone.0062235 contributor: fullname: Jain – volume: 7 issue: 5 year: 2012 ident: 10.1016/j.toxrep.2021.05.009_bib0425 article-title: Stress-induced changes of hippocampal NMDA receptors: modulation by duloxetine treatment publication-title: PLoS One doi: 10.1371/journal.pone.0037916 contributor: fullname: Calabrese – volume: 90 start-page: 1522 issue: 8 year: 2007 ident: 10.1016/j.toxrep.2021.05.009_bib0140 article-title: Withanolide compounds from the flower of Datura metel L publication-title: Helv. Chim. Acta doi: 10.1002/hlca.200790159 contributor: fullname: Yang – volume: 53 start-page: 148 issue: 5 year: 2008 ident: 10.1016/j.toxrep.2021.05.009_bib0485 article-title: NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein kinase A and CREB (cAMP-response element-binding protein) pathway publication-title: Neurochem. Int. doi: 10.1016/j.neuint.2008.07.007 contributor: fullname: Valera – volume: 9 start-page: 79 issue: 1/2 year: 1974 ident: 10.1016/j.toxrep.2021.05.009_bib0125 article-title: Investigations on Datura fastuosa Solanaceae part 5: isolation of fastusine scopolamine and beta sitosterol from the pericarp fruit shell publication-title: Bangladesh J. Sci. Ind. Res. contributor: fullname: Khaleque – volume: 42 start-page: 507 issue: 4 year: 2010 ident: 10.1016/j.toxrep.2021.05.009_bib0045 article-title: Datura stramonium intake: a report on three cases publication-title: J. Psychoactive Drugs doi: 10.1080/02791072.2010.10400713 contributor: fullname: Stella – volume: 19 start-page: 150 year: 1996 ident: 10.1016/j.toxrep.2021.05.009_bib0215 article-title: Ca2+ -activated K+ currents in neurones: types, physiological roles and modulation publication-title: Trends Neurosci. doi: 10.1016/S0166-2236(96)80026-9 contributor: fullname: Sah – volume: 21 start-page: 1501 issue: 5 year: 2001 ident: 10.1016/j.toxrep.2021.05.009_bib0395 article-title: Hippocampal synaptic plasticity involves competition between Ca2+/calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.21-05-01501.2001 contributor: fullname: Gardoni – volume: 415 start-page: 307 issue: 12 year: 2012 ident: 10.1016/j.toxrep.2021.05.009_bib0435 article-title: Structural basis for activation of calcineurin by calmodulin publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2011.11.008 contributor: fullname: Rumi-Masante – volume: 70 start-page: 1127 issue: 7 year: 2007 ident: 10.1016/j.toxrep.2021.05.009_bib0135 article-title: Cytotoxic withanolides from the flowers of Datura metel publication-title: J. Nat. Prod. doi: 10.1021/np070096b contributor: fullname: Pan – volume: 369 issue: 1633 year: 2014 ident: 10.1016/j.toxrep.2021.05.009_bib0245 article-title: NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci. doi: 10.1098/rstb.2013.0131 contributor: fullname: Park – volume: 2 start-page: 46 issue: 12 year: 2010 ident: 10.1016/j.toxrep.2021.05.009_bib0020 article-title: Phytochemical studies on Datura metel Linn. in Marathwada region, Maharashtra publication-title: J. Phytol. contributor: fullname: Jamdhade – volume: 53 start-page: 129 issue: 2 year: 2005 ident: 10.1016/j.toxrep.2021.05.009_bib0535 article-title: Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly publication-title: Neurosci. Res. doi: 10.1016/j.neures.2005.06.008 contributor: fullname: Murakami – volume: 8 start-page: 165 year: 2013 ident: 10.1016/j.toxrep.2021.05.009_bib0290 article-title: Changes in surface expression of N-methyl-D-aspartate receptors in the striatum in a rat model of Parkinson’s disease publication-title: Drug Des. Dev. Ther. contributor: fullname: Gan – volume: 62 start-page: 63 year: 2012 ident: 10.1016/j.toxrep.2021.05.009_bib0325 article-title: Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2011.07.036 contributor: fullname: Sanacora – volume: 6 start-page: 468 issue: 6 year: 2011 ident: 10.1016/j.toxrep.2021.05.009_bib0505 article-title: NMDA receptor signaling: death or survival? publication-title: Front. Biol. doi: 