Association between childhood obesity, trace elements, and heavy metals: Recent discoveries and future perspectives

Summary Trace elements and heavy metals play pivotal roles in health status by regulating a myriad of vital biological functions. Abnormal metal homeostasis has been linked to a constellation of pathogenic complications, including oxidative stress, inflammatory processes, dyslipidemia, and impaired...

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Published inObesity reviews Vol. 25; no. 8; pp. e13764 - n/a
Main Authors González‐Domínguez, Álvaro, Jurado‐Sumariva, Lucía, González‐Domínguez, Raúl
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.08.2024
Subjects
Biomarkers
Carbohydrates
Child
childhood obesity
Children
Comorbidity
disease susceptibility
Dyslipidemia
Environmental factors
health status
Heavy metals
Homeostasis
Humans
hyperlipidemia
Inflammation
interindividual variability
metabolism
metals
Metals, Heavy - adverse effects
Obesity
Oxidative Stress
Pathogenesis
Pediatric Obesity
Precision medicine
Trace Elements
Trace elements (nutrients)
metals
trace elements
interindividual variability
childhood obesity
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Summary:Summary Trace elements and heavy metals play pivotal roles in health status by regulating a myriad of vital biological functions. Abnormal metal homeostasis has been linked to a constellation of pathogenic complications, including oxidative stress, inflammatory processes, dyslipidemia, and impaired insulin‐mediated metabolism of carbohydrates, thereby increasing the odds of developing childhood obesity and related comorbidities. Herein, we provide a comprehensive revision of recent literature on the association between childhood obesity, trace elements, and heavy metals. Further, we emphasize on the crucial importance of addressing the influence that interindividual variability factors (e.g., sex, age, genetic determinants, concomitance of comorbidities, and environmental factors) may have in modulating the susceptibility to disease development. Altogether, this review article represents a concise guide to better understand the involvement of metals in childhood obesity pathogenesis and discusses future needs with the aim of establishing robust biomarkers in the context of precision medicine.
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ISSN:1467-7881
1467-789X
1467-789X
DOI:10.1111/obr.13764