Frequent Monitoring of C-Peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home

• Published in: The journal of clinical endocrinology and metabolism Vol. 103; no. 9; pp. 3350 - 3358
• Main Authors: Willemsen, Ruben H, Burling, Keith, Barker, Peter, Ackland, Fran, Dias, Renuka P, Edge, Julie, Smith, Anne, Todd, John, Lopez, Boryana, Mander, Adrian P, Guy, Catherine, Dunger, David B
• Format: Journal Article
• Language: English
• Published: United States Copyright Oxford University Press 01.09.2018; Oxford University Press; Endocrine Society
• Subjects: Adolescent; Area Under Curve; Beta cells; Blood Glucose - analysis; Blood Glucose Self-Monitoring - statistics & numerical data; C-Peptide - blood; Child; Clinical s; Correlation of Data; Diabetes; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - blood; Diagnosis; Dried Blood Spot Testing - methods; Dried Blood Spot Testing - statistics & numerical data; Fasting; Fasting - blood; Feasibility Studies; Female; Glucose; Humans; Laboratory testing; Male; Peptides; Time Factors

To evaluate an approach to measure β-cell function by frequent testing of C-peptide concentrations in dried blood spots (DBSs). Thirty-two children, aged 7 to 17 years, with a recent diagnosis of type 1 diabetes. Mixed-meal tolerance test (MMTT) within 6 and again at 12 months after diagnosis, with...