EBI1-ligand chemokine(ELC)attracts a broad spectrum of lymphocytes: activated T cells strongly up-regulate CCR7 and efficiently migrate toward ELC

• Published in: International immunology Vol. 10; no. 7; pp. 901 - 910
• Main Author: Yoshida, R
• Format: Journal Article
• Language: English
• Published: England Oxford Publishing Limited (England) 01.07.1998
• Subjects: Adult; B cells; Cell Movement - physiology; chemokine; Chemokine CCL19; chemokine receptor; Chemokines, CC - physiology; Chemotactic Factors - biosynthesis; Chemotactic Factors - metabolism; Chemotactic Factors - physiology; chemotaxis; Chemotaxis, Leukocyte - physiology; homing; Humans; In Situ Hybridization; Lymphocyte Activation - physiology; Lymphocytes; Receptors, CCR7; Receptors, Chemokine - biosynthesis; Receptors, Chemokine - metabolism; Receptors, Chemokine - physiology; RNA, Messenger - metabolism; T cells; T-Lymphocytes - immunology; T-Lymphocytes - physiology; Up-Regulation - physiology

EBI1-ligand chemokine (ELC) is a CC chemokine constitutively expressed in various lymphoid tissues and a high-affinity functional ligand for EBI1/CCR7, a seven transmembrane G-protein-coupled receptor originally identified as an Epstein-Barr virus (EBV)-inducible gene. Here we examined chemotactic a...