Test-Retest Reproducibility of the Relative Dose Response for Vitamin A Status in Guatemalan Adults: Issues of Diagnostic Specificity

• Published in: The Journal of nutrition Vol. 120; no. 7; pp. 745 - 750
• Main Authors: Morrow, Frank D., Guerrero, Aura-Marina, Russell, Robert M., Dallal, Gerard, Solomons, Noel W.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.07.1990; American Society for Nutritional Sciences
• Subjects: Administration, Oral; Adult; Biological and medical sciences; CARENCE EN VITAMINES; Chromatography, High Pressure Liquid; DEFICIENCIA DE VITAMINAS; DIAGNOSTIC; diagnostic specificity; DIAGNOSTICO; Dose-Response Relationship, Drug; ENSAYO; EXPERIMENTATION EN LABORATOIRE; EXPERIMENTOS EN LABORATORIO; Fasting; Female; FEMME; GUATEMALA; HOMBRES; HOMME; Human physiology applied to population studies and life conditions. Human ecophysiology; Humans; Male; Medical sciences; MUJERES; Nutritional survey. Food supply and nutritional requirement; PLASMA SANGUIN; PLASMA SANGUINEO; Predictive Value of Tests; PROTEINAS; PROTEINE; relative dose response; Reproducibility of Results; RETINOL; TESTAGE; vitamin A; Vitamin A - administration & dosage; Vitamin A - blood; Guatemala; retinol; relative dose response; vitamin A; diagnostic specificity; humans; Human; Central America; Methodology; Vitamin; Dose activity relation; Retinol; Binding protein; Intraindividual comparison; Reproducibility; America; Interindividual comparison; Guatemala; Diagnosis; Measurement method; Nutritional status; Public health

The relative dose response (RDR) test was examined with regard to specificity and reproducibility in subjects with adequate dietary intake and normal liver reserves of vitamin A. Twelve subjects were administered an RDR test four times over 22 d, including one placebo test in which the oral dose of...