Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply - Mocchegiani, Eugenio; Muzzioli, Mario; Giacconi, Robertina; Cipriano, Catia; Gasparini, Nazzarena; Franceschi, Claudio; Gaetti, Remo; Cavalieri, Elisabetta; Suzuki, Hisanori (Mechanisms of ageing and development, 2003)
Keywords: Adult; Aged; Aged, 80 and over; Aging - immunology; Aging - metabolism; Biological and medical sciences; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene Expression; Humans; Immunobiology; Immunosenescence; Infection - drug therapy; Infection - immunology; Infection - metabolism; Interleukin-6 - metabolism; Killer Cells, Natural - immunology; Killer Cells, Natural - metabolism; Lymphocytes - immunology; Lymphocytes - metabolism; Male; Metallothionein - genetics; Metallothionein - metabolism; Metallothioneins; Modulation of the immune response (stimulation, suppression); PARP-1; Poly(ADP-ribose) Polymerases - metabolism; Prognosis; Recurrence; RNA, Messenger - analysis; Successful ageing; Zinc - administration & dosage; Zinc - blood; Zinc supply; Successful ageing; Immunosenescence; PARP-1; Metallothioneins; Zinc supply; Human; Senescence; Cell function; Immunomodulation; Ageing; Zinc; Natural killer cell; Interleukin 6; Supplementation; Elderly; Metallothionein; Immune system