Human restricted CHRFAM7A gene increases brain efficiency
, a uniquely human fusion gene, has been associated with neuropsychiatric disorders including Alzheimer's disease, schizophrenia, anxiety, and attention deficit disorder. Understanding the physiological function of in the human brain is the first step to uncovering its role in disease. CHRFAM7A...
Saved in:
Published in | Frontiers in neuroscience Vol. 18; p. 1359028 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
22.04.2024
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | , a uniquely human fusion gene, has been associated with neuropsychiatric disorders including Alzheimer's disease, schizophrenia, anxiety, and attention deficit disorder. Understanding the physiological function of
in the human brain is the first step to uncovering its role in disease. CHRFAM7A was identified as a potent modulator of intracellular calcium and an upstream regulator of Rac1 leading to actin cytoskeleton reorganization and a switch from filopodia to lamellipodia implicating a more efficient neuronal structure. We performed a neurocognitive-MRI correlation exploratory study on 46 normal human subjects to explore the effect of
on human brain.
Dual locus specific genotyping of
was performed on genomic DNA to determine copy number (TaqMan assay) and orientation (capillary sequencing) of the
alleles. As only the direct allele is expressed at the protein level and affects α7 nAChR function, direct allele carriers and non-carriers are compared for neuropsychological and MRI measures. Subjects underwent neuropsychological testing to measure motor (Timed 25-foot walk test, 9-hole peg test), cognitive processing speed (Symbol Digit Modalities Test), Learning and memory (California Verbal Learning Test immediate and delayed recall, Brief Visuospatial Memory Test-Revised immediate and delayed recall) and Beck Depression Inventory-Fast Screen, Fatigue Severity Scale. All subjects underwent MRI scanning on the same 3 T GE scanner using the same protocol. Global and tissue-specific volumes were determined using validated cross-sectional algorithms including FSL's Structural Image Evaluation, using Normalization, of Atrophy (SIENAX) and FSL's Integrated Registration and Segmentation Tool (FIRST) on lesion-inpainted images. The cognitive tests were age and years of education-adjusted using analysis of covariance (ANCOVA). Age-adjusted analysis of covariance (ANCOVA) was performed on the MRI data.
direct allele carrier and non-carrier groups included 33 and 13 individuals, respectively. Demographic variables (age and years of education) were comparable.
direct allele carriers demonstrated an upward shift in cognitive performance including cognitive processing speed, learning and memory, reaching statistical significance in visual immediate recall (FDR corrected
= 0.018). The shift in cognitive performance was associated with smaller whole brain volume (uncorrected
= 0.046) and lower connectivity by resting state functional MRI in the visual network (FDR corrected
= 0.027) accentuating the cognitive findings.
These data suggest that direct allele carriers harbor a more efficient brain consistent with the cellular biology of actin cytoskeleton and synaptic gain of function. Further larger human studies of cognitive measures correlated with MRI and functional imaging are needed to decipher the impact of
on brain function. |
---|---|
AbstractList | , a uniquely human fusion gene, has been associated with neuropsychiatric disorders including Alzheimer's disease, schizophrenia, anxiety, and attention deficit disorder. Understanding the physiological function of
in the human brain is the first step to uncovering its role in disease. CHRFAM7A was identified as a potent modulator of intracellular calcium and an upstream regulator of Rac1 leading to actin cytoskeleton reorganization and a switch from filopodia to lamellipodia implicating a more efficient neuronal structure. We performed a neurocognitive-MRI correlation exploratory study on 46 normal human subjects to explore the effect of
on human brain.
Dual locus specific genotyping of
was performed on genomic DNA to determine copy number (TaqMan assay) and orientation (capillary sequencing) of the
alleles. As only the direct allele is expressed at the protein level and affects α7 nAChR function, direct allele carriers and non-carriers are compared for neuropsychological and MRI measures. Subjects underwent neuropsychological testing to measure motor (Timed 25-foot walk test, 9-hole peg test), cognitive processing speed (Symbol Digit Modalities Test), Learning and memory (California Verbal Learning Test immediate and delayed recall, Brief Visuospatial Memory Test-Revised immediate and delayed recall) and Beck Depression Inventory-Fast Screen, Fatigue Severity Scale. All subjects underwent MRI scanning on the same 3 T GE scanner using the same protocol. Global and tissue-specific volumes were determined using validated cross-sectional algorithms including FSL's Structural Image Evaluation, using Normalization, of Atrophy (SIENAX) and FSL's Integrated Registration and Segmentation Tool (FIRST) on lesion-inpainted images. The cognitive tests were age and years of education-adjusted using analysis of covariance (ANCOVA). Age-adjusted analysis of covariance (ANCOVA) was performed on the MRI data.
direct allele carrier and non-carrier groups included 33 and 13 individuals, respectively. Demographic variables (age and years of education) were comparable.
direct allele carriers demonstrated an upward shift in cognitive performance including cognitive processing speed, learning and memory, reaching statistical significance in visual immediate recall (FDR corrected
= 0.018). The shift in cognitive performance was associated with smaller whole brain volume (uncorrected
= 0.046) and lower connectivity by resting state functional MRI in the visual network (FDR corrected
= 0.027) accentuating the cognitive findings.
