Modulation of the endotoxin receptor (CD14) in septic patients

• Published in: The journal of trauma Vol. 32; no. 4; p. 473
• Main Authors: Birkenmaier, C, Hong, Y S, Horn, J K
• Format: Journal Article
• Language: English
• Published: United States 01.04.1992
• Subjects: Antigens, CD - drug effects; Antigens, CD - metabolism; Antigens, Differentiation, Myelomonocytic - drug effects; Antigens, Differentiation, Myelomonocytic - metabolism; Bacteremia - metabolism; CD11 Antigens; Cells, Cultured; Escherichia coli - drug effects; Escherichia coli - metabolism; Flow Cytometry; Gene Expression Regulation, Bacterial; Humans; Injury Severity Score; Lipopolysaccharide Receptors; Lipopolysaccharides - metabolism; Monocytes - metabolism; Multiple Organ Failure - metabolism; Phenotype; Receptors, Immunologic - drug effects; Receptors, Immunologic - metabolism

The monocyte is a pivotal cell in septic patients that responds to endotoxin with release of inflammatory cytokines. Monocytes display on their surface a receptor (CD14) for complexes formed by endotoxin (lipopolysaccharide, LPS) and a plasma LPS-binding protein (LBP). We compared monocytes obtained...