Salmonella enterica serovar Paratyphi A-induced immune response in Caenorhabditis elegans depends on MAPK pathways and DAF-16

serovar Paratyphi A ( . Paratyphi A) is a pathogen that can cause enteric fever. According to the recent epidemic trends of typhoid fever, . Paratyphi A has been the major important causative factor in paratyphoid fever. An effective vaccine for . Paratyphi A has not been developed, which made it a...

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Published inFrontiers in immunology Vol. 14; p. 1118003
Main Authors Ding, Ai-Jun, Zhang, Wei-Ming, Tao, Jian, Chen, Bing, Liu, Xiao-Cao, Dong, Yu, Ma, Han-Jing, Pan, Shao-Dong, He, Jiang-Bo, Zeng, Wei-Kun
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 12.04.2023
Subjects
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins - genetics
Forkhead Transcription Factors
immune
Immunity
Immunology
MAPK
oxidative stress
Salmonella enterica serovar Paratyphi A
Salmonella paratyphi A
Typhoid Fever
Typhoid-Paratyphoid Vaccines
Caenorhabditis elegans
Salmonella enterica serovar Paratyphi A
immune
MAPK
oxidative stress
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Abstract serovar Paratyphi A ( . Paratyphi A) is a pathogen that can cause enteric fever. According to the recent epidemic trends of typhoid fever, . Paratyphi A has been the major important causative factor in paratyphoid fever. An effective vaccine for . Paratyphi A has not been developed, which made it a tricky public health concern. Until now, how . Paratyphi A interacts with organisms remain unknown. Here using lifespan assay, we found that . Paratyphi A could infect ( ) at 25°C, and attenuate thermotolerance. The immune response of was mediated by , , , , , , and , suggesting that . Paratyphi A could regulate the MAPK and insulin pathways. Furthermore, we observed several phenotypical changes when were fed . Paratyphi A, including an accelerated decline in body movement, reduced the reproductive capacity, shortened spawning cycle, strong preference for OP50, arrested pharyngeal pumping and colonization of the intestinal lumen. The virulence of . Paratyphi A requires living bacteria and is not mediated by secreting toxin. Using hydrogen peroxide analysis and quantitative RT-PCR, we discovered that . Paratyphi A could increase oxidative stress and regulate the immune response in . . Our results sheds light on the infection mechanisms of . Paratyphi A and lays a foundation for drugs and vaccine development.
AbstractList Salmonella enterica serovar Paratyphi A ( S . Paratyphi A) is a pathogen that can cause enteric fever. According to the recent epidemic trends of typhoid fever, S . Paratyphi A has been the major important causative factor in paratyphoid fever. An effective vaccine for S . Paratyphi A has not been developed, which made it a tricky public health concern. Until now, how S . Paratyphi A interacts with organisms remain unknown. Here using lifespan assay, we found that S . Paratyphi A could infect Caenorhabditis elegans ( C. elegans ) at 25°C, and attenuate thermotolerance. The immune response of C. elegans was mediated by tir-1 , nsy-1 , sek-1 , pmk-1 , mpk-1 , skn-1 , daf-2 and daf-16 , suggesting that S . Paratyphi A could regulate the MAPK and insulin pathways. Furthermore, we observed several phenotypical changes when C. elegans were fed S . Paratyphi A, including an accelerated decline in body movement, reduced the reproductive capacity, shortened spawning cycle, strong preference for OP50, arrested pharyngeal pumping and colonization of the intestinal lumen. The virulence of S . Paratyphi A requires living bacteria and is not mediated by secreting toxin. Using hydrogen peroxide analysis and quantitative RT-PCR, we discovered that S . Paratyphi A could increase oxidative stress and regulate the immune response in C . elegans . Our results sheds light on the infection mechanisms of S . Paratyphi A and lays a foundation for drugs and vaccine development.
