Humoral Immune Response in Acute Hepatitis C Virus Infection

• Published in: Clinical infectious diseases Vol. 41; no. 5; pp. 667 - 675
• Main Authors: Netski, Dale M., Mosbruger, Tim, Depla, Erik, Maertens, Geert, Ray, Stuart C., Hamilton, Robert G., Roundtree, Stacy, Thomas, David L., McKeating, Jane, Cox, Andrea
• Format: Journal Article
• Language: English
• Published: United States The University of Chicago Press 01.09.2005; University of Chicago Press; Oxford University Press
• Subjects: Acute Disease; Adult; Antibodies; Antibody Formation - immunology; Antigens; Enzyme linked immunosorbent assay; Female; Glycoproteins; Hepacivirus; Hepatitis; Hepatitis C; Hepatitis C - immunology; Hepatitis C Antibodies - blood; Humans; Humoral immunity; Immune system; Immunoglobulin G - blood; Infections; Major Articles; Male; RNA; RNA, Viral - blood; Time Factors; Viral Proteins - immunology; Viremia; Viruses

Background. There is little information on the timing, magnitude, specificity, and clinical relevance of the antibody response to acute hepatitis C virus (HCV) infection. We investigated the specificity, titer, and neutralizing potential of antibody responses to acute infection by examining 12 injec...