Canavanine augments proapoptotic effects of arginine deprivation in cultured human cancer cells

• Published in: Anti-cancer drugs Vol. 22; no. 2; p. 148
• Main Authors: Vynnytska, Bozhena O, Mayevska, Oksana M, Kurlishchuk, Yuliya V, Bobak, Yaroslav P, Stasyk, Oleh V
• Format: Journal Article
• Language: English
• Published: England 01.02.2011
• Subjects: Apoptosis - drug effects; Arginine - analogs & derivatives; Arginine - deficiency; Arginine - metabolism; Canavanine - pharmacokinetics; Canavanine - pharmacology; Cell Line; Cell Line, Tumor; Cell Proliferation - drug effects; Drug Synergism; Drug Therapy, Combination; HEK293 Cells; HeLa Cells; Hep G2 Cells; Humans; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - pathology; Neoplasms - therapy; Protein Binding

Arginine deprivation achieved by means of recombinant arginine-degrading enzymes is currently being developed as a novel anticancer enzymotherapy. In this study, we showed that arginine deprivation in vitro profoundly and selectively sensitized human cancer cells of different organ origin to low dos...