Genome analysis of Bifidobacterium adolescentis and investigation of its effects on inflammation and intestinal barrier function
Numerous studies have confirmed that gut microbiota is a key driver in the occurrence and progression of inflammatory bowel disease (IBD). Based on the bacterial collection constructed in our previous studies, we founded that Bifidobacterium adolescentis AF91-08b2A has the potential beneficial funct...
Saved in:
| Published in | Frontiers in microbiology Vol. 15; p. 1496280 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
22.01.2025
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Numerous studies have confirmed that gut microbiota is a key driver in the occurrence and progression of inflammatory bowel disease (IBD). Based on the bacterial collection constructed in our previous studies, we founded that
Bifidobacterium adolescentis
AF91-08b2A has the potential beneficial function. We designed cohort studies, genomic studies and animal experiments to further explore the probiotic function of
Bifidobacterium adolescentis
AF91-08b2A and its therapeutic effect on IBD. The depletion of
B. adolescentis
in individuals with IBD suggested its significance for intestinal health. Genomic analysis highlighted the probiotic attributes of
B. adolescentis
AF91-08b2A, including resistance to antibiotics and stress, and metabolic pathways related to energy and carbohydrate metabolism, which are likely to enhance its therapeutic efficacy. In DSS-induced mice colitis model, the strain significantly enhanced the disease activity index (DAI), curbed weight loss, and attenuated colonic damage. It effectively modulated the immune response by reducing the levels of pro-inflammatory cytokines such as IL-6, IL-1β, IL-17A, IFN-γ, and TNF-α, while promoting the secretion of anti-inflammatory cytokines like IL-4, IL-10, and TGF-β1. The restoration of tight junction proteins ZO-1, occludin, and claudin-2 by
B. adolescentis
AF91-08b2A demonstrated its capacity to safeguard the intestinal epithelial barrier. Collectively, our findings indicate
B. adolescentis
AF91-08b2A as a valuable therapeutic option for UC, with its multifaceted approach to reducing inflammation and fortifying the intestinal barrier. |
|---|---|
| AbstractList | Numerous studies have confirmed that gut microbiota is a key driver in the occurrence and progression of inflammatory bowel disease (IBD). Based on the bacterial collection constructed in our previous studies, we founded that
Bifidobacterium adolescentis
AF91-08b2A has the potential beneficial function. We designed cohort studies, genomic studies and animal experiments to further explore the probiotic function of
Bifidobacterium adolescentis
AF91-08b2A and its therapeutic effect on IBD. The depletion of
B. adolescentis
in individuals with IBD suggested its significance for intestinal health. Genomic analysis highlighted the probiotic attributes of
B. adolescentis
AF91-08b2A, including resistance to antibiotics and stress, and metabolic pathways related to energy and carbohydrate metabolism, which are likely to enhance its therapeutic efficacy. In DSS-induced mice colitis model, the strain significantly enhanced the disease activity index (DAI), curbed weight loss, and attenuated colonic damage. It effectively modulated the immune response by reducing the levels of pro-inflammatory cytokines such as IL-6, IL-1β, IL-17A, IFN-γ, and TNF-α, while promoting the secretion of anti-inflammatory cytokines like IL-4, IL-10, and TGF-β1. The restoration of tight junction proteins ZO-1, occludin, and claudin-2 by
B. adolescentis
AF91-08b2A demonstrated its capacity to safeguard the intestinal epithelial barrier. Collectively, our findings indicate
B. adolescentis