10.1007/s11515-011-1187-6 contributor: fullname: Luo – volume: 9 start-page: 23373 issue: 34 year: 2018 ident: 10.1016/j.toxrep.2021.05.009_bib0445 article-title: Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors publication-title: Oncotarget doi: 10.18632/oncotarget.25169 contributor: fullname: Rodriguez-Munoz – volume: 85 start-page: 842 issue: 4 year: 2006 ident: 10.1016/j.toxrep.2021.05.009_bib0560 article-title: Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/j.pbb.2006.11.021 contributor: fullname: Gronli – volume: a6 start-page: 115 issue: 5–6 year: 2013 ident: 10.1016/j.toxrep.2021.05.009_bib0265 article-title: Evaluation of crude methanolic seed extract of Datura metel L: as a potential oral anaesthetic in dogs publication-title: Vet. Res. contributor: fullname: Babalola – volume: 22 start-page: 617 year: 2011 ident: 10.1016/j.toxrep.2021.05.009_bib0250 article-title: The NMDA receptor complex as a therapeutic target in epilepsy: a review publication-title: Epilepsy Behav. doi: 10.1016/j.yebeh.2011.07.024 contributor: fullname: Ghasemi – volume: 58 start-page: 109 issue: 2 year: 2005 ident: 10.1016/j.toxrep.2021.05.009_bib0080 article-title: Dietary level and plasma concentration of micronutrients in crossbred dairy cows fed finger millet and rice straw as dry roughage source publication-title: Indian J. Dairy Sci. contributor: fullname: Prasad – year: 2018 ident: 10.1016/j.toxrep.2021.05.009_bib0010 doi: 10.18356/d29e3f27-en contributor: fullname: United Nations Office on Drugs and Crime UNODC – volume: 108 start-page: 123 year: 2016 ident: 10.1016/j.toxrep.2021.05.009_bib0040 article-title: Structural analysis of bio-oils from subcritical and supercritical hydrothermal liquefaction of Datura stramonium L publication-title: J. Supercrit. Fluids doi: 10.1016/j.supflu.2015.10.016 contributor: fullname: Durak – volume: 13 start-page: 169 issue: 3 year: 2014 ident: 10.1016/j.toxrep.2021.05.009_bib0400 article-title: Mechanisms of CaMKII action in long-term potentiation publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3192 contributor: fullname: Lisman – volume: 33 start-page: 383 issue: 3 year: 2002 ident: 10.1016/j.toxrep.2021.05.009_bib0510 article-title: A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF publication-title: Neuron doi: 10.1016/S0896-6273(01)00561-X contributor: fullname: Tao – year: 2014 ident: 10.1016/j.toxrep.2021.05.009_bib0210 article-title: Spike-frequency adaptation publication-title: Encycl. Comp. Neurosci. doi: 10.1007/978-1-4614-7320-6_339-1 contributor: fullname: Benda – volume: 199 start-page: 1 year: 1980 ident: 10.1016/j.toxrep.2021.05.009_bib0225 article-title: Evidence for two physiologically distinct perforant pathways to the fascia dentata publication-title: Brain Res. doi: 10.1016/0006-8993(80)90226-7 contributor: fullname: McNaughton – volume: 32 start-page: 1504 issue: 7 year: 2007 ident: 10.1016/j.toxrep.2021.05.009_bib0550 article-title: Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301276 contributor: fullname: Nair – volume: 44 start-page: 5 year: 2004 ident: 10.1016/j.toxrep.2021.05.009_bib0345 article-title: LTP and LTD: an embarassment of riches publication-title: Neuron doi: 10.1016/j.neuron.2004.09.012 contributor: fullname: Malenka – volume: 2 start-page: 602 issue: 4 year: 2015 ident: 10.1016/j.toxrep.2021.05.009_bib0025 article-title: A review on phytochemical and pharmacological status of Datura fastuosa Linn publication-title: Int. J. Multidiscip. Res. Dev. contributor: fullname: Ganesh – volume: 77 start-page: 14 year: 2017 ident: 10.1016/j.toxrep.2021.05.009_bib0300 article-title: Metabotropic and ionotropic glutamate 5receptors as potential targets for the treatment of alcohol use disorder publication-title: Neurosci. Behav. Rev. doi: 10.1016/j.neubiorev.2017.02.024 contributor: fullname: Goodwani – volume: 100 start-page: 475 year: 2009 ident: 10.1016/j.toxrep.2021.05.009_bib0220 article-title: Feedback-induced gain control