Omne Vivum Ex Vivo ... Omne? How to Feed an Inanimate Evolvable Chemical System so as to Let it Self-evolve into Increased Complexity and Life-like Behaviour

“What I cannot create, I do not understand.” Richard Feynman’s bon mot seems almost tailored for experimental systems chemists to realise an important step in the chemical sciences: the creation of living synthetic cells from the entirely inanimate. The underlying idea needs to be simple so the syst...

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Published inIsrael journal of chemistry Vol. 55; no. 8; pp. 851 - 864
Main Author Strazewski, Peter
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.08.2015
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
biosynthesis
Cells (biology)
Chemists
Compartments
Emergence
Genetics
Macromolecules
Monomers
off-equilibrium chemistry
self-evolvable chemistry
synthetic biology
systems chemistry
Thermodynamic equilibrium
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Abstract “What I cannot create, I do not understand.” Richard Feynman’s bon mot seems almost tailored for experimental systems chemists to realise an important step in the chemical sciences: the creation of living synthetic cells from the entirely inanimate. The underlying idea needs to be simple so the system can develop naturally. This proposal aims at the realisation, viz. finding sets of experimentally feasible initial conditions, exploring varied compositions and analysing their outcomes, of a fully synthetic chemical micro‐compartmented and evolvable macromolecular system being fed with monomers and small molecular weight, high energy compounds, to keep the system permanently out of thermodynamic equilibrium and let it self‐evolve, thus gaining: 1) import‐export control of macromolecules across the compartment membranes; 2) food‐dependent increase in macromolecular size, i.e., polymer length inside the compartments; 3) sustained production of new macromolecules through the establishment of a (or several) de novo genetic code(s); leading to 4) the emergence of replicating macromolecular populations; and 5) the emergence of self‐evolved synthetic living cells.
AbstractList “What I cannot create, I do not understand.” Richard Feynman’s bon mot seems almost tailored for experimental systems chemists to realise an important step in the chemical sciences: the creation of living synthetic cells from the entirely inanimate. The underlying idea needs to be simple so the system can develop naturally. This proposal aims at the realisation, viz. finding sets of experimentally feasible initial conditions, exploring varied compositions and analysing their outcomes, of a fully synthetic chemical micro‐compartmented and evolvable macromolecular system being fed with monomers and small molecular weight, high energy compounds, to keep the system permanently out of thermodynamic equilibrium and let it self‐evolve, thus gaining: 1) import‐export control of macromolecules across the compartment membranes; 2) food‐dependent increase in macromolecular size, i.e., polymer length inside the compartments; 3) sustained production of new macromolecules through the establishment of a (or several) de novo genetic code(s); leading to 4) the emergence of replicating macromolecular populations; and 5) the emergence of self‐evolved synthetic living cells.
Abstract “What I cannot create, I do not understand.” Richard Feynman’s bon mot seems almost tailored for experimental systems chemists to realise an important step in the chemical sciences: the creation of living synthetic cells from the entirely inanimate. The underlying idea needs to be simple so the system can develop naturally. This proposal aims at the realisation, viz. finding sets of experimentally feasible initial conditions, exploring varied compositions and analysing their outcomes, of a fully synthetic chemical micro‐compartmented and evolvable macromolecular system being fed with monomers and small molecular weight, high energy compounds, to keep the system permanently out of thermodynamic equilibrium and let it self‐evolve, thus gaining: 1) import‐export control of macromolecules across the compartment membranes; 2) food‐dependent increase in macromolecular size, i.e., polymer length inside the compartments; 3) sustained production of new macromolecules through the establishment of a (or several) de novo genetic code(s); leading to 4) the emergence of replicating macromolecular populations; and 5) the emergence of self‐evolved synthetic living cells.
Author Strazewski, Peter
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  organization: Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (Unité Mixte de Recherche 5246), Université Claude Bernard Lyon 1, 43 bvd du 11 Novembre 1918, 69622 Villeurbanne Cedex (France)
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2008; 100
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2004; 205
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2013; 9
2010; 21
2011; 366
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1971; 93
2010; 1
2012; 134
1994; 269
1990
1986; 8
2004; 34
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2014; 14
1979; 1
2007; 2
2013; 110
1996; 69
1971; 1
2010; 5
2012; 23
2010; 7
2014; 12
2003; 42
2012; 20
2001; 53
2006; 202
2011; 1
2007; 282
2013; 342
1997
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2011; 3
2012; 34
2011; 6
2011; 133
2011; 7
2010; 40
2009; 457
1957; 79
2012; 109
2009; 74
2010; 49
2010; 46
2013; 77
2006; 45
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2002; 124
2011; 93
1991; 64
1997; 36
2004; 56
1971; 36
2012; 45
2006; 106
2005; 11
2010; 50
2005; 13
2012; 41
1998; 8
2009; 42
1987; 70
1993; 66
2013; 20
2005; 259
2000; 8
2000; 7
2010; 267
2008; 9
2008; 3
2009; 159
2007; 37
2012; 51
1976; 30
2014; 5
2013; 14
2013; 12
1999; 15
1976; 434
2003; 9
2006; 361
1997; 16
1968; 90
1999; 96
2003; 125
2014; 50
1996; 26
2006; 128
2011; 683
2005; 35
2014; 53
2001; 98
2002; 36
1994; 116
2015; 5
1994; 235
2009; 20
2012
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1978; 17
2001; 409
2004
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1992; 75
2014; 111
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2005; 44
2009; 26
2014; 357
1989; 28
2012; 74
2002; 27
2011; 2011
1997; 73
2011; 108
2003; 425
1981; 134
1981; 257
1980; 2
1986; 69
2011; 50
2005; 206
2010; 132
2009; 9
2015
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2003; 302
2012; 7
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Snippet “What I cannot create, I do not understand.” Richard Feynman’s bon mot seems almost tailored for experimental systems chemists to realise an important step in...
Abstract “What I cannot create, I do not understand.” Richard Feynman’s bon mot seems almost tailored for experimental systems chemists to realise an important...
"What I cannot create, I do not understand." Richard Feynman's bon mot seems almost tailored for experimental systems chemists to realise an important step in...
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SubjectTerms biosynthesis
Cells (biology)
Chemists
Compartments
Emergence
Genetics
Macromolecules
Monomers
off-equilibrium chemistry
self-evolvable chemistry
synthetic biology
systems chemistry
Thermodynamic equilibrium
Title Omne Vivum Ex Vivo ... Omne? How to Feed an Inanimate Evolvable Chemical System so as to Let it Self-evolve into Increased Complexity and Life-like Behaviour
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