Plasminogen activator‐1 overexpression decreases experimental postthrombotic vein wall fibrosis by a non‐vitronectin‐dependent mechanism

• Published in: Journal of thrombosis and haemostasis Vol. 12; no. 8; pp. 1353 - 1363
• Main Authors: Obi, A. T., Diaz, J. A., Ballard‐Lipka, N. L., Roelofs, K. J., Farris, D. M., Lawrence, D. A., Wakefield, T. W., Henke, P. K.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.08.2014
• Subjects: Animals; Enzyme-Linked Immunosorbent Assay; fibrosis; Fibrosis - prevention & control; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; PAI‐1; Plasminogen Activator Inhibitor 1 - metabolism; postthrombotic syndrome; Postthrombotic Syndrome - prevention & control; Real-Time Polymerase Chain Reaction; Veins - pathology; venous thrombosis; vitronectin; Vitronectin - genetics; Vitronectin - metabolism; PAI-1; fibrosis; postthrombotic syndrome; vitronectin; venous thrombosis

Summary Background Factors associated with postthrombotic syndrome are known clinically, but the underlying cellular processes at the vein wall are not well delineated. Prior work suggests that vein wall damage does not correlate with thrombus resolution but rather with plasminogen activator‐1 (PAI‐...