Tract-specific and age-related variations of the spinal cord microstructure: a multi-parametric MRI study using diffusion tensor imaging (DTI) and inhomogeneous magnetization transfer (ihMT)

• Published in: NMR in biomedicine Vol. 29; no. 6; pp. 817 - 832
• Main Authors: Taso, Manuel, Girard, Olivier M., Duhamel, Guillaume, Le Troter, Arnaud, Feiweier, Thorsten, Guye, Maxime, Ranjeva, Jean-Philippe, Callot, Virginie
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.06.2016; Wiley Subscription Services, Inc; Wiley
• Subjects: Adult; aging; Aging - pathology; Bioengineering; Diffusion; diffusion tensor imaging (DTI); Diffusion Tensor Imaging - methods; Female; Humans; Image Interpretation, Computer-Assisted - methods; inhomogeneous magnetization transfer (ihMT); Life Sciences; Male; Microstructure; Middle Aged; multi-parametric MRI; Multimodal Imaging - methods; Neural Pathways - cytology; Neural Pathways - physiology; Reproducibility of Results; Sensitivity and Specificity; Spinal cord; Spinal Cord - cytology; Spinal Cord - physiology; microstructure; aging; diffusion tensor imaging (DTI); spinal cord; multi-parametric MRI; inhomogeneous magnetization transfer (ihMT); crmbm; Spinal Cord; ihMT; Aging

Being able to finely characterize the spinal cord (SC) microstructure and its alterations is a key point when investigating neural damage mechanisms encountered in different central nervous system (CNS) pathologies, such as multiple sclerosis, amyotrophic lateral sclerosis or myelopathy. Based on no...