Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea - comparison with other in vivo genotoxicity endpoints - Cammerer, Zoryana; Bhalli, Javed A.; Cao, Xuefei; Coffing, Stephanie L.; Dickinson, Donna; Dobo, Krista L.; Dobrovolsky, Vasily N.; Engel, Maria; Fiedler, Ronald D.; Gunther, William C.; Heflich, Robert H.; Pearce, Mason G.; et al. (Environmental and molecular mutagenesis, 2011)
Keywords: Animals; Biological and medical sciences; Calibration; CD59; CD59 Antigens - genetics; Colon - drug effects; Colon - ultrastructure; comet assay; Comet Assay - methods; Comet Assay - standards; Data Interpretation, Statistical; Diethylnitrosamine - toxicity; Dose-Response Relationship, Drug; Endpoint Determination; Erythrocytes - drug effects; Erythrocytes - ultrastructure; Flow Cytometry; Fundamental and applied biological sciences. Psychology; gene mutation; Genetics of eukaryotes. Biological and molecular evolution; Hprt; Liver - drug effects; Liver - ultrastructure; Male; Medical sciences; Membrane Proteins - genetics; micronucleus assay; Micronucleus Tests - methods; Micronucleus Tests - standards; Mutagenicity Tests - methods; Mutagenicity Tests - standards; Mutagens - toxicity; Mutation; Organ Specificity; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; reticulocytes; Reticulocytes - drug effects; Reticulocytes - ultrastructure; Species Specificity; Spleen - drug effects; Spleen - ultrastructure; Time Factors; Toxicology; Flow cytometry; Rat; Toxicity; Nitrosoureas; Glycosyltransferases; Genotoxicity; Hprt; Hypoxanthine phosphoribosyltransferase; Comet assay; micronucleus assay; Gene; Micronucleus; CD59; rats; Ungulata; Enzyme; Report; Mutagenicity testing; Transferases; gene mutation; Rodentia; reticulocytes; Pig; In vivo; Vertebrata; Mammalia; Reticulocyte; Artiodactyla; Mutation; Pentosyltransferases