Positive End-expiratory Pressure Redistributes Regional Blood Flow and Ventilation Differently in Supine and Prone Humans

• Published in: Anesthesiology (Philadelphia) Vol. 113; no. 6; pp. 1361 - 1369
• Main Authors: Petersson, Johan, Ax, Malin, Frey, Joana, Sánchez-Crespo, Alejandro, Lindahl, Sten G. E., Mure, Margareta
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.12.2010
• Subjects: Adult; Anesthesia; Anesthesia, General; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Carbon Dioxide - blood; Female; Hemodynamics - physiology; Humans; Indium Radioisotopes; Lung - diagnostic imaging; Male; Medical sciences; Middle Aged; Monitoring, Physiologic; Oxygen - blood; Positive-Pressure Respiration; Prone Position - physiology; Pulmonary Circulation - physiology; Pulmonary Gas Exchange - physiology; Regional Blood Flow - physiology; Respiratory Mechanics - physiology; Supine Position - physiology; Technetium Compounds; Tomography, Emission-Computed, Single-Photon; Young Adult; Human; Positive end expiratory pressure; Regional blood flow; Anesthesia

Animal studies have demonstrated an interaction between posture and the effect of positive end-expiratory pressure (PEEP) on regional ventilation and lung blood flow. The aim of this study was to explore this interaction in humans. Regional lung blood flow and ventilation were compared between mecha...