Salmonella enterica serovar Paratyphi A (S. Paratyphi A) is a pathogen that can cause enteric fever. According to the recent epidemic trends of typhoid fever, S. Paratyphi A has been the major important causative factor in paratyphoid fever. An effective vaccine for S. Paratyphi A has not been developed, which made it a tricky public health concern. Until now, how S. Paratyphi A interacts with organisms remain unknown. Here using lifespan assay, we found that S. Paratyphi A could infect Caenorhabditis elegans (C. elegans) at 25°C, and attenuate thermotolerance. The immune response of C. elegans was mediated by tir-1, nsy-1, sek-1, pmk-1, mpk-1, skn-1, daf-2 and daf-16, suggesting that S. Paratyphi A could regulate the MAPK and insulin pathways. Furthermore, we observed several phenotypical changes when C. elegans were fed S. Paratyphi A, including an accelerated decline in body movement, reduced the reproductive capacity, shortened spawning cycle, strong preference for OP50, arrested pharyngeal pumping and colonization of the intestinal lumen. The virulence of S. Paratyphi A requires living bacteria and is not mediated by secreting toxin. Using hydrogen peroxide analysis and quantitative RT-PCR, we discovered that S. Paratyphi A could increase oxidative stress and regulate the immune response in C. elegans. Our results sheds light on the infection mechanisms of S. Paratyphi A and lays a foundation for drugs and vaccine development.
serovar Paratyphi A ( . Paratyphi A) is a pathogen that can cause enteric fever. According to the recent epidemic trends of typhoid fever, . Paratyphi A has been the major important causative factor in paratyphoid fever. An effective vaccine for . Paratyphi A has not been developed, which made it a tricky public health concern. Until now, how . Paratyphi A interacts with organisms remain unknown. Here using lifespan assay, we found that . Paratyphi A could infect ( ) at 25°C, and attenuate thermotolerance. The immune response of was mediated by , , , , , , and , suggesting that . Paratyphi A could regulate the MAPK and insulin pathways. Furthermore, we observed several phenotypical changes when were fed . Paratyphi A, including an accelerated decline in body movement, reduced the reproductive capacity, shortened spawning cycle, strong preference for OP50, arrested pharyngeal pumping and colonization of the intestinal lumen. The virulence of . Paratyphi A requires living bacteria and is not mediated by secreting toxin. Using hydrogen peroxide analysis and quantitative RT-PCR, we discovered that . Paratyphi A could increase oxidative stress and regulate the immune response in . . Our results sheds light on the infection mechanisms of . Paratyphi A and lays a foundation for drugs and vaccine development.
Author Chen, Bing
Ding, Ai-Jun
Zhang, Wei-Ming
Tao, Jian
He, Jiang-Bo
Liu, Xiao-Cao
Dong, Yu
Pan, Shao-Dong
Ma, Han-Jing
Zeng, Wei-Kun
AuthorAffiliation School of Medicine, Kunming University , Kunming , China
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  fullname: Zhang, Wei-Ming
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  fullname: Chen, Bing
  organization: School of Medicine, Kunming University, Kunming, China
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  fullname: Liu, Xiao-Cao
  organization: School of Medicine, Kunming University, Kunming, China
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  surname: Zeng
  fullname: Zeng, Wei-Kun
  organization: School of Medicine, Kunming University, Kunming, China
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Cites_doi 10.1016/j.ijbiomac.2021.11.067
10.1101/gad.1324805
10.1371/journal.pntd.0002925
10.3390/cells9010109
10.1016/j.phymed.2019.153061
10.3390/ijms221910741
10.1534/g3.120.401166
10.1016/j.bbrep.2021.100961
