Effects of Methyl and Isopropyl N-methylanthranilates from Choisya ternata Kunth (Rutaceae) on Experimental Anxiety and Depression in Mice

• Published in: Phytotherapy research Vol. 27; no. 9; pp. 1334 - 1338
• Main Authors: Radulović, Niko S., Miltojević, Ana B., Randjelović, Pavle J., Stojanović, Nikola M., Boylan, Fabio
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.09.2013; Wiley Subscription Services, Inc
• Subjects: Animals; Anti-Anxiety Agents - pharmacology; Antidepressive Agents - pharmacology; Anxiety - drug therapy; Behavior, Animal - drug effects; Body Temperature; Choisya ternata Kunth; Depression - drug therapy; Diazepam - pharmacology; diazepam-induced sleep; Hindlimb Suspension; light/dark test; Male; methyl and isopropyl N-methylanthranilates; Mice; Mice, Inbred BALB C; Oils, Volatile - chemistry; ortho-Aminobenzoates - pharmacology; Plant Extracts - pharmacology; Rutaceae - chemistry; Sleep - drug effects; Swimming; tail suspension test; tail suspension test; diazepam-induced sleep; light/dark test; Choisya ternata Kunth; methyl and isopropyl N-methylanthranilates

Choisya ternata Kunth (Rutaceae) is a plant species used in Mexican folk medicine for its antispasmodic and simulative properties. Recently, we identified a new alkaloid, isopropyl N‐methylanthranilate, and a related one, methyl N‐methylanthranilate, from the essential oil of this species and have p...