These data suggest that direct allele carriers harbor a more efficient brain consistent with the cellular biology of actin cytoskeleton and synaptic gain of function. Further larger human studies of cognitive measures correlated with MRI and functional imaging are needed to decipher the impact of
on brain function. IntroductionCHRFAM7A, a uniquely human fusion gene, has been associated with neuropsychiatric disorders including Alzheimer’s disease, schizophrenia, anxiety, and attention deficit disorder. Understanding the physiological function of CHRFAM7A in the human brain is the first step to uncovering its role in disease. CHRFAM7A was identified as a potent modulator of intracellular calcium and an upstream regulator of Rac1 leading to actin cytoskeleton reorganization and a switch from filopodia to lamellipodia implicating a more efficient neuronal structure. We performed a neurocognitive-MRI correlation exploratory study on 46 normal human subjects to explore the effect of CHRFAM7A on human brain.MethodsDual locus specific genotyping of CHRFAM7A was performed on genomic DNA to determine copy number (TaqMan assay) and orientation (capillary sequencing) of the CHRFAM7A alleles. As only the direct allele is expressed at the protein level and affects α7 nAChR function, direct allele carriers and non-carriers are compared for neuropsychological and MRI measures. Subjects underwent neuropsychological testing to measure motor (Timed 25-foot walk test, 9-hole peg test), cognitive processing speed (Symbol Digit Modalities Test), Learning and memory (California Verbal Learning Test immediate and delayed recall, Brief Visuospatial Memory Test—Revised immediate and delayed recall) and Beck Depression Inventory—Fast Screen, Fatigue Severity Scale. All subjects underwent MRI scanning on the same 3 T GE scanner using the same protocol. Global and tissue-specific volumes were determined using validated cross-sectional algorithms including FSL’s Structural Image Evaluation, using Normalization, of Atrophy (SIENAX) and FSL’s Integrated Registration and Segmentation Tool (FIRST) on lesion-inpainted images. The cognitive tests were age and years of education-adjusted using analysis of covariance (ANCOVA). Age-adjusted analysis of covariance (ANCOVA) was performed on the MRI data.ResultsCHRFAM7A direct allele carrier and non-carrier groups included 33 and 13 individuals, respectively. Demographic variables (age and years of education) were comparable. CHRFAM7A direct allele carriers demonstrated an upward shift in cognitive performance including cognitive processing speed, learning and memory, reaching statistical significance in visual immediate recall (FDR corrected p = 0.018). The shift in cognitive performance was associated with smaller whole brain volume (uncorrected p = 0.046) and lower connectivity by resting state functional MRI in the visual network (FDR corrected p = 0.027) accentuating the cognitive findings.ConclusionThese data suggest that direct allele carriers harbor a more efficient brain consistent with the cellular biology of actin cytoskeleton and synaptic gain of function. Further larger human studies of cognitive measures correlated with MRI and functional imaging are needed to decipher the impact of CHRFAM7A on brain function. Introduction CHRFAM7A , a uniquely human fusion gene, has been associated with neuropsychiatric disorders including Alzheimer’s disease, schizophrenia, anxiety, and attention deficit disorder. Understanding the physiological function of CHRFAM7A in the human brain is the first step to uncovering its role in disease. CHRFAM7A was identified as a potent modulator of intracellular calcium and an upstream regulator of Rac1 leading to actin cytoskeleton reorganization and a switch from filopodia to lamellipodia implicating a more efficient neuronal structure. We performed a neurocognitive-MRI correlation exploratory study on 46 normal human subjects to explore the effect of CHRFAM7A on human brain. Methods Dual locus specific genotyping of CHRFAM7A was performed on genomic DNA to determine copy number (TaqMan assay) and orientation (capillary sequencing) of the CHRFAM7A alleles. As only the direct allele is expressed at the protein level and affects α7 nAChR function, direct allele carriers and non-carriers are compared for neuropsychological and MRI