Post-translational modifications of beta-amyloid modulate its effect on cell mechanical properties and influence cytoskeletal signaling cascades

• Published in: Frontiers in molecular neuroscience Vol. 17; p. 1501874
• Main Authors: Varshavskaya, Kseniya B., Barykin, Evgeny P., Timoshenko, Roman V., Kolmogorov, Vasilii S., Erofeev, Alexander S., Gorelkin, Petr V., Mitkevich, Vladimir A., Makarov, Alexander A.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.11.2024
• Subjects: actin cytoskeleton; Alzheimer’s disease; beta-amyloid; Molecular Neuroscience; post-translational modifications; ROS; scanning ion-conductance microscopy; actin cytoskeleton; beta-amyloid; cofilin; Alzheimer’s disease; ROS; protein kinases; scanning ion-conductance microscopy; post-translational modifications

Post-translational modifications of beta-amyloid (Aβ) play an important role in the pathogenesis of Alzheimer’s disease (AD). Aβ modifications such as Ser8 phosphorylation (pS8-Aβ 42 ) and Asp7 isomerization (iso-Aβ 42 ) can significantly alter the properties of Aβ and have been detected in vivo . O...