10.1007/s11010-016-2884-x
10.1080/21505594.2020.1857982
10.1038/s41598-021-00698-5
10.1093/genetics/77.1.71
10.4161/viru.21808
10.1128/iai.00711-15
10.1111/acel.12867
10.1016/j.ecoenv.2020.110625
10.1126/science.1073759
10.1128/iai.70.9.5202-5207.2002
10.1371/journal.ppat.1010112
10.1002/iid3.369
10.1038/s41586-020-2699-5
10.1016/j.jmii.2021.06.004
10.1016/j.ijid.2022.03.050
10.1371/journal.ppat.1002453
10.1136/bcr.08.2010.3272
10.1093/jtm/taab012
10.3201/eid2305.151539
10.1074/jbc.M109.091629
10.1002/chem.202002401
10.1186/1471-2180-12-49
10.1093/gerona/glw105
10.1371/journal.ppat.1005826
10.1016/j.micinf.2013.03.009
10.1016/j.mib.2014.11.009
10.1038/s41541-017-0037-1
10.1146/annurev-biochem-060815-014451
10.1093/cid/cit723
10.1186/s12866-022-02579-x
10.1039/d0fo00891e
10.1007/s00018-019-03319-7
10.1093/bbb/zbab218
10.1016/j.dci.2011.08.016
10.1177/0049475519863214
10.1016/j.cell.2019.05.024
10.3892/mmr.2018.9590
10.1371/journal.pntd.0010866
10.1111/j.1474-9726.2008.00435.x
10.3855/jidc.12336
10.1016/j.micpath.2022.105936
10.1155/2013/356451
10.1016/j.envpol.2019.113382
10.1016/j.imbio.2019.02.011
10.1016/j.ijid.2005.03.010
10.1016/0531-5565(82)90052-3
10.1111/j.1474-9726.2006.00192.x
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Keywords Caenorhabditis elegans
Salmonella enterica serovar Paratyphi A
immune
MAPK
oxidative stress
Language English
License Copyright © 2023 Ding, Zhang, Tao, Chen, Liu, Dong, Ma, Pan, He and Zeng.
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Edited by: Niyaz Ahmed, University of Hyderabad, India
This article was submitted to Microbial Immunology, a section of the journal Frontiers in Immunology
Reviewed by: Vipin Rana, University of Maryland, College Park, United States; Fan Zhang, Louisiana State University, United States
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References Schiffer (B48) 2021; 17
Gravato-Nobre (B36) 2016; 12
Tsuru (B52) 2022; 86
Hoeven (B46) 2011; 7
Inoue (B41) 2005; 19
Siddiqui (B5) 2006; 10
Vij (B11) 2023; 174
Bhattacharya (B14) 2011; 133
Kaletsky (B38) 2020; 586
Feng (B7) 2021; 55
Wan (B22) 2021; 12
Kumar (B18) 2020; 77
Portal-Celhay (B34) 2012; 12
Xiao (B35) 2021; 22
Kim (B49) 2002; 297
Sun (B12) 2018; 3
Dinić (B21) 2021; 11
Kitisin (B55) 2022; 22
Ooi (B40) 2012; 3
Hosono (B29) 1982; 17
Cohen (B20) 2015; 23
Brenner (B28) 1974; 77
Zhang (B19) 2013; 2013
Pan (B8) 2020; 8
Jansen (B47) 2002; 70
Bhattacharya (B6) 2019; 49
Li (B9) 2022; 16
Wang (B53) 2012; 37
Wilson (B31) 2006; 5
Kim (B39) 2018; 18
Manesh (B2) 2021; 28
Jebamercy (B51) 2013; 15
Dunne (B1) 2011; 2011
Zecic (B25) 2020; 9
Xiao (B56) 2021; 193
Dhara (B13) 2020; 26
Moore (B33) 2019; 177
Das (B10) 2019; 224
Ding (B32) 2017; 426
Zheng (B37) 2017; 72
Mchugh (B54) 2020; 10
Li (B45) 2020; 197
Manoharan (B17) 2022; 119
Yasuda (B44) 2021; 26
Prabhurajan (B16) 2021; 15
Evans (B23) 2008; 7
Riera (B24) 2016; 85
Song (B43) 2020; 11
Yoon (B42) 2019; 18
Arndt (B4) 2014; 8
Bolz (B50) 2010; 285
White (B30) 2016; 84
Meltzer (B15) 2013; 58
Duangjan (B26) 2019; 64
Lu (B3) 2017; 23
Li (B27) 2020; 256
References_xml – volume: 193
  year: 2021
  ident: B56
  article-title: Barley β-glucan resist oxidative stress of caenorhabditis elegans via daf-2/daf-16 pathway
  publication-title: Int J Biol Macromol
  doi: 10.1016/j.ijbiomac.2021.11.067
  contributor:
    fullname: Xiao
– volume: 19
  year: 2005
  ident: B41
  article-title: The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response
  publication-title: Genes Dev
  doi: 10.1101/gad.1324805
  contributor:
    fullname: Inoue
– volume: 8
  year: 2014
  ident: B4
  article-title: Estimating the burden of paratyphoid a in Asia and Africa
  publication-title: PloS Negl Trop Dis
  doi: 10.1371/journal.pntd.0002925
  contributor:
    fullname: Arndt
– volume: 133