measures. Subjects underwent neuropsychological testing to measure motor (Timed 25-foot walk test, 9-hole peg test), cognitive processing speed (Symbol Digit Modalities Test), Learning and memory (California Verbal Learning Test immediate and delayed recall, Brief Visuospatial Memory Test—Revised immediate and delayed recall) and Beck Depression Inventory—Fast Screen, Fatigue Severity Scale. All subjects underwent MRI scanning on the same 3 T GE scanner using the same protocol. Global and tissue-specific volumes were determined using validated cross-sectional algorithms including FSL’s Structural Image Evaluation, using Normalization, of Atrophy (SIENAX) and FSL’s Integrated Registration and Segmentation Tool (FIRST) on lesion-inpainted images. The cognitive tests were age and years of education-adjusted using analysis of covariance (ANCOVA). Age-adjusted analysis of covariance (ANCOVA) was performed on the MRI data. Results CHRFAM7A direct allele carrier and non-carrier groups included 33 and 13 individuals, respectively. Demographic variables (age and years of education) were comparable. CHRFAM7A direct allele carriers demonstrated an upward shift in cognitive performance including cognitive processing speed, learning and memory, reaching statistical significance in visual immediate recall (FDR corrected p = 0.018). The shift in cognitive performance was associated with smaller whole brain volume (uncorrected p = 0.046) and lower connectivity by resting state functional MRI in the visual network (FDR corrected p = 0.027) accentuating the cognitive findings. Conclusion These data suggest that direct allele carriers harbor a more efficient brain consistent with the cellular biology of actin cytoskeleton and synaptic gain of function. Further larger human studies of cognitive measures correlated with MRI and functional imaging are needed to decipher the impact of CHRFAM7A on brain function. |
Author | Szigeti, Kinga Zivadinov, Robert Dwyer, Michael G Jakimovski, Dejan Bartnik, Alexander Regno, Megan Del Dorn, Ryu P Benedict, Ralph H B Bergsland, Niels Ramanathan, Murali |
AuthorAffiliation | 4 Center for Biomedical Imaging at the Clinical Translational Science Institute, University at Buffalo, State University of New York , Buffalo, NY , United States 2 Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York , Buffalo, NY , United States 1 Department of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York , Buffalo, NY , United States 3 Department of Pharmaceutical Sciences, University at Buffalo, State University of New York , Buffalo, NY , United States |
AuthorAffiliation_xml | – name: 3 Department of Pharmaceutical Sciences, University at Buffalo, State University of New York , Buffalo, NY , United States – name: 4 Center for Biomedical Imaging at the Clinical Translational Science Institute, University at Buffalo, State University of New York , Buffalo, NY , United States – name: 1 Department of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York , Buffalo, NY , United States – name: 2 Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York , Buffalo, NY , United States |
Author_xml | – sequence: 1 givenname: Dejan surname: Jakimovski fullname: Jakimovski, Dejan organization: Department of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States – sequence: 2 givenname: Ryu P surname: Dorn fullname: Dorn, Ryu P organization: Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States – sequence: 3 givenname: Megan Del surname: Regno fullname: Regno, Megan Del organization: Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States – sequence: 4 givenname: Alexander surname: Bartnik fullname: Bartnik, Alexander organization: Department of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States – sequence: 5 givenname: Niels surname: Bergsland fullname: Bergsland, Niels organization: Department of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States – sequence: 6 givenname: Murali surname: Ramanathan fullname: Ramanathan, Murali organization: Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States – sequence: 7 givenname: Michael G surname: Dwyer fullname: Dwyer, Michael G organization: Center for Biomedical Imaging at the Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, United States – sequence: 8 givenname: Ralph H B surname: Benedict fullname: Benedict, Ralph H B organization: Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States – sequence: 9 givenname: Robert surname: Zivadinov fullname: Zivadinov, Robert organization: Center for Biomedical Imaging at the Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, United States – sequence: 10 givenname: Kinga surname: Szigeti fullname: Szigeti, Kinga organization: Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38711941$$D View this record in MEDLINE/PubMed |
