Pulmonary resident neutrophils regulate the production of GM‐CSF and alveolar macrophages

• Published in: The FEBS journal Vol. 283; no. 8; pp. 1465 - 1474
• Main Authors: Tian, Feng, Han, Yong, Song, Jian, Lei, Jie, Yan, Xiaolong, Xie, Nianlin, Wang, Jian, Zhao, Jinbo, Liang, Xiaohua, Zhong, Daixing, Zhou, Yongan, Wang, Xiaoping, Li, Xiaofei
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.04.2016
• Subjects: Airborne particulates; alveolar macrophages; Alveoli; Animals; Apoptosis; Blotting, Western; CD18; CD18 antigen; CD18 Antigens - physiology; Cell Differentiation; Cells, Cultured; Circulatory system; Colony-stimulating factor; Control; Correlation; Cytokines - genetics; Cytokines - metabolism; Depletion; Differentiation; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; GM‐CSF; Granulocyte-macrophage colony-stimulating factor; Granulocyte-Macrophage Colony-Stimulating Factor - genetics; Granulocyte-Macrophage Colony-Stimulating Factor - metabolism; Granulopoiesis; IL‐23; Interleukin 23; Leukocytes (neutrophilic); Lung - cytology; Lung - metabolism; Lungs; Macrophages; Macrophages, Alveolar - cytology; Macrophages, Alveolar - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Neutrophils - cytology; Neutrophils - metabolism; Physiology; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Rodents; IL-23; GM-CSF; neutrophils; CD18; alveolar macrophages

Alveolar macrophages exist in the lung airspaces, and their differentiation and function are considerably regulated by the microenvironment. In this study, we examine the important role of resident neutrophil/IL‐23/granulocyte/macrophage colony‐stimulating factor (GM‐CSF) axis in the development and...