AF91-08b2A as a valuable therapeutic option for UC, with its multifaceted approach to reducing inflammation and fortifying the intestinal barrier. Numerous studies have confirmed that gut microbiota is a key driver in the occurrence and progression of inflammatory bowel disease (IBD). Based on the bacterial collection constructed in our previous studies, we founded that Bifidobacterium adolescentis AF91-08b2A has the potential beneficial function. We designed cohort studies, genomic studies and animal experiments to further explore the probiotic function of Bifidobacterium adolescentis AF91-08b2A and its therapeutic effect on IBD. The depletion of B. adolescentis in individuals with IBD suggested its significance for intestinal health. Genomic analysis highlighted the probiotic attributes of B. adolescentis AF91-08b2A, including resistance to antibiotics and stress, and metabolic pathways related to energy and carbohydrate metabolism, which are likely to enhance its therapeutic efficacy. In DSS-induced mice colitis model, the strain significantly enhanced the disease activity index (DAI), curbed weight loss, and attenuated colonic damage. It effectively modulated the immune response by reducing the levels of pro-inflammatory cytokines such as IL-6, IL-1β, IL-17A, IFN-γ, and TNF-α, while promoting the secretion of anti-inflammatory cytokines like IL-4, IL-10, and TGF-β1. The restoration of tight junction proteins ZO-1, occludin, and claudin-2 by B. adolescentis AF91-08b2A demonstrated its capacity to safeguard the intestinal epithelial barrier. Collectively, our findings indicate B. adolescentis AF91-08b2A as a valuable therapeutic option for UC, with its multifaceted approach to reducing inflammation and fortifying the intestinal barrier. Numerous studies have confirmed that gut microbiota is a key driver in the occurrence and progression of inflammatory bowel disease (IBD). Based on the bacterial collection constructed in our previous studies, we founded that Bifidobacterium adolescentis AF91-08b2A has the potential beneficial function. We designed cohort studies, genomic studies and animal experiments to further explore the probiotic function of Bifidobacterium adolescentis AF91-08b2A and its therapeutic effect on IBD. The depletion of B. adolescentis in individuals with IBD suggested its significance for intestinal health. Genomic analysis highlighted the probiotic attributes of B. adolescentis AF91-08b2A, including resistance to antibiotics and stress, and metabolic pathways related to energy and carbohydrate metabolism, which are likely to enhance its therapeutic efficacy. In DSS-induced mice colitis model, the strain significantly enhanced the disease activity index (DAI), curbed weight loss, and attenuated colonic damage. It effectively modulated the immune response by reducing the levels of pro-inflammatory cytokines such as IL-6, IL-1β, IL-17A, IFN-γ, and TNF-α, while promoting the secretion of anti-inflammatory cytokines like IL-4, IL-10, and TGF-β1. The restoration of tight junction proteins ZO-1, occludin, and claudin-2 by B. adolescentis AF91-08b2A demonstrated its capacity to safeguard the intestinal epithelial barrier. Collectively, our findings indicate B. adolescentis AF91-08b2A as a valuable therapeutic option for UC, with its multifaceted approach to reducing inflammation and fortifying the intestinal barrier.Numerous studies have confirmed that gut microbiota is a key driver in the occurrence and progression of inflammatory bowel disease (IBD). Based on the bacterial collection constructed in our previous studies, we founded that Bifidobacterium adolescentis AF91-08b2A has the potential beneficial function. We designed cohort studies, genomic studies and animal experiments to further explore the probiotic function of Bifidobacterium adolescentis AF91-08b2A and its therapeutic effect on IBD. The depletion of B. adolescentis in individuals with IBD