Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines

• Published in: Biochemical and biophysical research communications Vol. 341; no. 2; pp. 635 - 640
• Main Authors: Lin, Yu-Ching, You, Liang, Xu, Zhidong, He, Biao, Mikami, Iwao, Thung, Elaine, Chou, Josephine, Kuchenbecker, Kristopher, Kim, Jae, Raz, Dan, Yang, Cheng-Ta, Chen, Jan-Kan, Jablons, David M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.03.2006
• Subjects: Adaptor Proteins, Signal Transducing; Azacitidine - analogs & derivatives; Azacitidine - pharmacology; Blotting, Western; Carcinoma - pathology; Carrier Proteins - metabolism; Cell Line, Tumor; DNA Methylation; DNA, Complementary - metabolism; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Nasopharyngeal carcinoma; Nasopharyngeal Neoplasms - pathology; Promoter hypermethylation; Promoter Regions, Genetic; Repressor Proteins - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Signal Transduction; Transfection; Wnt inhibitory factor-1; Wnt Proteins - metabolism; Wnt signaling; Nasopharyngeal carcinoma; Wnt signaling; Promoter hypermethylation; Transfection; Wnt inhibitory factor-1

Aberrant activation of Wingless-type (Wnt) signaling pathway plays a critical role in oncogenesis of various human cancers. Wnt inhibitory factor-1 (WIF-1) is a secreted antagonist of Wnt signaling and acts through direct binding to Wnt in the extracelllular space. Recently, we reported Wnt signalin...