From stress fiber to focal adhesion: a role of actin crosslinkers in force transmission

• Published in: Frontiers in cell and developmental biology Vol. 12; p. 1444827
• Main Authors: Katsuta, Hiroki, Sokabe, Masahiro, Hirata, Hiroaki
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 13.08.2024
• Subjects: Cell and Developmental Biology; crosslinking protein; extracellular matrix; focal adhesion; rigidity sensing; stress fiber; viscoelasticity; focal adhesion; rigidity sensing; mechanotransduction; viscoelasticity; cell migration; crosslinking protein; extracellular matrix; stress fiber

The contractile apparatus, stress fiber (SF), is connected to the cell adhesion machinery, focal adhesion (FA), at the termini of SF. The SF-FA complex is essential for various mechanical activities of cells, including cell adhesion to the extracellular matrix (ECM), ECM rigidity sensing, and cell m...