  year: 2011
  ident: B14
  article-title: Occurrence & antibiogram of salmonella typhi & s. paratyphi a isolated from rourkela, orissa
  publication-title: Indian J Med Res
  contributor:
    fullname: Bhattacharya
– volume: 9
  start-page: 109
  year: 2020
  ident: B25
  article-title: DAF-16/FoxO in caenorhabditis elegans and its role in metabolic remodeling
  publication-title: Cells
  doi: 10.3390/cells9010109
  contributor:
    fullname: Zecic
– volume: 64
  year: 2019
  ident: B26
  article-title: Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2019.153061
  contributor:
    fullname: Duangjan
– volume: 22
  start-page: 10741
  year: 2021
  ident: B35
  article-title: Pseudomonas donghuensis HYS gtrA/B/II gene cluster contributes to its pathogenicity toward caenorhabditis elegans
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms221910741
  contributor:
    fullname: Xiao
– volume: 10
  year: 2020
  ident: B54
  article-title: DAF-16 and SMK-1 contribute to innate immunity during adulthood in caenorhabditis elegans
  publication-title: G3 (Bethesda)
  doi: 10.1534/g3.120.401166
  contributor:
    fullname: Mchugh
– volume: 26
  year: 2021
  ident: B44
  article-title: Cortisol promotes stress tolerance via DAF-16 in caenorhabditis elegans
  publication-title: Biochem Biophys Rep
  doi: 10.1016/j.bbrep.2021.100961
  contributor:
    fullname: Yasuda
– volume: 426
  year: 2017
  ident: B32
  article-title: Benzimidazole derivative M084 extends the lifespan of caenorhabditis elegans in a DAF-16/FOXO-dependent way
  publication-title: Mol Cell Biochem
  doi: 10.1007/s11010-016-2884-x
  contributor:
    fullname: Ding
– volume: 12
  start-page: 75
  year: 2021
  ident: B22
  article-title: Defective apoptotic cell clearance activates innate immune response to protect caenorhabditis elegans against pathogenic bacteria
  publication-title: Virulence
  doi: 10.1080/21505594.2020.1857982
  contributor:
    fullname: Wan
– volume: 11
  start-page: 21258
  year: 2021
  ident: B21
  article-title: Probiotic-mediated p38 MAPK immune signaling prolongs the survival of caenorhabditis elegans exposed to pathogenic bacteria
  publication-title: Sci Rep
  doi: 10.1038/s41598-021-00698-5
  contributor:
    fullname: Dinić
– volume: 77
  start-page: 71
  year: 1974
  ident: B28
  article-title: The genetics of caenorhabditis elegans
  publication-title: Genetics
  doi: 10.1093/genetics/77.1.71
  contributor:
    fullname: Brenner
– volume: 3
  year: 2012
  ident: B40
  article-title: Burkholderia pseudomallei kills caenorhabditis elegans through virulence mechanisms distinct from intestinal lumen colonization
  publication-title: Virulence
  doi: 10.4161/viru.21808
  contributor:
    fullname: Ooi
– volume: 84
  year: 2016
  ident: B30
  article-title: A stenotrophomonas maltophilia strain evades a major caenorhabditis elegans defense pathway
  publication-title: Infection Immun
  doi: 10.1128/iai.00711-15
  contributor:
    fullname: White
– volume: 18
  year: 2019
  ident: B42
  article-title: MPK-1/ERK is required for the full activity of resveratrol in extended lifespan and reproduction
  publication-title: Aging Cell
  doi: 10.1111/acel.12867
  contributor:
    fullname: Yoon
– volume: 197
  year: 2020
  ident: B45
  article-title: Assessment of nanopolystyrene toxicity under fungal infection condition in caenorhabditis elegans
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2020.110625
  contributor:
    fullname: Li
– volume: 297
  year: 2002
  ident: B49
  article-title: A conserved p38 MAP kinase pathway in caenorhabditis elegans innate immunity
  publication-title: SCIENCE
  doi: 10.1126/science.1073759
  contributor:
    fullname: Kim
– volume: 70
  year: 2002
  ident: B47