suggested its significance for intestinal health. Genomic analysis highlighted the probiotic attributes of B. adolescentis AF91-08b2A, including resistance to antibiotics and stress, and metabolic pathways related to energy and carbohydrate metabolism, which are likely to enhance its therapeutic efficacy. In DSS-induced mice colitis model, the strain significantly enhanced the disease activity index (DAI), curbed weight loss, and attenuated colonic damage. It effectively modulated the immune response by reducing the levels of pro-inflammatory cytokines such as IL-6, IL-1β, IL-17A, IFN-γ, and TNF-α, while promoting the secretion of anti-inflammatory cytokines like IL-4, IL-10, and TGF-β1. The restoration of tight junction proteins ZO-1, occludin, and claudin-2 by B. adolescentis AF91-08b2A demonstrated its capacity to safeguard the intestinal epithelial barrier. Collectively, our findings indicate B. adolescentis AF91-08b2A as a valuable therapeutic option for UC, with its multifaceted approach to reducing inflammation and fortifying the intestinal barrier. Numerous studies have confirmed that gut microbiota is a key driver in the occurrence and progression of inflammatory bowel disease (IBD). Based on the bacterial collection constructed in our previous studies, we founded that AF91-08b2A has the potential beneficial function. We designed cohort studies, genomic studies and animal experiments to further explore the probiotic function of AF91-08b2A and its therapeutic effect on IBD. The depletion of in individuals with IBD suggested its significance for intestinal health. Genomic analysis highlighted the probiotic attributes of AF91-08b2A, including resistance to antibiotics and stress, and metabolic pathways related to energy and carbohydrate metabolism, which are likely to enhance its therapeutic efficacy. In DSS-induced mice colitis model, the strain significantly enhanced the disease activity index (DAI), curbed weight loss, and attenuated colonic damage. It effectively modulated the immune response by reducing the levels of pro-inflammatory cytokines such as IL-6, IL-1β, IL-17A, IFN-γ, and TNF-α, while promoting the secretion of anti-inflammatory cytokines like IL-4, IL-10, and TGF-β1. The restoration of tight junction proteins ZO-1, occludin, and claudin-2 by AF91-08b2A demonstrated its capacity to safeguard the intestinal epithelial barrier. Collectively, our findings indicate AF91-08b2A as a valuable therapeutic option for UC, with its multifaceted approach to reducing inflammation and fortifying the intestinal barrier. |
| Author | Zou, Yuanqiang Wang, Haoyu You, Xinbi Xia, Binbin Hu, Tongyuan Yang, Jinlong Sun, Yang Yuan, Yue Miao, Yinglei Li, Bo Wang, Mengmeng Li, Shangyong Liang, Hewei |
| AuthorAffiliation | 4 College of Life Sciences, University of Chinese Academy of Sciences , Beijing , China 6 BGI Research , Wuhan , China 8 BGI Research , Kunming , China 10 Yunnan Geriatric Medical Center , Kunming , China 1 Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University , Kunming , China 3 BGI Research , Shenzhen , China 5 School of Basic Medicine, Qingdao Medical College, Qingdao University , Qingdao , China 2 Yunnan Province Clinical Research Center for Digestive Diseases , Kunming , China 7 Shenzhen Engineering Laboratory of Detection and Intervention of Human Intestinal Microbiome, BGI Research , Shenzhen , China 9 College of Forensic Science, Xi’an Jiaotong University , Xi’an , China |