in stochastic spiking networks publication-title: Biol. Cybern. doi: 10.1007/s00422-009-0298-5 contributor: fullname: Sutherland – volume: 1 start-page: 138 issue: 3 year: 2011 ident: 10.1016/j.toxrep.2021.05.009_bib0555 article-title: Effects of different CMS on behaviors, BDNF/CREB/Bcl-2 expression in rat hippocampus publication-title: Biomed. Aging Pathol. doi: 10.1016/j.biomag.2010.10.006 contributor: fullname: Xiao – volume: 27 start-page: 442 year: 2016 ident: 10.1016/j.toxrep.2021.05.009_bib0090 article-title: Datura: the roadside poison publication-title: Wilderness Environ. Med. doi: 10.1016/j.wem.2016.04.007 contributor: fullname: Kanchan – volume: 76 start-page: 210 year: 2018 ident: 10.1016/j.toxrep.2021.05.009_bib0180 article-title: Docking techniques in pharmacology: How much promising? publication-title: Comput. Biol. Chem. doi: 10.1016/j.compbiolchem.2018.06.005 contributor: fullname: Gupta – volume: 3 start-page: 277 issue: 5 year: 2009 ident: 10.1016/j.toxrep.2021.05.009_bib0070 article-title: Isolation, characterization and antibacterial activity of alkaloid from Datura metel Linn leaves publication-title: Afr. J. Pharm. Pharmacol. contributor: fullname: Donatus – volume: 14 start-page: 154 issue: 2 year: 2011 ident: 10.1016/j.toxrep.2021.05.009_bib0370 article-title: A comprehensive review of opioid-induced hyperalgesia publication-title: Pain Phys. contributor: fullname: Lee – volume: 558 start-page: 161 issue: 1 year: 2004 ident: 10.1016/j.toxrep.2021.05.009_bib0205 article-title: Spike pattering in rat supraoptic neurons in vivo and invitro publication-title: J. Physiol. doi: 10.1113/jphysiol.2004.063982 contributor: fullname: Sabatier – volume: 96 start-page: 1430 year: 2018 ident: 10.1016/j.toxrep.2021.05.009_bib0480 article-title: The differences between GluN2A and GluN2B signaling in the brain publication-title: J. Neurosci. Res. doi: 10.1002/jnr.24251 contributor: fullname: Sun – year: 2010 ident: 10.1016/j.toxrep.2021.05.009_bib0195 article-title: Glutamatergic neurotransmission in the hippocampus contributor: fullname: Tόth – volume: 7 issue: 9 year: 2012 ident: 10.1016/j.toxrep.2021.05.009_bib0430 article-title: Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII publication-title: PLoS One contributor: fullname: Li – volume: 6 start-page: 431 year: 2014 ident: 10.1016/j.toxrep.2021.05.009_bib0405 article-title: Autonomous CaMKII mediates both LTP and LTD using a mechanism for differential substrate site selection publication-title: Cell Rep. doi: 10.1016/j.celrep.2014.01.005 contributor: fullname: Coultrap – volume: 79 start-page: 88 year: 2014 ident: 10.1016/j.toxrep.2021.05.009_bib0365 article-title: NMDA receptor dysregulation in chronic state: a possible mechanism underlying depression with BDNF downregulation publication-title: Neurochem. Int. doi: 10.1016/j.neuint.2014.09.007 contributor: fullname: Vasquez – volume: 36 start-page: 1890 issue: 5 year: 2015 ident: 10.1016/j.toxrep.2021.05.009_bib0335 article-title: D-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2015.02.003 contributor: fullname: Cristino – volume: 402 start-page: 25 issue: 1–2 year: 2006 ident: 10.1016/j.toxrep.2021.05.009_bib0570 article-title: Effects of quetiapine on the brain derived neurotrophic factor expression in the hippocampus and neocortex of rats publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2006.03.028 contributor: fullname: Park – volume: 19 start-page: 4548 year: 2014 ident: 10.1016/j.toxrep.2021.05.009_bib0155 article-title: Five withanolides from the Leaves of Datura metel L. and their inhibitory effects on nitric oxide production publication-title: Molecules doi: 10.3390/molecules19044548 contributor: fullname: Yang – volume: 288 start-page: 24151 issue: 33 year: 2013 ident: 10.1016/j.toxrep.2021.05.009_bib0500 article-title: Involvement of the GluN2A and GluN2B subunits in synaptic and extrasynaptic N-methyl-D-aspartate receptor function and neuronal excitotoxicity publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.482000 contributor: fullname: Zhou – volume: 3 start-page: 935 issue: 11 year: 2004 ident: 10.1016/j.toxrep.2021.05.009_bib0175 article-title: Docking and scoring in virtual screening for drug discovery: methods and applications publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd1549 contributor: fullname: Kitchen – volume: 38 start-page: 1646 issue: 8 year: 2015 ident: 10.1016/j.toxrep.2021.05.009_bib0165 article-title: Study on chemical constituents in seeds of Datura metel from Xinjiang publication-title: Hong Yao Cai contributor: fullname: Han – volume: 456 start-page: 394 issue: 3 year: 1999 ident: 10.1016/j.toxrep.2021.05.009_bib0390 article-title: AlphaCaMKII binding to the C-terminal tail of NMDA receptor subunit NR2A and its modulation by autophosphorylation publication-title: FEBS Lett. doi: 10.1016/S0014-5793(99)00985-0 contributor: fullname: Gardoni – volume: 4 start-page: 5710 issue: 6 year: 2012 ident: 10.1016/j.toxrep.2021.05.009_bib0240 article-title: NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD) publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a005710 contributor: fullname: Lűscher – volume: 2 start-page: 1002 issue: 12 year: 2012 ident: 10.1016/j.toxrep.2021.05.009_bib0060 article-title: Pharmacological properties of Datura stramonium L. as a potential medicinal tree: an overview publication-title: Asian Pac. J. Trop. Biomed. doi: 10.1016/S2221-1691(13)60014-3 contributor: fullname: Soni – volume: 392 start-page: 198 issue: 6672 year: 1998 ident: 10.1016/j.toxrep.2021.05.009_bib0475 article-title: Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons publication-title: Nature doi: 10.1038/32448 contributor: fullname: Deisseroth – year: 2018 ident: 10.1016/j.toxrep.2021.05.009_bib0005 article-title: Illegal drug use on the rise in Africa contributor: fullname: Ndinda – volume: 171 start-page: 32 year: 2018 ident: 10.1016/j.toxrep.2021.05.009_bib0310 article-title: Role of glutamatergic system and mesocorticolimbic circuits inn alcohol dependence publication-title: Prog. Neurobiol. doi: 10.1016/j.pneurobio.2018.10.001 contributor: fullname: Alasmari – volume: 162 start-page: 107783 year: 2020 ident: 10.1016/j.toxrep.2021.05.009_bib0375 article-title: Ketamine reduces remifentanil-induced postoperative hyperalgesia mediated by CaMKII-NMDAR in the primary somatosensory cerebral cortex region in mice publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2019.107783 contributor: fullname: Qi – volume: 14 start-page: 402 issue: 3 year: 2004 ident: 10.1016/j.toxrep.2021.05.009_bib0360 article-title: Reduced basal CamKII levels in hippocampal CA1 region: a possible cause of stress-induced impairment of LTP in chronically stressed rats publication-title: Hippocampus doi: 10.1002/hipo.10193 contributor: fullname: Gerges – volume: 3 start-page: 109 issue: 2 year: 2004 ident: 10.1016/j.toxrep.2021.05.009_bib0260 article-title: Neuropsychopharmacological effects of leaves and seeds extracts of Datura fastuosa publication-title: Biotechnology doi: 10.3923/biotech.2004.109.113 contributor: fullname: Abena – volume: 6 start-page: 280 issue: 4 year: 2014 ident: 10.1016/j.toxrep.2021.05.009_bib0270 article-title: Antioxidant activity and phytochemical analysis of Datura metel publication-title: Int. J. Drug Dev. Res. contributor: fullname: Deepa – volume: 102 start-page: 98 year: 2015 ident: 10.1016/j.toxrep.2021.05.009_bib0035 article-title: Thermochemical conversion of Datura stramonium L. by supercritical liquefaction and pyrolysis processes publication-title: J. Supercrit. Fluids doi: 10.1016/j.supflu.2015.04.008 contributor: fullname: Aysu – volume: 100 start-page: 10512 issue: 18 year: 2003 ident: 10.1016/j.toxrep.2021.05.009_bib0440 article-title: An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signalling publication-title: PNAS doi: 10.1073/pnas.1932759100 contributor: fullname: Bradshaw – volume: 