  article-title: Hydrogen peroxide-mediated killing of caenorhabditis elegans by streptococcus pyogenes
  publication-title: Infect Immun
  doi: 10.1128/iai.70.9.5202-5207.2002
  contributor:
    fullname: Jansen
– volume: 17
  year: 2021
  ident: B48
  article-title: Modulation of sensory perception by hydrogen peroxide enables caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide
  publication-title: PloS Pathog
  doi: 10.1371/journal.ppat.1010112
  contributor:
    fullname: Schiffer
– volume: 8
  year: 2020
  ident: B8
  article-title: Characterization and protective efficacy of a sptP mutant of salmonella paratyphi a
  publication-title: Immun Inflammation Dis
  doi: 10.1002/iid3.369
  contributor:
    fullname: Pan
– volume: 586
  year: 2020
  ident: B38
  article-title: K C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance
  publication-title: Nature
  doi: 10.1038/s41586-020-2699-5
  contributor:
    fullname: Kaletsky
– volume: 55
  year: 2021
  ident: B7
  article-title: Genomic surveillance reveals international circulation and local transmission of salmonella enterica serovars typhi and paratyphi a in Taiwan
  publication-title: J Microbiol Immunol Infect
  doi: 10.1016/j.jmii.2021.06.004
  contributor:
    fullname: Feng
– volume: 119
  year: 2022
  ident: B17
  article-title: Epidemiology of multidrug resistance among salmonella enterica serovars typhi and paratyphi a at a tertiary pediatric hospital in India over a decade; in-silico approach to elucidate the molecular mechanism of quinolone resistance
  publication-title: Int J Infect Dis
  doi: 10.1016/j.ijid.2022.03.050
  contributor:
    fullname: Manoharan
– volume: 7
  year: 2011
  ident: B46
  article-title: Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans
  publication-title: PloS Pathog
  doi: 10.1371/journal.ppat.1002453
  contributor:
    fullname: Hoeven
– volume: 2011
  start-page: bcr0820103272
  year: 2011
  ident: B1
  article-title: Small bowel perforation secondary to enteric salmonella paratyphi a infection
  publication-title: BMJ Case Rep
  doi: 10.1136/bcr.08.2010.3272
  contributor:
    fullname: Dunne
– volume: 28
  start-page: taab012
  year: 2021
  ident: B2
  article-title: Typhoid and paratyphoid fever: a clinical seminar
  publication-title: J Travel Med
  doi: 10.1093/jtm/taab012
  contributor:
    fullname: Manesh
– volume: 23
  year: 2017
  ident: B3
  article-title: Regional transmission of salmonella paratyphi a, china 1998-2012
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid2305.151539
  contributor:
    fullname: Lu
– volume: 285
  year: 2010
  ident: B50
  article-title: A conserved PMK-1/p38 MAPK is required in caenorhabditis elegans tissue-specific immune response to yersinia pestis infection
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.091629
  contributor:
    fullname: Bolz
– volume: 26
  year: 2020
  ident: B13
  article-title: Syntheses of salmonella paratyphi a associated oligosaccharide antigens and development towards anti-paratyphoid fever vaccines
  publication-title: Chemistry
  doi: 10.1002/chem.202002401
  contributor:
    fullname: Dhara
– volume: 12
  start-page: 49
  year: 2012
  ident: B34
  article-title: Control of intestinal bacterial proliferation in regulation of lifespan in caenorhabditis elegans
  publication-title: BMC Microbiol
  doi: 10.1186/1471-2180-12-49
  contributor:
    fullname: Portal-Celhay
– volume: 72
  year: 2017
  ident: B37
  article-title: Chlorogenic acid extends the lifespan of caenorhabditis elegans via Insulin/IGF-1 signaling pathway
  publication-title: J Gerontol A Biol Sci Med Sci
  doi: 10.1093/gerona/glw105
  contributor:
    fullname: Zheng
– volume: 12
  year: 2016
  ident: B36
  article-title: The invertebrate lysozyme effector ILYS-3 is systemically activated in response to danger signals and confers antimicrobial protection in c. elegans
