Pre-pandemic cross-reactive antibody and cellular responses against SARS-CoV-2 among female sex workers in Dakar, Senegal

• Published in: Frontiers in public health Vol. 13; p. 1522733
• Main Authors: Herrera, Bobby Brooke, Chaplin, Beth, MBoup, Souleymane, Abdullahi, Adam, He, Michelle, Fisher, Sydney M., Akanmu, Sulaimon, Chang, Charlotte A., Hamel, Donald J., Gupta, Ravindra K., Kanki, Phyllis J.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2025
• Subjects: Adult; Antibodies, Viral - blood; Antibodies, Viral - immunology; antibody; cellular responses; COVID-19 - epidemiology; COVID-19 - immunology; Cross Reactions - immunology; cross-reactivity; Female; Humans; Immunity, Cellular; Middle Aged; Public Health; SARS-CoV-2; SARS-CoV-2 - immunology; Senegal; Senegal - epidemiology; Seroepidemiologic Studies; Sex Workers - statistics & numerical data; Young Adult; Senegal; SARS-CoV-2; cellular responses; cross-reactivity; antibody; Senegal

The COVID-19 pandemic had a severe impact globally, yet African populations exhibited unexpectedly lower rates of severe disease and mortality. We investigated the potential role of pre-existing immunity in shaping the epidemiology of COVID-19 in Africa. Plasma collected from Senegalese female sex w...