Effects of Dopamine Antagonists on Changes in Spontaneous EEG and Locomotor Activity in Ketamine-Treated Rats

• Published in: Pharmacology, biochemistry and behavior Vol. 57; no. 1; pp. 361 - 365
• Main Authors: Yamamoto, M, Mizuki, Y, Suetsugi, M, Ozawa, Y, Ooyama, M, Suzuki, M
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.1997; Elsevier Science
• Subjects: Analysis of Variance; Animals; Benzamides - pharmacology; Biological and medical sciences; Cerebral Cortex - drug effects; Delirium; Dopamine antagonists; Dopamine Antagonists - pharmacology; Drug Evaluation, Preclinical; Drug toxicity and drugs side effects treatment; EEG; Electroencephalography - drug effects; Haloperidol; Haloperidol - pharmacology; Hippocampus - drug effects; Ketamine; Ketamine - pharmacology; Locomotor activity; Male; Medical sciences; Miscellaneous (drug allergy, mutagens, teratogens...); Motor Activity - drug effects; Nemonapride; Pharmacology. Drug treatments; Rats; Rats, Wistar; Delirium; Ketamine; Dopamine antagonists; EEG; Haloperidol; Nemonapride; Locomotor activity; Intraperitoneal administration; Rat; Dopamine receptor; Toxicity; Treatment efficiency; Rodentia; Electrophysiology; Butyrophenone derivatives; Electroencephalography; Locomotion; Vertebrata; Chemotherapy; Mammalia; General anesthetic; Animal; Antagonist; Mechanism of action
• DOI: 10.1016/S0091-3057(96)00304-8
• ISSN: 0091-3057

YAMAMOTO M., Y. MIZUKI, M. SUETSUGI, Y. OZAWA, M. OOYAMA AND M. SUZUKI. Effects of dopamine antagonists on changes in spontaneous EEG and locomotor activity in ketamine-treated rats. PHARMACOL BIOCHEM BEHAV 57(1/2), 361–365, 1997.—We investigated the effects of dopamine antagonists on spontaneous cortical and hippocampal electroencephalographic (EEG) changes, and on hyperlocomotion in ketamine-treated rats. Ketamine (20–60 mg/kg IP) synchronized cortical EEG and desynchronized hippocampal EEG in a dose-dependent manner indicating that the drug induced a dissociation between the cortical and hippocampal EEG. These EEG changes were accompanied by an increase in spontaneous locomotor activity, which involved lack of focused direction, stereotypy, irritability and other abnormalities. Dopamine antagonists, such as haloperidol (0.3–1 mg/kg IP) and nemonapride (0.3–1 mg/kg IP), reversed the dissociation between the cortical and hippocampal EEG in ketamine (60 mg/kg IP)-treated rats. Ketamine-induced hyperlocomotion was also decreased by administration of haloperidol (0.3 and 1 mg/kg IP) or nemonapride (0.1–1 mg/kg IP). Thus, it was found that dopamine antagonists reversed the EEG alterations and behavioural changes in ketamine-treated rats.