Prognostic impact of tumor-associated macrophage infiltration in non-small cell lung cancer: A systemic review and meta-analysis
Tumor-associated macrophages (TAMs) are important components of cancer microenvironment. In the present study, we searched PubMed, Embase, Cochrane library and Web of Science to perform a meta-analysis of 20 studies including a total of 2,572 non-small cell lung cancer (NSCLC) patients, in order to...
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| Published in | Oncotarget Vol. 7; no. 23; pp. 34217 - 34228 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Impact Journals LLC
07.06.2016
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| Abstract | Tumor-associated macrophages (TAMs) are important components of cancer microenvironment. In the present study, we searched PubMed, Embase, Cochrane library and Web of Science to perform a meta-analysis of 20 studies including a total of 2,572 non-small cell lung cancer (NSCLC) patients, in order to determine the association between TAMs and NSCLC prognosis. The combined hazard ratio (HR) of 9 studies showed that the density of total CD68+ TAMs in the tumor islet and stroma was not associated with overall survival (OS) of the patients. However, the pooled HR of 4 studies showed that high density of CD68+ TAMs in the tumor islet predicted better OS, while the pooled HR of 6 studies showed that high density of CD68+ TAMs in the tumor stroma was associated with poor OS. A high islet/stroma ratio of CD68+ TAMs was associated with better OS. A high density of M1 TAMs in the tumor islet was associated with better OS, while a high density of M2 TAMs in the tumor stroma predicted poor OS. These findings suggest that, although the density of total CD68+ TAMs is not associated with OS, the localization and M1/M2 polarization of TAMs are potential prognostic predictors of NSCLC. |
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| AbstractList | Tumor-associated macrophages (TAMs) are important components of cancer microenvironment. In the present study, we searched PubMed, Embase, Cochrane library and Web of Science to perform a meta-analysis of 20 studies including a total of 2,572 non-small cell lung cancer (NSCLC) patients, in order to determine the association between TAMs and NSCLC prognosis. The combined hazard ratio (HR) of 9 studies showed that the density of total CD68+ TAMs in the tumor islet and stroma was not associated with overall survival (OS) of the patients. However, the pooled HR of 4 studies showed that high density of CD68+ TAMs in the tumor islet predicted better OS, while the pooled HR of 6 studies showed that high density of CD68+ TAMs in the tumor stroma was associated with poor OS. A high islet/stroma ratio of CD68+ TAMs was associated with better OS. A high density of M1 TAMs in the tumor islet was associated with better OS, while a high density of M2 TAMs in the tumor stroma predicted poor OS. These findings suggest that, although the density of total CD68+ TAMs is not associated with OS, the localization and M1/M2 polarization of TAMs are potential prognostic predictors of NSCLC. Tumor-associated macrophages (TAMs) are important components of cancer microenvironment. In the present study, we searched PubMed, Embase, Cochrane library and Web of Science to perform a meta-analysis of 20 studies including a total of 2,572 non-small cell lung cancer (NSCLC) patients, in order to determine the association between TAMs and NSCLC prognosis. The combined hazard ratio (HR) of 9 studies showed that the density of total CD68 + TAMs in the tumor islet and stroma was not associated with overall survival (OS) of the patients. However, the pooled HR of 4 studies showed that high density of CD68 + TAMs in the tumor islet predicted better OS, while the pooled HR of 6 studies showed that high density of CD68 + TAMs in the tumor stroma was associated with poor OS. A high islet/stroma ratio of CD68 + TAMs was associated with better OS. A high density of M1 TAMs in the tumor islet was associated with better OS, while a high density of M2 TAMs in the tumor stroma predicted poor OS. These findings suggest that, although the density of total CD68 + TAMs is not associated with OS, the localization and M1/M2 polarization of TAMs are potential prognostic predictors of NSCLC. |
| Author | Guo, Chenglin Liao, Hu You, Zongbing Mei, Jiandong Ma, Lin Xiao, Zhilan Pu, Qiang Liu, Chengwu Liu, Lunxu Lin, Feng |
| AuthorAffiliation | 2 Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University, Chengdu 610041, China 3 Department of Structural and Cellular Biology, Tulane University, New Orleans, LA 70112, USA 1 Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China |
| AuthorAffiliation_xml | – name: 2 Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University, Chengdu 610041, China – name: 1 Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China – name: 3 Department of Structural and Cellular Biology, Tulane University, New Orleans, LA 70112, USA |
| Author_xml | – sequence: 1 givenname: Jiandong surname: Mei fullname: Mei, Jiandong organization: Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University, Chengdu 610041, China – sequence: 2 givenname: Zhilan surname: Xiao fullname: Xiao, Zhilan organization: Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University, Chengdu 610041, China – sequence: 3 givenname: Chenglin surname: Guo fullname: Guo, Chenglin organization: Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University, Chengdu 610041, China – sequence: 4 givenname: Qiang surname: Pu fullname: Pu, Qiang organization: Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University, Chengdu 610041, China – sequence: 5 givenname: Lin surname: Ma fullname: Ma, Lin organization: Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University, Chengdu 610041, China – sequence: 6 givenname: Chengwu surname: Liu fullname: Liu, Chengwu organization: Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University, Chengdu 610041, China – sequence: 7 givenname: Feng surname: Lin fullname: Lin, Feng organization: Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University, Chengdu 610041, China – sequence: 8 givenname: Hu surname: Liao fullname: Liao, Hu organization: Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University, Chengdu 610041, China – sequence: 9 givenname: Zongbing surname: You fullname: You, Zongbing organization: Department of Structural and Cellular Biology, Tulane University, New Orleans, LA 70112, USA – sequence: 10 givenname: Lunxu surname: Liu fullname: Liu, Lunxu organization: Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University, Chengdu 610041, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27144518$$D View this record in MEDLINE/PubMed |
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| Keywords | clinicopathological characteristics prognosis non-small cell lung cancer (NSCLC) tumor-associated macrophages (TAMs) |
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| SubjectTerms | Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Humans Lung Neoplasms - immunology Lung Neoplasms - mortality Lung Neoplasms - pathology Macrophages - immunology Macrophages - pathology Prognosis Research Paper Tumor Microenvironment - immunology |
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