Inhibition of 1,2-dimethylhydrazine-induced oxidative DNA damage in rat colon mucosa by black tea complex polyphenols

• Published in: Food and chemical toxicology Vol. 38; no. 12; pp. 1085 - 1088
• Main Authors: Lodovici, M, Casalini, C, De Filippo, C, Copeland, E, Xu, X, Clifford, M, Dolara, P
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.12.2000; New York, NY Elsevier Science
• Subjects: 1,2-Dimethylhydrazine - toxicity; 2-dimethylhydrazine; 8-hydroxy-2′-deoxyguanosine; Alkylating Agents - toxicity; Animals; Antioxidants - pharmacology; Biological and medical sciences; black tea; Carcinogenesis, carcinogens and anticarcinogens; Carcinogens - toxicity; Catechin - analogs & derivatives; Catechin - pharmacology; Chromatography, High Pressure Liquid; Colonic Neoplasms - chemically induced; Colonic Neoplasms - prevention & control; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - analysis; DNA Damage - drug effects; Flavonoids; Foods and miscellaneous; Intestinal Mucosa - drug effects; Male; Medical sciences; oxidative DNA damage; oxygen radicals; Phenols - pharmacology; Phytotherapy; Polymers - pharmacology; Polyphenols; Rats; Rats, Inbred F344; Tea - chemistry; Tea - therapeutic use; theafulvin; thearubigin; Tumors; polyphenols; 2-dimethylhydrazine; TFu; oxidative DNA damage; 8-hydroxy-2′-deoxyguanosine; oxygen radicals; 1; 2dG; theafulvin; thearubigin; DMH; TR; 8-OHdG; Rat; Rodentia; Malignant tumor; Anticarcinogen; Antioxidant; Biological activity; Colonic disease; Tea; Vertebrata; Polyphenol; Mammalia; Animal; DNA; Plant origin; Digestive diseases; Intestinal disease; Colon; Mechanism of action

The effect of black tea polyphenols on 1,2-dimethylhydrazine (DMH)-induced oxidative DNA damage in rat colon mucosa has been investigated. Fischer 344 rats were treated orally with thearubigin (TR) or theafulvin (TFu) for 10 days (40 mg/kg), injected ip with DMH (20 mg/kg) or saline and sacrificed 2...