Current and future biomarkers in allergic asthma

Diagnosis early in life, sensitization, asthma endotypes, monitoring of disease and treatment progression are key motivations for the exploration of biomarkers for allergic rhinitis and allergic asthma. The number of genes related to allergic rhinitis and allergic asthma increases steadily; however,...

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Published inAllergy (Copenhagen) Vol. 71; no. 4; pp. 475 - 494
Main Authors Zissler, U. M., Esser‐von Bieren, J., Jakwerth, C. A., Chaker, A. M., Schmidt‐Weber, C. B.
Format Journal Article
LanguageEnglish
Published Denmark Blackwell Publishing Ltd 01.04.2016
Subjects
Airway Remodeling
allergic asthma
allergic rhinitis
Allergies
Animals
Antigens, Surface - metabolism
Asthma
Asthma - diagnosis
Asthma - etiology
Asthma - metabolism
Asthma - prevention & control
Biomarkers
Environmental Exposure - adverse effects
epithelium
Genetic Predisposition to Disease
Humans
Hypersensitivity - etiology
Hypersensitivity - metabolism
Hypersensitivity - prevention & control
Immune System - cytology
Immune System - immunology
Immune System - metabolism
infiltrate
local biomarkers
Microbiota
infiltrate
local biomarkers
epithelium
allergic rhinitis
allergic asthma
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Abstract Diagnosis early in life, sensitization, asthma endotypes, monitoring of disease and treatment progression are key motivations for the exploration of biomarkers for allergic rhinitis and allergic asthma. The number of genes related to allergic rhinitis and allergic asthma increases steadily; however, prognostic genes have not yet entered clinical application. We hypothesize that the combination of multiple genes may generate biomarkers with prognostic potential. The current review attempts to group more than 161 different potential biomarkers involved in respiratory inflammation to pave the way for future classifiers. The potential biomarkers are categorized into either epithelial or infiltrate‐derived or mixed origin, epithelial biomarkers. Furthermore, surface markers were grouped into cell‐type‐specific categories. The current literature provides multiple biomarkers for potential asthma endotypes that are related to T‐cell phenotypes such as Th1, Th2, Th9, Th17, Th22 and Tregs and their lead cytokines. Eosinophilic and neutrophilic asthma endotypes are also classified by epithelium‐derived CCL‐26 and osteopontin, respectively. There are currently about 20 epithelium‐derived biomarkers exclusively derived from epithelium, which are likely to innovate biomarker panels as they are easy to sample. This article systematically reviews and categorizes genes and collects current evidence that may promote these biomarkers to become part of allergic rhinitis or allergic asthma classifiers with high prognostic value.
AbstractList Diagnosis early in life, sensitization, asthma endotypes, monitoring of disease and treatment progression are key motivations for the exploration of biomarkers for allergic rhinitis and allergic asthma. The number of genes related to allergic rhinitis and allergic asthma increases steadily; however, prognostic genes have not yet entered clinical application. We hypothesize that the combination of multiple genes may generate biomarkers with prognostic potential. The current review attempts to group more than 161 different potential biomarkers involved in respiratory inflammation to pave the way for future classifiers. The potential biomarkers are categorized into either epithelial or infiltrate-derived or mixed origin, epithelial biomarkers. Furthermore, surface markers were grouped into cell-type-specific categories. The current literature provides multiple biomarkers for potential asthma endotypes that are related to T-cell phenotypes such as Th1, Th2, Th9, Th17, Th22 and Tregs and their lead cytokines. Eosinophilic and neutrophilic asthma endotypes are also classified by epithelium-derived CCL-26 and osteopontin, respectively. There are currently about 20 epithelium-derived biomarkers exclusively derived from epithelium, which are likely to innovate biomarker panels as they are easy to sample. This article systematically reviews and categorizes genes and collects current evidence that may promote these biomarkers to become part of allergic rhinitis or allergic asthma classifiers with high prognostic value.
Author Zissler, U. M.
Chaker, A. M.
Jakwerth, C. A.
Schmidt‐Weber, C. B.
Esser‐von Bieren, J.
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  surname: Schmidt‐Weber
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  organization: German Research Center for Environmental Health member of the German Center for Lung Research (DZL)
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26706728$$D View this record in MEDLINE/PubMed
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Issue 4
Keywords infiltrate
local biomarkers
epithelium
allergic rhinitis
allergic asthma
Language English
License 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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Snippet Diagnosis early in life, sensitization, asthma endotypes, monitoring of disease and treatment progression are key motivations for the exploration of biomarkers...
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SubjectTerms Airway Remodeling
allergic asthma
allergic rhinitis
Allergies
Animals
Antigens, Surface - metabolism
Asthma
Asthma - diagnosis
Asthma - etiology
Asthma - metabolism
Asthma - prevention & control
Biomarkers
Environmental Exposure - adverse effects
epithelium
Genetic Predisposition to Disease
Humans
Hypersensitivity - etiology
Hypersensitivity - metabolism
Hypersensitivity - prevention & control
Immune System - cytology
Immune System - immunology
Immune System - metabolism
infiltrate
local biomarkers
Microbiota
Title Current and future biomarkers in allergic asthma
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fall.12828
https://www.ncbi.nlm.nih.gov/pubmed/26706728
https://www.proquest.com/docview/1775719382
https://search.proquest.com/docview/1775633348
https://search.proquest.com/docview/1780520336
Volume 71
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