BookMark | eNpVkUtPGzEQgK0KVB7tH-gB7ZFL0rHH3tgnFEWlQaJCQhy4WV7vODXaeMHeVOLfd0NCBCdb8_hmNN8ZO0p9IsZ-cJgiavMzpJjKVICQU47KgNBf2CmvazGRCh-PDn-pT9hZKU8AtdBSfGUnqGecG8lPmVlu1i5VmcqQox-orRbL--v5n9m8WlGiKiafyRUqVZNdTBWFEH2k5F-_sePgukLf9-85e7j-9bBYTm7vft8s5rcTLwUMk9Y0Arx0oSYyBscdWq4bwjHgQZEDzQEwtLNaK0e6pUajQHDQUC2I8Jzd7LBt757sc45rl19t76J9C_R5ZV0eou_ISoNEjhDI11JzrdsmmNA4LxRoVfORdbVjPW-aNbWe0pBd9wn6OZPiX7vq_1nOYQZKwUi43BNy_7IZj2bXsXjqOpeo3xSLoLZ3RcCxVOxKfe5LyRQOczjYrT_75s9u_dm9v7Hp4uOGh5Z3YfgfxFaZYA |
Cites_doi | 10.1016/S1474-4422(12)70191-6 10.1016/j.neuropsychologia.2009.03.004 10.3389/fninf.2014.00014 10.1126/science.abb2401 10.1007/s11065-014-9249-6 10.1016/j.dadm.2017.10.004 10.1074/jbc.M110.180067 10.1177/1352458518819608 10.1080/13554791003730600 10.1016/j.phrs.2023.106783 10.1167/iovs.62.7.20 10.3389/fnagi.2022.854368 10.1002/hbm.21334 10.3390/cells10071795 10.1073/pnas.0905267106 10.1074/jbc.M114.582858 10.1016/j.neuroimage.2013.05.039 10.2174/1570159X15666170912110450 10.1016/j.ebiom.2020.102892 10.1016/j.ebiom.2023.104725 10.1103/PhysRevLett.87.198701 10.1016/j.neuropharm.2011.10.024 10.1111/ejn.15913 10.1016/j.jneuroim.2010.09.008 10.1016/S0165-3806(98)00046-7 10.1038/s41586-022-04554-y 10.1093/cercor/bhac486 10.1212/WNL.96.15_supplement.4379 10.1212/WNL.0000000000000867 10.3390/membranes11090664 10.1002/hbm.24768 10.1016/j.neurobiolaging.2009.02.003 10.1016/j.neuroimage.2009.10.003 10.1177/1352458511431076 10.1016/j.neuroimage.2006.01.021 10.1016/j.neuropharm.2015.02.006 10.3390/ijms21249668 10.1038/s41398-019-0375-z 10.1093/gerona/glab180 10.1212/WNL.0000000000005303 10.18632/aging.102640 10.1001/jamanetworkopen.2021.0169 |
ContentType | Journal Article |
Copyright | Copyright © 2024 Jakimovski, Dorn, Regno, Bartnik, Bergsland, Ramanathan, Dwyer, Benedict, Zivadinov and Szigeti. Copyright © 2024 Jakimovski, Dorn, Regno, Bartnik, Bergsland, Ramanathan, Dwyer, Benedict, Zivadinov and Szigeti. 2024 Jakimovski, Dorn, Regno, Bartnik, Bergsland, Ramanathan, Dwyer, Benedict, Zivadinov and Szigeti |
Copyright_xml | – notice: Copyright © 2024 Jakimovski, Dorn, Regno, Bartnik, Bergsland, Ramanathan, Dwyer, Benedict, Zivadinov and Szigeti. – notice: Copyright © 2024 Jakimovski, Dorn, Regno, Bartnik, Bergsland, Ramanathan, Dwyer, Benedict, Zivadinov and Szigeti. 2024 Jakimovski, Dorn, Regno, Bartnik, Bergsland, Ramanathan, Dwyer, Benedict, Zivadinov and Szigeti |
DBID | NPM AAYXX CITATION 7X8 5PM DOA |
DOI | 10.3389/fnins.2024.1359028 |
DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | PubMed MEDLINE - Academic CrossRef |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology |
EISSN | 1662-453X |
EndPage | 1359028 |
ExternalDocumentID | oai_doaj_org_article_493eeae30ec648188dbf9fbac2508561 10_3389_fnins_2024_1359028 38711941 |
Genre | Journal Article |
GroupedDBID | --- 29H 2WC 53G 5GY 5VS 88I 8FE 8FH 9T4 AAFWJ ABUWG ACGFO ACGFS ACXDI ADRAZ AEGXH AENEX AFKRA AFPKN AIAGR ALMA_UNASSIGNED_HOLDINGS AZQEC BBNVY BENPR BHPHI BPHCQ C1A CCPQU CS3 DIK DU5 DWQXO E3Z EBS EJD EMOBN F5P FRP GNUQQ GROUPED_DOAJ GX1 HCIFZ HYE IAO IEA IHR ISR KQ8 LK8 M2P M48 M7P M~E NPM O5R O5S OK1 P2P PGMZT PIMPY PQQKQ PROAC RNS RPM W2D AAYXX CITATION 7X8 ITC 5PM |
ID | FETCH-LOGICAL-c420t-d9b20c4af6ee993006d18be3af6c05ea081003fd7685ae8deb83230a0be62ee3 |
IEDL.DBID | RPM |
ISSN | 1662-4548 1662-453X |
IngestDate | Tue Oct 22 15:12:25 EDT 2024 Tue Sep 17 21:29:30 EDT 2024 Sat Aug 17 05:14:06 EDT 2024 Mon Sep 16 17:15:58 EDT 2024 Wed Oct 23 09:58:25 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | efficiency neuropsychological assessment CHRFAM7A structural MRI human brain diversity |
Language | English |
