Dorsomorphin attenuates ABCG2-mediated multidrug resistance in colorectal cancer

• Published in: Frontiers in pharmacology Vol. 15; p. 1393693
• Main Authors: Li, Xiao-Peng, Cao, Liang-Qi, Yu, Ze-Zhong, He, Ke, Ding, Peng-Bo, Li, Ji-Sheng, Shan, Yi-Yao, Su, Yu-Bin, Yuan, Zhong-Min, Shi, Zhi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 24.05.2024
• Subjects: ABCG2; chemosensitivity; colorectal cancer; dorsomorphin; multidrug resistance; Pharmacology; multidrug resistance; colorectal cancer; dorsomorphin; chemosensitivity; ABCG2

Colorectal cancer is a common malignant tumor with high mortality, for which chemotherapy resistance is one of the main reasons. The high expression of ABCG2 in the cancer cells and expulsion of anticancer drugs directly cause multidrug resistance (MDR). Therefore, the development of new ABCG2 inhib...