The benefit of 64-MDCT prior to invasive coronary angiography in symptomatic post-CABG patients

• Published in: The International Journal of Cardiovascular Imaging Vol. 23; no. 3; pp. 369 - 377
• Main Authors: Dikkers, R, Willems, T P, Tio, R A, Anthonio, R L, Zijlstra, F, Oudkerk, M
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.06.2007
• Subjects: Accuracy; Aged; Angiography; Arteries; Contrast Media; Coronary Angiography; Coronary artery; Coronary Artery Bypass; Coronary Disease - diagnostic imaging; Coronary Disease - surgery; Coronary Restenosis - diagnostic imaging; Coronary vessels; Diagnostic systems; Female; Grafting; Heart surgery; Humans; Iopamidol - analogs & derivatives; Male; Middle Aged; Occlusion; Patients; Predictive Value of Tests; Recurrence; Sensation; Sensitivity; Sensitivity and Specificity; Stenosis; Stents; Tomography, X-Ray Computed - methods; Trinucleotide repeats
• ISSN: 1569-5794; 1875-8312; 1573-0743
• DOI: 10.1007/s10554-006-9170-z

The purpose of this study is to assess the diagnostic accuracy of 64-MDCT in symptomatic patients after CABG and to explore the advantages of the 64-MDCT results on the CAG procedure. From December 2004 until August 2005, 34 post-CABG patients (29 men, mean age 63.5 +/- 8.5 years) with 69 coronary artery bypass grafts were scanned on a 64-MDCT (Somatom Sensation 64, Siemens AG, Forchheim, Germany) prior to CAG. Angiograms and 64-MDCT images were evaluated for the existence of occlusions or significant stenosis (>or=50% lumen reduction) in bypass grafts and native coronary arteries. 64-MDCT had a sensitivity, a specificity, and a diagnostic accuracy of 100% for occlusion detection. For stenosis detection, sensitivity was 100%, specificity 98.7% and diagnostic accuracy 98.7%. For detecting significant stenosis in native coronary arteries, 64-MDCT had a sensitivity of 80.0%, specificity of 90.8%, and a diagnostic accuracy of 87.1%. Seventeen patients (50.0%) did not need invasive treatment, 14 patients (41.2%) underwent a percutaneous coronary intervention (PCI), and 3 patients (8.8%) underwent surgery. Treatment advice based on 64-MDCT was correct in 88.2% of patients and when 64-MDCT results would have been known 58.8% of diagnostic CAG procedures could have been prevented. In conclusion, 64-MDCT has a high diagnostic accuracy in detecting bypass graft stenosis and occlusions, and 64-MDCT based treatment advice was correct in 88.2% of patients.