License | Copyright © 2024 Jakimovski, Dorn, Regno, Bartnik, Bergsland, Ramanathan, Dwyer, Benedict, Zivadinov and Szigeti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c420t-d9b20c4af6ee993006d18be3af6c05ea081003fd7685ae8deb83230a0be62ee3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Jessica Rosati, Fondazione IRCCS Casa Sollievo della Sofferenza, Italy Reviewed by: Korey Wylie, University of Colorado Anschutz Medical Campus, United States Tapan Nayak, Indian Institute of Technology Delhi, India |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11070550/ |
PMID | 38711941 |
PQID | 3051941303 |
PQPubID | 23479 |
PageCount | 1 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_493eeae30ec648188dbf9fbac2508561 pubmedcentral_primary_oai_pubmedcentral_nih_gov_11070550 proquest_miscellaneous_3051941303 crossref_primary_10_3389_fnins_2024_1359028 pubmed_primary_38711941 |
PublicationCentury | 2000 |
PublicationDate | 2024-04-22 |
PublicationDateYYYYMMDD | 2024-04-22 |
PublicationDate_xml | – month: 04 year: 2024 text: 2024-04-22 day: 22 |
PublicationDecade | 2020 |
PublicationPlace | Switzerland |
PublicationPlace_xml | – name: Switzerland |
PublicationTitle | Frontiers in neuroscience |
PublicationTitleAlternate | Front Neurosci |
PublicationYear | 2024 |
Publisher | Frontiers Media S.A |
Publisher_xml | – name: Frontiers Media S.A |
References | Benfante (ref4) 2011; 230 Kolli (ref21) 2021; 76 Hedman (ref15) 2012; 33 Zoli (ref42) 2018; 16 Latora (ref24) 2001; 87 Wang (ref40) 2014; 289 Dennis (ref12) 2014; 24 de Lucas-Cerrillo (ref11) 2011; 286 Ihnatovych (ref19) 2019; 9 Salimi (ref31) 2018; 10 Brown (ref10) 2014; 83 Ihnatovych (ref18) 2020; 21 Szigeti (ref38) 2023; 95 Stern (ref35) 2009; 47 Borroni (ref9) 2021; 11 Berente (ref5) 2022 Prickaerts (ref29) 2012; 62 Wang (ref39) 2020; 12 Arenaza-Urquijo (ref2) 2018; 90 Sinkus (ref32) 2015; 96 Szigeti (ref37) 2020; 59 Stern (ref36) 2012; 11 Leonard (ref25) 2023; 192 Bi (ref8) 2021; 62 Bartnik (ref3) 2023; 33 Fuchs (ref14) 2019; 40 Abraham (ref1) 2014; 8 Bergsland (ref6) 2021; 96 Smith (ref34) 2009; 106 Desikan (ref13) 2006; 31 Smith (ref33) 2013; 80 Wisdom (ref41) 2011; 32 Jakimovski (ref20) 2020; 26 Hellström-Lindahl (ref17) 1998; 108 Heide (ref16) 2020; 369 Langdon (ref23) 2012; 18 Bethlehem (ref7) 2022; 604 Levine (ref26) 2021; 4 Lamprecht (ref22) 2021; 10 Pastor (ref27) 2023 Possin (ref28) 2010; 16 Rubinov (ref30) 2010; 52 |
References_xml | – volume: 11 start-page: 1006 year: 2012 ident: ref36 article-title: Cognitive reserve in ageing and Alzheimer's disease publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(12)70191-6 contributor: fullname: Stern – volume: 47 start-page: 2015 year: 2009 ident: ref35 article-title: Cognitive reserve publication-title: Neuropsychologia doi: 10.1016/j.neuropsychologia.2009.03.004 contributor: fullname: Stern – volume: 8 start-page: 14 year: 2014 ident: ref1 article-title: Machine learning for neuroimaging with scikit-learn publication-title: Front. Neuroinform. doi: 10.3389/fninf.2014.00014 contributor: fullname: Abraham – volume: 369 start-page: 546 year: 2020 ident: ref16 article-title: Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset publication-title: Science doi: 10.1126/science.abb2401 contributor: fullname: Heide – volume: 24 start-page: 49 year: 2014 ident: ref12 article-title: Functional brain connectivity using fMRI in aging and Alzheimer's disease publication-title: Neuropsychol. Rev. doi: 10.1007/s11065-014-9249-6 contributor: fullname: Dennis – volume: 10 start-page: 66 year: 2018 ident: ref31 article-title: Can visuospatial measures improve the diagnosis of Alzheimer's disease? publication-title: Alzheimer's Dement. doi: 10.1016/j.dadm.2017.10.004 contributor: fullname: Salimi – volume: 286 start-page: 594 year: 2011 ident: ref11 article-title: Function of partially duplicated human α77 nicotinic receptor subunit CHRFAM7A gene: potential implications for the cholinergic anti-inflammatory response publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110.180067 contributor: fullname: de Lucas-Cerrillo – volume: 26 start-page: 201 year: 2020 ident: ref20 article-title: Lower total cerebral arterial flow contributes to cognitive performance in multiple sclerosis patients publication-title: Mult. Scler. J. doi: 10.1177/1352458518819608 contributor: fullname: Jakimovski – volume: 16 start-page: 466 year: 2010 ident: ref28 article-title: Visual spatial cognition in neurodegenerative disease publication-title: Neurocase doi: 10.1080/13554791003730600 contributor: fullname: Possin – volume: 192 start-page: 