Induction of subject-ventilator asynchrony by variation of respiratory parameters in a lung injury model in pigs

• Published in: Respiratory research Vol. 25; no. 1; pp. 358 - 14
• Main Authors: Ran, Xi, Scharffenberg, Martin, Wittenstein, Jakob, Leidermann, Mark, Güldner, Andreas, Koch, Thea, Gama de Abreu, Marcelo, Huhle, Robert
• Format: Journal Article
• Language: English
• Published: England BioMed Central 03.10.2024; BMC
• Subjects: Animals; Auto-triggering; Disease Models, Animal; Double-triggering; Female; Ineffective efforts; Large animal model; Lung Injury - therapy; Patient-Ventilator Asynchrony; Respiration, Artificial - adverse effects; Subject-ventilator asynchrony; Swine; Ineffective efforts; Auto-triggering; Large animal model; Subject-ventilator asynchrony; Double-triggering

Subject-ventilator asynchrony (SVA) was shown to be associated with negative clinical outcomes. To elucidate pathophysiology pathways and effects of SVA on lung tissue histology a reproducible animal model of artificially induced asynchrony was developed and evaluated. Alterations in ventilator para...