| AuthorAffiliation_xml | – name: 9 College of Forensic Science, Xi’an Jiaotong University , Xi’an , China – name: 3 BGI Research , Shenzhen , China – name: 1 Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University , Kunming , China – name: 10 Yunnan Geriatric Medical Center , Kunming , China – name: 6 BGI Research , Wuhan , China – name: 4 College of Life Sciences, University of Chinese Academy of Sciences , Beijing , China – name: 2 Yunnan Province Clinical Research Center for Digestive Diseases , Kunming , China – name: 8 BGI Research , Kunming , China – name: 5 School of Basic Medicine, Qingdao Medical College, Qingdao University , Qingdao , China – name: 7 Shenzhen Engineering Laboratory of Detection and Intervention of Human Intestinal Microbiome, BGI Research , Shenzhen , China |
| Author_xml | – sequence: 1 givenname: Bo surname: Li fullname: Li, Bo – sequence: 2 givenname: Haoyu surname: Wang fullname: Wang, Haoyu – sequence: 3 givenname: Mengmeng surname: Wang fullname: Wang, Mengmeng – sequence: 4 givenname: Hewei surname: Liang fullname: Liang, Hewei – sequence: 5 givenname: Tongyuan surname: Hu fullname: Hu, Tongyuan – sequence: 6 givenname: Jinlong surname: Yang fullname: Yang, Jinlong – sequence: 7 givenname: Shangyong surname: Li fullname: Li, Shangyong – sequence: 8 givenname: Xinbi surname: You fullname: You, Xinbi – sequence: 9 givenname: Binbin surname: Xia fullname: Xia, Binbin – sequence: 10 givenname: Yue surname: Yuan fullname: Yuan, Yue – sequence: 11 givenname: Yuanqiang surname: Zou fullname: Zou, Yuanqiang – sequence: 12 givenname: Yinglei surname: Miao fullname: Miao, Yinglei – sequence: 13 givenname: Yang surname: Sun fullname: Sun, Yang |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39911710$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVUsFuFSEUJabG1tofcGFm6ea9MsAww8poo7VJk240cUcucHnSzECFeU2689NlOs-mZQHknnPPJYfzlhzFFJGQ9y3dcj6ocz8Fa7aMMrFthZJsoK_ISSul2HDKfh09ux-Ts1JuaV2Csrq_IcdcqbbtW3pC_l5iTBM2EGF8KKE0yTdfgg8uGbAz5rCfGnBpxGIxzhWH6JoQ77HMYQdzSHHpCHNp0Hu09ayVEP0I07TCa8O8NNQZjYGcA-bG76Nd8HfktYex4NnhPCU_v339cfF9c31zeXXx-XpjBaPzxlCmABQV2HnWS264dJ1jQLnquBGuU874vu2d7xgCdlifP0hmrBIDtdbxU3K16roEt_ouhwnyg04Q9GMh5Z2GPAc7om7RWMaMdEM_CMHdwJAPXHkALztPsWp9WrXu9mZCtziTYXwh-hKJ4bfepXtdTVeCdaoqfDwo5PRnX73RU6gOjyNETPuieSv5IKViXaV-eD7sacr_P6wEthJsTqVk9E-UluolK_oxK3rJij5khf8D_Ka20w |
| Cites_doi | 10.1016/j.medmic.2021.100039 10.1126/science.1109051 10.1038/s41575-019-0258-z 10.3390/foods12050922 10.3390/nu14245233 10.3390/ijms24021526 10.1080/19490976.2023.2291164 10.1080/10408398.2022.2054934 10.1111/asj.13357 10.1186/s13059-019-1891-0 10.1007/s00253-020-10633-9 10.1186/s13046-023-02746-6 10.3390/nu11040819 10.1016/S0140-6736(23)00966-2 10.3390/microorganisms11071649 10.1038/s41571-023-00766-x 10.1016/j.lwt.2023.114759 10.3390/nu14183671 10.3389/fimmu.2021.741934 10.4161/gmic.2.4.17863 10.1017/S0029665114001463 10.3389/fimmu.2021.761981 10.1038/s41575-020-0331-7 10.1038/ajgsup.2012.4 10.3390/microorganisms10020273 10.1080/19490976.2020.1826746 10.1017/S0029665120006916 10.1002/imt2.174 10.1007/s00018-022-04471-3 10.1080/19490976.2021.1949096 10.1093/jn/121.11.1787 10.1101/051813 10.1126/science.aai8132 10.1016/j.chom.2021.12.003 10.1038/s41577-024-01014-8 10.1186/s12864-020-6749-z 10.1163/18762891-20230030 10.3389/fmicb.2023.1211271 10.1016/j.fshw.2022.10.028 10.1016/j.autrev.2021.103017 10.1007/s12272-013-0141-3 10.1111/all.15644 10.1093/gigascience/gix050 10.1016/j.femsre.2004.09.003 10.1093/database/baaa055 10.1016/B978-0-12-407697-6.00002-7 10.1038/s41564-018-0306-4 10.1038/s41467-023-37396-x 10.1039/d2fo01448c 10.1038/s41587-018-0008-8 10.1042/bj2310713 10.1016/j.chom.2015.09.008 10.1016/j.tim.2023.11.007 10.1038/s41598-019-55290-9 10.1053/j.gastro.2019.11.294 10.16288/j.yczz.20-080 |
| ContentType | Journal Article |
| Copyright | Copyright © 2025 Li, Wang, Wang, Liang, Hu, Yang, Li, You, Xia, Yuan, Zou, Miao and Sun. Copyright © 2025 Li, Wang, Wang, Liang, Hu, Yang, Li, You, Xia, Yuan, Zou, Miao and Sun. 2025 Li, Wang, Wang, Liang, Hu, Yang, Li, You, Xia, Yuan, Zou, Miao and Sun |