7 start-page: 139 issue: 1 year: 2011 ident: 10.1016/j.toxrep.2021.05.009_bib0085 article-title: Neurotoxic and medicinal properties of Datura stramonium l. – review publication-title: Assam Univ. J. Sci. Technol. contributor: fullname: Devi – volume: 9 start-page: 1 issue: 1 year: 2014 ident: 10.1016/j.toxrep.2021.05.009_bib0100 article-title: Phytochemical evaluation and investigations in to sedative properties of Datura stramonium (Linn) seeds in experimental mice publication-title: IOSR J. Pharm. Biol. Sci. contributor: fullname: Malami – volume: 60 start-page: 1001 issue: 6 year: 2008 ident: 10.1016/j.toxrep.2021.05.009_bib0565 article-title: Expression of brain-derived neurotrophic factor is not modulated by chronic mild stress in the rat hippocampus and amygdala publication-title: Pharmacol. Rep. contributor: fullname: Allaman – volume: 1003 start-page: 250 year: 2003 ident: 10.1016/j.toxrep.2021.05.009_bib0330 article-title: Glutamate and depression: clinical and preclinical studies publication-title: Ann. N. Y. Acad. Sci. doi: 10.1196/annals.1300.016 contributor: fullname: Paul – volume: 46 start-page: 720 year: 2011 ident: 10.1016/j.toxrep.2021.05.009_bib0455 article-title: Excitotoxic neuroprotection and vulnerability with CaMKII inhibition publication-title: Mol. Cell. Neurosci. doi: 10.1016/j.mcn.2011.02.003 contributor: fullname: Ashpole – volume: 11 start-page: 18 year: 2019 ident: 10.1016/j.toxrep.2021.05.009_bib0120 article-title: SK channel modulates synaptic plasticity by tuning CaMKIIα/β dynamics publication-title: Front. Cell. Neurosci. contributor: fullname: Shresta – volume: 11 start-page: 1937 issue: 5 year: 2017 ident: 10.1016/j.toxrep.2021.05.009_bib0255 article-title: Atropine exposure in adolescence predispose to adult memory loss in Wistar rats publication-title: Int. J. Biol. Chem. Sci. doi: 10.4314/ijbcs.v11i5.1 contributor: fullname: Olawepo – volume: 37 start-page: 1369 issue: Pt6 year: 2009 ident: 10.1016/j.toxrep.2021.05.009_bib0235 article-title: Regulation of NMDA receptor Ca2+ signaling and synaptic plasticity publication-title: Biochem. Soc. Trans. doi: 10.1042/BST0371369 contributor: fullname: Lau – volume: 4 start-page: 322 issue: 5 year: 2004 ident: 10.1016/j.toxrep.2021.05.009_bib0540 article-title: Recovery of hippocampal cell proliferation and BDNF levels, both of which are reduced by repeated restraint stress, is accelerated by chronic venlafaxine publication-title: Pharmacogenomics J. doi: 10.1038/sj.tpj.6500265 contributor: fullname: Xu – volume: 31 start-page: 1094 issue: 9 year: 2008 ident: 10.1016/j.toxrep.2021.05.009_bib0145 article-title: Chemical constituents from the flower of Datura metel L publication-title: Arch. Pharm. Res. doi: 10.1007/s12272-001-1274-6 contributor: fullname: Kuang – volume: 30 start-page: 8214 year: 2010 ident: 10.1016/j.toxrep.2021.05.009_bib0450 article-title: CaMKII “autonomy” is required for initiating but not for maintaining neuronal long-term information storage publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1469-10.2010 contributor: fullname: Buard – volume: 39 start-page: 77 year: 2018 ident: 10.1016/j.toxrep.2021.05.009_bib0575 article-title: Kaempferol inhibits extrasynaptic NMDAR mediated downregulation of TRKβ in rat hippocampus during hypoxia publication-title: Neuroscience doi: 10.1016/j.neuroscience.2018.09.018 contributor: fullname: Das – volume: 29 start-page: 243 issue: 1 year: 2001 ident: 10.1016/j.toxrep.2021.05.009_bib0230 article-title: Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons publication-title: Neuron doi: 10.1016/S0896-6273(01)00194-5 contributor: fullname: Lu – volume: 7 start-page: 2885 issue: 39 year: 2013 ident: 10.1016/j.toxrep.2021.05.009_bib0105 article-title: Rediscovering the medicinal properties of Datura sp.: a review publication-title: J. Med. Plants Res. contributor: fullname: Maheshwari – volume: 48 start-page: 289 issue: 2 year: 2005 ident: 10.1016/j.toxrep.2021.05.009_bib0415 