Lovastatin inhibits formation of AA amyloid

• Published in: Journal of leukocyte biology Vol. 83; no. 5; pp. 1295 - 1299
• Main Authors: Hilst, J. C. H., Kluve‐Beckerman, B., Bodar, E. J., Meer, J. W. M., Drenth, J. P. H., Simon, A.
• Format: Journal Article
• Language: English
• Published: United States Society for Leukocyte Biology 01.05.2008
• Subjects: amyloidosis; Amyloidosis - pathology; Amyloidosis - prevention & control; Animals; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; hyper IgD syndrome; isoprenoid; Lovastatin - pharmacology; Lovastatin - therapeutic use; Mice; monocyte; Recombinant Proteins - antagonists & inhibitors; SAA; Serum Amyloid A Protein - antagonists & inhibitors; Serum Amyloid A Protein - biosynthesis; Serum Amyloid A Protein - metabolism

Amyloid A (AA) amyloidosis is a severe complication of many chronic inflammatory disorders, including the hereditary periodic fever syndromes. However, in one of these periodic fever syndromes, the hyper IgD and periodic fever syndrome, amyloidosis is rare despite vigorous, recurring inflammation. T...