VSV-Based Vaccines Reduce Virus Shedding and Viral Load in Hamsters Infected with SARS-CoV-2 Variants of Concern

• Published in: Vaccines (Basel) Vol. 10; no. 3; p. 435
• Main Authors: O'Donnell, Kyle L, Gourdine, Tylisha, Fletcher, Paige, Shifflett, Kyle, Furuyama, Wakako, Clancy, Chad S, Marzi, Andrea
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.03.2022; MDPI
• Subjects: Animal welfare; Cloning; Coronaviruses; COVID-19; COVID-19 vaccines; Glycoproteins; Hamsters; Infections; intranasal vaccination; Laboratory animals; Lungs; Medical laboratories; Mutation; Pandemics; Proteins; Public health; Severe acute respiratory syndrome coronavirus 2; Spike protein; Stomatitis; Vaccines; Vectors (Biology); vesicular stomatitis virus; Viral diseases; Viruses; United States > US; COVID-19; intranasal vaccination; severe acute respiratory syndrome coronavirus-2; vesicular stomatitis virus

The continued progression of the COVID-19 pandemic can partly be attributed to the ability of SARS-CoV-2 to mutate and introduce new viral variants. Some of these variants with the potential to spread quickly and conquer the globe are termed variants of concern (VOC). The existing vaccines implement...