TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer

• Published in: Frontiers in pharmacology Vol. 15; p. 1392328
• Main Authors: Lin, Yanting, Gao, Rui, Jing, Dongquan, Liu, Yiming, Da, Huijuan, Birnbaumer, Lutz, Yang, Yong, Gao, Xinghua, Gao, Zhenhua, Cao, Qiuhua
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 21.05.2024
• Subjects: colorectal cancer; gut microbiota; macrophages; obesity; Pharmacology; TRPC HeptaKO; macrophages; colorectal cancer; TRPC HeptaKO; gut microbiota; obesity

During the past half-century, although numerous interventions for obesity have arisen, the condition’s prevalence has relentlessly escalated annually. Obesity represents a substantial public health challenge, especially due to its robust correlation with co-morbidities, such as colorectal cancer (CR...