Echovirus induces autophagy to promote viral replication via regulating mTOR/ULK1 signaling pathway

• Published in: Frontiers in immunology Vol. 14; p. 1162208
• Main Authors: Wu, Chunchen, Zeng, Luzhi, Yi, Wenfu, Miao, Yuanjiu, Liu, Yihan, Wang, Qiming, Liu, Shi, Peng, Guoping, Zheng, Zhenhua, Xia, Jianbo
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 11.04.2023
• Subjects: autophagy; Autophagy - physiology; Autophagy-Related Protein-1 Homolog - metabolism; echovirus; Echovirus Infections; enterovirus; Enterovirus B, Human - metabolism; Humans; Immunology; Infant; Infant, Newborn; Intracellular Signaling Peptides and Proteins - metabolism; Signal Transduction; TOR Serine-Threonine Kinases - metabolism; viral replication; Virus Replication - physiology; virus-host interaction; viral replication; virus-host interaction; autophagy; enterovirus; echovirus

Among enteroviruses, echovirus can cause severe illnesses in neonates or infants, with high morbidity and mortality. Autophagy, a central component of host defense mechanisms, can function against diverse infections. In the present study, we investigated the interplay between echovirus and autophagy...