MSI1 and HDA6 function interdependently to control flowering time via chromatin modifications

• Published in: The Plant journal : for cell and molecular biology Vol. 109; no. 4; pp. 831 - 843
• Main Authors: Xu, Yingchao, Li, Qing, Yuan, Lianyu, Huang, Yisui, Hung, Fu‐Yu, Wu, Keqiang, Yang, Songguang
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.02.2022
• Subjects: Acetylation; Arabidopsis - genetics; Arabidopsis - metabolism; Arabidopsis Proteins - genetics; Arabidopsis Proteins - metabolism; Arabidopsis thaliana; Chromatin; Chromatin - metabolism; Chromatin Immunoprecipitation; Deacetylation; Flowering; FLOWERING LOCUS C; Flowers - genetics; Flowers - metabolism; Gene expression; Gene Expression Regulation, Plant; Gene Silencing; genes; Histone deacetylase; HISTONE DEACETYLASE 6; Histone Deacetylases - genetics; Histone Deacetylases - metabolism; Histone H3; Histones; Histones - metabolism; Immunoprecipitation; Lysine; MADS AFFECTING FLOWERING 4; MADS AFFECTING FLOWERING 5; MADS Domain Proteins - metabolism; Msi1 protein; MULTICOPY SUPRESSOR OF IRA1; Polycomb group proteins; Polycomb Repressive Complex 2 - genetics; Polycomb Repressive Complex 2 - metabolism; Repressor Proteins - metabolism; Arabidopsis thaliana; MULTICOPY SUPRESSOR OF IRA1; MADS AFFECTING FLOWERING 4; MADS AFFECTING FLOWERING 5; flowering; HISTONE DEACETYLASE 6; FLOWERING LOCUS C

SUMMARY MULTICOPY SUPPRESSOR OF IRA1 (MSI1) is a conserved subunit of Polycomb Repressive Complex 2 (PRC2), which mediates gene silencing by histone H3 lysine 27 trimethylation (H3K27Me3). Here, we demonstrated that MSI1 interacts with the RPD3‐like histone deacetylase HDA6 both in vitro and in vivo...