106783 year: 2023 ident: ref25 article-title: Unanswered questions in the regulation and function of the duplicated α7 nicotinic receptor gene CHRFAM7A publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2023.106783 contributor: fullname: Leonard – volume: 62 start-page: 20 year: 2021 ident: ref8 article-title: Synaptosomal actin dynamics in the developmental visual cortex regulate behavioral visual acuity in rats publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.62.7.20 contributor: fullname: Bi – start-page: 14 year: 2022 ident: ref5 article-title: Alteration of visuospatial system as an early marker of cognitive decline: a double-center neuroimaging study publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2022.854368 contributor: fullname: Berente – volume: 33 start-page: 1987 year: 2012 ident: ref15 article-title: Human brain changes across the life span: a review of 56 longitudinal magnetic resonance imaging studies publication-title: Hum. Brain Mapp. doi: 10.1002/hbm.21334 contributor: fullname: Hedman – volume: 10 start-page: 1795 year: 2021 ident: ref22 article-title: Actin cytoskeleton role in the maintenance of neuronal morphology and long-term memory publication-title: Cells doi: 10.3390/cells10071795 contributor: fullname: Lamprecht – volume: 106 start-page: 13040 year: 2009 ident: ref34 article-title: Correspondence of the brain's functional architecture during activation and rest publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.0905267106 contributor: fullname: Smith – volume: 289 start-page: 26451 year: 2014 ident: ref40 article-title: The duplicated α7 subunits assemble and form functional nicotinic receptors with the full-length α7 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.582858 contributor: fullname: Wang – volume: 80 start-page: 144 year: 2013 ident: ref33 article-title: Resting-state fMRI in the human connectome project publication-title: NeuroImage doi: 10.1016/j.neuroimage.2013.05.039 contributor: fullname: Smith – volume: 16 start-page: 338 year: 2018 ident: ref42 article-title: Neuronal and Extraneuronal nicotinic acetylcholine receptors publication-title: Curr. Neuropharmacol. doi: 10.2174/1570159X15666170912110450 contributor: fullname: Zoli – volume: 59 start-page: 102892 year: 2020 ident: ref37 article-title: CHRFAM7A: a human specific fusion gene, accounts for the translational gap for cholinergic strategies in Alzheimer's disease publication-title: EBioMedicine doi: 10.1016/j.ebiom.2020.102892 contributor: fullname: Szigeti – volume: 95 start-page: 104725 year: 2023 ident: ref38 article-title: Neuronal actin cytoskeleton gain of function in the human brain publication-title: EBioMedicine doi: 10.1016/j.ebiom.2023.104725 contributor: fullname: Szigeti – volume: 87 start-page: 198701 year: 2001 ident: ref24 article-title: Efficient behavior of small-world networks publication-title: Phys. Rev. Lett. doi: 10.1103/PhysRevLett.87.198701 contributor: fullname: Latora – volume: 62 start-page: 1099 year: 2012 ident: ref29 article-title: EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2011.10.024 contributor: fullname: Prickaerts – year: 2023 ident: ref27 article-title: α7 nicotinic acetylcholine receptor in memory processing publication-title: Eur. J. Neurosci. doi: 10.1111/ejn.15913 contributor: fullname: Pastor – volume: 230 start-page: 74 year: 2011 ident: ref4 article-title: Expression of the α7 nAChR subunit duplicate form (CHRFAM7A) is down-regulated in the monocytic cell line THP-1 on treatment with LPS publication-title: J. Neuroimmunol. doi: 10.1016/j.jneuroim.2010.09.008 contributor: fullname: Benfante – volume: 108 start-page: 147 year: 1998 ident: ref17 article-title: Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord publication-title: Brain Res. Dev. Brain Res. doi: 10.1016/S0165-3806(98)00046-7 contributor: fullname: Hellström-Lindahl – volume: 604 start-page: 525 year: 2022 ident: ref7 article-title: Brain charts for the human lifespan publication-title: Nature doi: 10.1038/s41586-022-04554-y contributor: fullname: Bethlehem – volume: 33 start-page: 6090 year: 2023 ident: ref3 article-title: Functional alteration due to structural damage is network dependent: insight from multiple sclerosis publication-title: Cereb. Cortex doi: 10.1093/cercor/bhac486 contributor: fullname: Bartnik – volume: 