  publication-title: PloS Pathog
  doi: 10.1371/journal.ppat.1005826
  contributor:
    fullname: Gravato-Nobre
– volume: 15
  year: 2013
  ident: B51
  article-title: A MAP kinase pathway in caenorhabditis elegans is required for defense against infection by opportunistic Proteus species
  publication-title: Microbes Infect
  doi: 10.1016/j.micinf.2013.03.009
  contributor:
    fullname: Jebamercy
– volume: 23
  start-page: 94
  year: 2015
  ident: B20
  article-title: Microbial pathogenesis and host defense in the nematode C. elegans
  publication-title: Curr Opin Microbiol
  doi: 10.1016/j.mib.2014.11.009
  contributor:
    fullname: Cohen
– volume: 3
  year: 2018
  ident: B12
  article-title: Design and production of conjugate vaccines against s. paratyphi a using an O-linked glycosylation system in vivo
  publication-title: NPJ Vaccines
  doi: 10.1038/s41541-017-0037-1
  contributor:
    fullname: Sun
– volume: 85
  start-page: 35
  year: 2016
  ident: B24
  article-title: Signaling networks determining life span
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev-biochem-060815-014451
  contributor:
    fullname: Riera
– volume: 58
  year: 2013
  ident: B15
  article-title: A Large outbreak of salmonella paratyphi a infection among Israeli travelers to Nepal
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/cit723
  contributor:
    fullname: Meltzer
– volume: 22
  start-page: 162
  year: 2022
  ident: B55
  article-title: Caenorhabditis elegans DAF-16 regulates lifespan and immune responses to cryptococcus neoformans and cryptococcus gattii infections
  publication-title: BMC Microbiol
  doi: 10.1186/s12866-022-02579-x
  contributor:
    fullname: Kitisin
– volume: 11
  year: 2020
  ident: B43
  article-title: SKN-1 is involved in combination of apple peels and blueberry extracts synergistically protecting against oxidative stress in caenorhabditis elegans
  publication-title: Food Funct
  doi: 10.1039/d0fo00891e
  contributor:
    fullname: Song
– volume: 77
  year: 2020
  ident: B18
  article-title: Caenorhabditis elegans: a model to understand host-microbe interactions
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-019-03319-7
  contributor:
    fullname: Kumar
– volume: 86
  year: 2022
  ident: B52
  article-title: The defense response of caenorhabditis elegans to cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway
  publication-title: Bioscience Biotechnol Biochem
  doi: 10.1093/bbb/zbab218
  contributor:
    fullname: Tsuru
– volume: 37
  start-page: 193
  year: 2012
  ident: B53
  article-title: Activation of the caenorhabditis elegans FOXO family transcription factor DAF-16 by pathogenic bacillus thuringiensis
  publication-title: Dev Comp Immunol
  doi: 10.1016/j.dci.2011.08.016
  contributor:
    fullname: Wang
– volume: 49
  year: 2019
  ident: B6
  article-title: A sudden increase in occurrence of salmonella paratyphi a infection in rourkela, western odisha
  publication-title: Trop Doct
  doi: 10.1177/0049475519863214
  contributor:
    fullname: Bhattacharya
– volume: 177
  start-page: 1827
  year: 2019
  ident: B33
  article-title: Piwi/PRG-1 argonaute and TGF-beta mediate transgenerational learned pathogenic avoidance
  publication-title: Cell
  doi: 10.1016/j.cell.2019.05.024
  contributor:
    fullname: Moore
– volume: 18
  start-page: 389
  year: 2018
  ident: B39
  article-title: Selenocysteine mimics the effect of dietary restriction on lifespan via SKN1 and retards ageassociated pathophysiological changes in caenorhabditis elegans
  publication-title: Mol Med Rep
  doi: 10.3892/mmr.2018.9590
  contributor:
    fullname: Kim
– volume: 16
  year: 2022
  ident: B9
