Glycoclusters on oligonucleotide and PNA scaffolds: synthesis and applications

• Published in: Chemical Society reviews Vol. 42; no. 11; pp. 4557 - 4573
• Main Authors: Spinelli, Nicolas, Defrancq, Eric, Morvan, François
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 01.01.2013
• Subjects: Calixarenes - chemistry; carbohydrate binding; Carbohydrates; Carbohydrates - chemistry; cell adhesion; Cellular; Chemical Sciences; coatings; Conjugates; Conjugation; Cycloaddition Reaction; DNA; DNA - chemistry; DNA - metabolism; endocytosis; lectins; Lectins - chemistry; Lectins - metabolism; moieties; Nucleic acids; Oligonucleotides; Oligonucleotides - chemical synthesis; Oligonucleotides - chemistry; Organic chemistry; Peptide Nucleic Acids - chemistry; Peptide Nucleic Acids - metabolism; Peptides; Scaffolds; signal transduction; synthesis

Conjugation of oligonucleotides (ONs) to a variety of reporter groups has been the subject of intensive research during the last decade. Conjugation is indeed of great interest because it can be used not only to improve the existing ONs properties but also to impart new ones. In this context tremend...