96 start-page: 4379 year: 2021 ident: ref6 article-title: A deep learning-based approach for simultaneously segmenting T2 lesions and T1 hypointensities in multiple sclerosis regulatory clinical trials (4379) publication-title: Neurology doi: 10.1212/WNL.96.15_supplement.4379 contributor: fullname: Bergsland – volume: 83 start-page: 1345 year: 2014 ident: ref10 article-title: Influence of BDNF Val66Met on the relationship between physical activity and brain volume publication-title: Neurology doi: 10.1212/WNL.0000000000000867 contributor: fullname: Brown – volume: 11 start-page: 664 year: 2021 ident: ref9 article-title: Homomeric and Heteromeric α7 nicotinic acetylcholine receptors in health and some central nervous system diseases publication-title: Membranes (Basel) doi: 10.3390/membranes11090664 contributor: fullname: Borroni – volume: 40 start-page: 5231 year: 2019 ident: ref14 article-title: Preserved network functional connectivity underlies cognitive reserve in multiple sclerosis publication-title: Hum. Brain Mapp. doi: 10.1002/hbm.24768 contributor: fullname: Fuchs – volume: 32 start-page: 63 year: 2011 ident: ref41 article-title: The effects of apolipoprotein E on non-impaired cognitive functioning: a meta-analysis publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2009.02.003 contributor: fullname: Wisdom – volume: 52 start-page: 1059 year: 2010 ident: ref30 article-title: Complex network measures of brain connectivity: uses and interpretations publication-title: NeuroImage doi: 10.1016/j.neuroimage.2009.10.003 contributor: fullname: Rubinov – volume: 18 start-page: 891 year: 2012 ident: ref23 article-title: Recommendations for a brief international cognitive assessment for multiple sclerosis (BICAMS) publication-title: Mult. Scler. doi: 10.1177/1352458511431076 contributor: fullname: Langdon – volume: 31 start-page: 968 year: 2006 ident: ref13 article-title: An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest publication-title: NeuroImage doi: 10.1016/j.neuroimage.2006.01.021 contributor: fullname: Desikan – volume: 96 start-page: 274 year: 2015 ident: ref32 article-title: The human CHRNA7 and CHRFAM7A genes: a review of the genetics, regulation, and function publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2015.02.006 contributor: fullname: Sinkus – volume: 21 start-page: 9668 year: 2020 ident: ref18 article-title: iPSC-derived microglia for modeling human-specific DAMP and PAMP responses in the context of Alzheimer's disease publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms21249668 contributor: fullname: Ihnatovych – volume: 9 start-page: 59 year: 2019 ident: ref19 article-title: iPSC model of CHRFAM7A effect on α7 nicotinic acetylcholine receptor function in the human context publication-title: Transl. Psychiatry doi: 10.1038/s41398-019-0375-z contributor: fullname: Ihnatovych – volume: 76 start-page: 2178 year: 2021 ident: ref21 article-title: Midlife vision impairment and cognitive function in later life: the study of Women's health across the nation, Michigan cohort publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/glab180 contributor: fullname: Kolli – volume: 90 start-page: 695 year: 2018 ident: ref2 article-title: Resistance vs resilience to Alzheimer disease: clarifying terminology for preclinical studies publication-title: Neurology doi: 10.1212/WNL.0000000000005303 contributor: fullname: Arenaza-Urquijo – volume: 12 start-page: 543 year: 2020 ident: ref39 article-title: Activation of α7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway publication-title: Aging (Albany NY) doi: 10.18632/aging.102640 contributor: fullname: Wang – volume: 4 start-page: e210169 year: 2021 ident: ref26 article-title: Sex differences in cognitive decline among US adults publication-title: JAMA Netw. Open doi: 10.1001/jamanetworkopen.2021.0169 contributor: fullname: Levine |
SSID | ssj0062842 |
Score | 2.4098659 |
Snippet | , a uniquely human fusion gene, has been associated with neuropsychiatric disorders including Alzheimer's disease, schizophrenia, anxiety, and attention... Introduction CHRFAM7A , a uniquely human fusion gene, has been associated with neuropsychiatric disorders including Alzheimer’s disease, schizophrenia,... IntroductionCHRFAM7A, a uniquely human fusion gene, has been associated with neuropsychiatric disorders including Alzheimer's disease, schizophrenia, anxiety,... IntroductionCHRFAM7A, a uniquely human fusion gene, has been associated with neuropsychiatric disorders including Alzheimer’s disease, schizophrenia, anxiety,... |