  article-title: Multiple immunodominant O-epitopes co-expression in live attenuated salmonella serovars induce cross-protective immune responses against s. paratyphi a, s. typhimurium and s. enteritidis
  publication-title: PloS Negl Trop Dis
  doi: 10.1371/journal.pntd.0010866
  contributor:
    fullname: Li
– volume: 7
  year: 2008
  ident: B23
  article-title: The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9726.2008.00435.x
  contributor:
    fullname: Evans
– volume: 15
  year: 2021
  ident: B16
  article-title: Unusual antibiotic resistance pattern among blood culture isolates of salmonella paratyphi a
  publication-title: J Infect Dev Ctries
  doi: 10.3855/jidc.12336
  contributor:
    fullname: Prabhurajan
– volume: 174
  year: 2023
  ident: B11
  article-title: Potential of a novel flagellin epitope as a broad-spectrum vaccine candidate against enteric fever
  publication-title: Microb Pathog
  doi: 10.1016/j.micpath.2022.105936
  contributor:
    fullname: Vij
– volume: 2013
  year: 2013
  ident: B19
  article-title: Host-microbe interactions in caenorhabditis elegans
  publication-title: ISRN Microbiol
  doi: 10.1155/2013/356451
  contributor:
    fullname: Zhang
– volume: 256
  start-page: 113382
  year: 2020
  ident: B27
  article-title: Early-life long-term exposure to ZnO nanoparticles suppresses innate immunity regulated by SKN-1/Nrf and the p38 MAPK signaling pathway in caenorhabditis elegans
  publication-title: Environ pollut
  doi: 10.1016/j.envpol.2019.113382
  contributor:
    fullname: Li
– volume: 224
  year: 2019
  ident: B10
  article-title: Salmonella typhi outer membrane protein STIV is a potential candidate for vaccine development against typhoid and paratyphoid fever
  publication-title: Immunobiology
  doi: 10.1016/j.imbio.2019.02.011
  contributor:
    fullname: Das
– volume: 10
  year: 2006
  ident: B5
  article-title: Typhoid fever in children: some epidemiological considerations from Karachi, Pakistan
  publication-title: Int J Infect Dis
  doi: 10.1016/j.ijid.2005.03.010
  contributor:
    fullname: Siddiqui
– volume: 17
  year: 1982
  ident: B29
  article-title: Life span of the wild and mutant nematode caenorhabditis elegans. effects of sex, sterilization, and temperature
  publication-title: Exp Gerontol
  doi: 10.1016/0531-5565(82)90052-3
  contributor:
    fullname: Hosono
– volume: 5
  year: 2006
  ident: B31
  article-title: Blueberry polyphenols increase lifespan and thermotolerance in caenorhabditis elegans
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9726.2006.00192.x
  contributor:
    fullname: Wilson
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Snippet serovar Paratyphi A ( . Paratyphi A) is a pathogen that can cause enteric fever. According to the recent epidemic trends of typhoid fever, . Paratyphi A has...
Salmonella enterica serovar Paratyphi A ( S . Paratyphi A) is a pathogen that can cause enteric fever. According to the recent epidemic trends of typhoid...
Salmonella enterica serovar Paratyphi A (S. Paratyphi A) is a pathogen that can cause enteric fever. According to the recent epidemic trends of typhoid fever,...
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StartPage 1118003
SubjectTerms Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins - genetics
Forkhead Transcription Factors
immune
Immunity
Immunology
MAPK
oxidative stress
Salmonella enterica serovar Paratyphi A
Salmonella paratyphi A
Typhoid Fever
Typhoid-Paratyphoid Vaccines
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Title Salmonella enterica serovar Paratyphi A-induced immune response in Caenorhabditis elegans depends on MAPK pathways and DAF-16
URI https://www.ncbi.nlm.nih.gov/pubmed/37122724
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Volume 14
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