article-title: NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII publication-title: Neuron doi: 10.1016/j.neuron.2005.08.034 contributor: fullname: Barria – volume: 38 start-page: 1067 issue: 4 year: 2010 ident: 10.1016/j.toxrep.2021.05.009_bib0525 article-title: NMDA receptor activation induces differential epigenetic modification of Bdnf promoters in hippocampal neurons publication-title: Amino Acids doi: 10.1007/s00726-009-0315-y contributor: fullname: Tian – year: 2010 ident: 10.1016/j.toxrep.2021.05.009_bib0055 contributor: fullname: Moses – volume: 112 start-page: 164 year: 2017 ident: 10.1016/j.toxrep.2021.05.009_bib0380 article-title: Selective alterations of NMDAR function and plasticity in D1 and D2 medium spiny neurons in the nucleus accumbens shell following chronic intermittent ethanol exposure publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2016.03.004 contributor: fullname: Renteria – volume: 87 start-page: 26 year: 2014 ident: 10.1016/j.toxrep.2021.05.009_bib0160 article-title: New anti-inflammatory withanolides from the leaves of Datura metel L publication-title: Steroids doi: 10.1016/j.steroids.2014.05.003 contributor: fullname: Yang – volume: 91 start-page: 95 year: 2004 ident: 10.1016/j.toxrep.2021.05.009_bib0170 article-title: Evaluation of hypoglycemic and antihyperglycemic effects of Datura metel (Linn.) seeds in normal and alloxan-induced diabetic rats publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2003.12.010 contributor: fullname: Murthy – volume: 103 start-page: 9715 year: 2006 ident: 10.1016/j.toxrep.2021.05.009_bib0295 article-title: Nociceptin/orphanin FQ presynaptically decreases GABAergic transmission and blocks the ethanol-induced increase GABA release in central anygdala publication-title: PNAS doi: 10.1073/pnas.0601899103 contributor: fullname: Roberto – volume: 26 start-page: 237 year: 2014 ident: 10.1016/j.toxrep.2021.05.009_bib0095 article-title: Comparative study of phytochemical screening, antioxidant and antimicrobial capacities of fresh and dry leaves crude plant extracts of Datura metel L publication-title: J. King Saud Univ. - Sci. doi: 10.1016/j.jksus.2013.07.002 contributor: fullname: Hilal – volume: 2013 year: 2013 ident: 10.1016/j.toxrep.2021.05.009_bib0545 article-title: Nobiletin ameliorates the deficits in hippocampal BDNF, TrkB, and synapsin I induced by chronic unpredictable mild stress publication-title: Evid. Complement. Alternat. Med. contributor: fullname: Li – volume: 7 start-page: 43 issue: 2 year: 2017 ident: 10.1016/j.toxrep.2021.05.009_bib0030 article-title: Medical importance of Datura fastuosa (syn: Datura metel) and Datura stramonium – a review publication-title: IOSR J. Pharm. contributor: fullname: Al-Snafi – volume: 62 start-page: 1310 year: 2007 ident: 10.1016/j.toxrep.2021.05.009_bib0315 article-title: Increased levels of glutamate in brains from patients with mood disorders publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2007.03.017 contributor: fullname: Hashimoto |
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Snippet | Datumetine binds with NMDAR altering its calcium current. Acute exposure downregulates NMDAR signalling.
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•Datura intoxication induces an... Datumetine binds with NMDAR altering its calcium current. Acute exposure downregulates NMDAR signalling. • Datura intoxication induces an amnesic experience. •... The usage (abuse) of Datura metel is becoming increasingly worrisome among the Nigerian populace especially among the youth considering its side effects such... |
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SubjectTerms | Datumetine Datura Docking Hippocampus NMDAR Recent trends in environmental toxicology and sustainable agriculture |
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Title | Effects of datumetine on hippocampal NMDAR activity |
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