Nicotinic acid and nicotinamide: a review of their use for hyperphosphatemia in dialysis patients

• Published in: Pharmacotherapy Vol. 33; no. 6; p. 683
• Main Authors: Rennick, Amanda, Kalakeche, Rabih, Seel, Lindsey, Shepler, Brian
• Format: Journal Article
• Language: English
• Published: United States 01.06.2013
• Subjects: Animals; Humans; Hyperphosphatemia - drug therapy; Hyperphosphatemia - etiology; Kidney Failure, Chronic - therapy; Niacin - pharmacology; Niacin - therapeutic use; Niacinamide - pharmacology; Niacinamide - therapeutic use; Peritoneal Dialysis; Phosphorus - blood; Renal Dialysis
• ISSN: 1875-9114
• DOI: 10.1002/phar.1258

Phosphate binders have traditionally been used to treat hyperphosphatemia, a common complication in patients with end stage renal disease (ESRD). New evidence suggests that nicotinic acid and its metabolites may effectively decrease phosphorus absorption in the gastrointestinal tract, thereby reduci...