SourceID | doaj pubmedcentral proquest crossref pubmed |
SourceType | Open Website Open Access Repository Aggregation Database Index Database |
StartPage | 1359028 |
SubjectTerms | CHRFAM7A efficiency human brain diversity neuropsychological assessment Neuroscience structural MRI |
SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LSwMxEA7SkxdR62N9EUG8yOI2yb6OVSxF0INU8BbymMUeTMXWg__emexWrAhehD0lC5v9Jsl8Xx4zjJ0pX1kwlNylKk2qbCPT2hR1is4VyrJ0Bh86bXFfjB_V7VP-9C3VF50Ja8MDt8BdqloCGJAZuEKhd6m8berGGoe-u8o74TPIl2KqnYMLnHRFe0UGJVh92YRpoNjcQlGeBwpYsuKGYrT-3yjmz5OS31zPaJNtdJyRD9u2brE1CNusPwyol18--DmPpzjj8nif1XFVnlPGDZzhkE7y6_HDaHhXDjl2FeDTQDRxDnNuKTkEhxhCgu5f7rDJ6GZyPU679AipUyJbpL62InPKNAUAsgz8az9A4CUWuCwHg84eh2zjUVDkBioPFkevzExmoRAAcpf1wizAPuOiBOQFjc8Kh-xIIeQDV3kvfK2EkdIl7GIJln5tg2BoFA8ErY7QaoJWd9Am7Irw_HqTAljHAjSr7syq_zJrwk6X1tDY4WkXwwSYvc-1JNIZXW_C9lrrfH1KovyjyoRVK3ZbactqTZg-x6DapIMzlGsH_9H6Q7ZOiNCukxBHrLd4e4djJC8LexL76ScBBO3o priority: 102 providerName: Directory of Open Access Journals |
Title | Human restricted CHRFAM7A gene increases brain efficiency |
URI | https://www.ncbi.nlm.nih.gov/pubmed/38711941 https://search.proquest.com/docview/3051941303 https://pubmed.ncbi.nlm.nih.gov/PMC11070550 https://doaj.org/article/493eeae30ec648188dbf9fbac2508561 |
Volume | 18 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swED_a7mUvY1v34XULGoy9DDeOpMj2YxqahUFLKR3kzejjvAUWpTTpw_773slxWcaeBsYPko3E3Un3O-k-AD7pUDm0XNylKm2uXavy2po6J-WKZVl6Sw97W1ya-Xf9bTFeHIDpY2GS0753y9P4a3Ualz-Tb-Xtyg97P7Hh1cWUbZaC82sfwmGpVG-jd_uvoQ033XEajgciQN6FypApVg_buIyco1tqrvfAiUv21FHK2v8vqPm3x-QfKmj2HJ7tsKOYdHN8AQcYX8LxJJLdvPotPovkzZmOyY-hTqfzgitv0E5HsFJM59ezyUU5ESQyKJaR4eIGN8JxkQiBKZUEx2G-gpvZ-c10nu_KJORey2Kbh9rJwmvbGkRCG0SBMCIGKGrwxRgtKX1aum0gw2JssQroaBWrwhYOjURUr-EoriO-BSFLJHzQhsJ4Qkla12rkqxBkqLW0SvkMvvTEam67ZBgNGRFM2iaRtmHSNjvSZnDG9Hz8khNZp4b13Y9mx86GxkC0qAr0RhN4qIJr69ZZT9CsImyXwceeGw0JPt9m2Ijr-02jGHwmFZzBm447j0MpMgO5M4Nqj297c9nvIVlLybV72Xr3_7-ewFOmA985SfkejrZ39_iBoMvWDeDJ2fnl1fUgmf70_roYDZL0PgCaB_HN |
link.rule.ids | 230,315,733,786,790,870,891,2115,27955,27956,33778,53825,53827 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwEB4tywEuLLCwZHkZCXFBabO2m8exVFQFtiuEitib5ccEKmi62rYH-PXMOM2KrriAlFOcyI6_ePyNPf4G4KUOpUPLyV3Kwqba1SqtbF6lNLliURTe0sXRFmf55LN-fz4434O8OwsTg_a9m_eaH4teM_8WYysvFr7fxYn1P05H7LNkrK99A27SgJWDzktvLXBOJjfucuZ8IogoeXtYhpyxql8384ZVuqXmjA8sXbIzIUXd_r-Rzesxk39MQuMD-NI1v409-d7brF3P_7qm7Pjv33cX7mx5qRi25fdgD5v7cDhsyCdf_BSvRIwUjUvwh1DFlX_BWT3IihJlFaPJp_FwWgwF_Y4o5g1T0RWuhOMEFAKjTAWf8XwAs_Hb2WiSblMwpF7LbJ2GysnMa1vniMRkqG_DCYGr6IbPBmiJUJBZqAM5LQOLZUBHFkJlNnOYS0T1EPabZYOPQMgCiXvUIcs9MTCtK3XiyxBkqLS0SvkEXncwmItWaMOQg8KgmQiaYdDMFrQE3jBSV0-ySHa8sbz8arZdaagORIsqQ59rIiZlcHVVO-uJ9pXEGxN40eFsaFDxToltcLlZGcXENk7vCRy1uF9VpcjF5MIEyp0_YqctuyWEcxTu7nA9_v9Xn8OtyWx6ak7fnX14DLe5T3hvS8onsL--3OBTokhr9yyOh9_wMxB2 |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwEB7BIiEuvBaW8DQS4oLSZu00j2MpVOWxqxVapJU4WH5MoIK61bY9wK9nxklWdMVppZwSR4n9xeNvMuNvAF7lvrJouLhLVZo0t41Ka1PUKS2uWJalM3RwtsVxMfuafzwbnXVZlesurTI4Ox-EX4tBmP-IuZWrhRv2eWLDk6MJ-ywZ62uvfDO8Djdo0sqy99RbK1yQ2Y2RzoJ3BREtbzfMkENWD5swD6zULXOu-sDyJTuLUtTu_x_hvJw3-c9CNL0D3_outPknPwfbjR24P5fUHa_Wx7twu-OnYty2uQfXMNyH_XEg33zxW7wWMWM0_orfhzpGAARX9yBrStRVTGZfpuOjcizos0QxD0xJ17gWlgtRCIxyFbzX8wGcTt-fTmZpV4ohdbnMNqmvrcxcbpoCkRgNja8_JJAVnXDZCA0RCzIPjSfnZWSw8mjJUqjMZBYLiagewl5YBnwEQpZIHKTxWeGIieV5rQ5d5b30dS6NUi6BNz0UetUKbmhyVBg4HYHTDJzugEvgLaN10ZLFsuOJ5fl33Q2npmcgGlQZuiInglJ529SNNY7oX0X8MYGXPdaaJhdHTEzA5XatFRPcuMwncNBif_EoRa4mX0yg2vkqdt5l9wphHQW8e2wfX_3WF3Dz5N1Uf_5w_OkJ3OIh4RCXlE9hb3O-xWfElDb2eZwSfwGBmxL2 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Human+restricted+CHRFAM7A+gene+increases+brain+efficiency&rft.jtitle=Frontiers+in+neuroscience&rft.au=Jakimovski%2C+Dejan&rft.au=Dorn%2C+Ryu+P&rft.au=Regno%2C+Megan+Del&rft.au=Bartnik%2C+Alexander&rft.date=2024-04-22&rft.issn=1662-4548&rft.volume=18&rft.spage=1359028&rft.epage=1359028&rft_id=info:doi/10.3389%2Ffnins.2024.1359028&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1662-4548&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1662-4548&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1662-4548&client=summon |