| Copyright_xml | – notice: Copyright © 2025 Li, Wang, Wang, Liang, Hu, Yang, Li, You, Xia, Yuan, Zou, Miao and Sun. – notice: Copyright © 2025 Li, Wang, Wang, Liang, Hu, Yang, Li, You, Xia, Yuan, Zou, Miao and Sun. 2025 Li, Wang, Wang, Liang, Hu, Yang, Li, You, Xia, Yuan, Zou, Miao and Sun |
| DBID | AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.3389/fmicb.2024.1496280 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1664-302X |
| ExternalDocumentID | oai_doaj_org_article_1ebc22b6d878443d82e3839faaf65f0e PMC11794259 39911710 10_3389_fmicb_2024_1496280 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: “Xingdian Talents” Support Project of Yunnan Province grantid: RLQB20220006 – fundername: Major Science and Technology Special Plan of Yunnan Province grantid: 202302AA310025 – fundername: Shenzhen Municipal Government of China grantid: XMHT20220104017 – fundername: Applied Basic Research Projects of Yunnan Province of China grantid: 202201AW070019 |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ACXDI ADBBV ADRAZ AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK ECGQY GROUPED_DOAJ GX1 HYE KQ8 M48 M~E O5R O5S OK1 PGMZT RNS RPM IPNFZ NPM RIG 7X8 5PM |
| ID | FETCH-LOGICAL-c420t-b029aa904e5f2763b36d5d2a03953b4d59dbf717df52eae5ebac862bc9480ccd3 |
| IEDL.DBID | M48 |
| ISSN | 1664-302X |
| IngestDate | Wed Aug 27 01:31:27 EDT 2025 Thu Aug 21 18:38:33 EDT 2025 Fri Jul 11 05:21:56 EDT 2025 Thu Apr 03 07:06:37 EDT 2025 Tue Jul 01 01:53:42 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Bifidobacterium adolescentis probiotic function intestinal barrier function inflammatory bowel disease genomic analysis |
| Language | English |
| License | Copyright © 2025 Li, Wang, Wang, Liang, Hu, Yang, Li, You, Xia, Yuan, Zou, Miao and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c420t-b029aa904e5f2763b36d5d2a03953b4d59dbf717df52eae5ebac862bc9480ccd3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors have contributed equally to this work Reviewed by: Zhongyue Yang, Stanford University, United States Edited by: Mitesh Patel, Parul University, India Honghua Hu, Macquarie University, Australia |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.3389/fmicb.2024.1496280 |
| PMID | 39911710 |
| PQID | 3163866925 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_1ebc22b6d878443d82e3839faaf65f0e pubmedcentral_primary_oai_pubmedcentral_nih_gov_11794259 proquest_miscellaneous_3163866925 pubmed_primary_39911710 crossref_primary_10_3389_fmicb_2024_1496280 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2025-01-22 |
| PublicationDateYYYYMMDD | 2025-01-22 |
| PublicationDate_xml | – month: 01 year: 2025 text: 2025-01-22 day: 22 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in microbiology |
| PublicationTitleAlternate | Front Microbiol |
| PublicationYear | 2025 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Beresford-Jones (ref3) 2022; 30 He (ref19) 2023; 63 Wang (ref49) 2022; 13 Feng (ref12) 2022; 14 Martin-Gallausiaux (ref40) 2021; 80 Zhao (ref55) 2020; 104 Sonnenburg (ref45) 2005; 307 Ardawi (ref1) 1985; 231 Stewart (ref46) 1977; 35 Nakase (ref41) 2022; 21 Saez (ref43) 2023; 24 Wong (ref52) 2023; 20 Lavelle (ref30) 2020; 17 Boucard (ref5) 2022; 10 Jie (ref25) 2021; 8 Guo (ref17) 2020; 2020 Sartor (ref44) 2012; 1 Wei (ref50) 2023; 12 Fan (ref11) 2021; 13 Wood (ref53) 2019; 20 Kaur (ref26) 2011; 2 Jang (ref23) 2019; 11 Zou (ref56) 2019; 37 Chen (ref7) 2021; 12 Franzosa (ref15) 2018; 4 Niu (ref42) 2022; 14 Gavzy (ref16) 2023; 15 Lewis (ref34) 2015; 18 Le Berre (ref31) 2023; 402 Kennedy (ref27) 2023; 32 Chen (ref9) 2020; 42 Kudelka (ref29) 2020; 17 Lin (ref35) 2023; 42 Fleming (ref13) 1991; 121 He (ref18) 2017; 6 Lee (ref32) 2013; 36 Su (ref47) 2023; 78 Begley (ref2) 2005; 29 Huang (ref21) 2022; 79 Jiang (ref24) 2020; 21 Lu (ref38) 2016; 3 Pittayanon (ref9001) 2020; 158 Ivanov (ref22) 2013; 303 Bosurgi (ref4) 2017; 356 Wen (ref51) 2021; 12 Mann (ref39) 2024; 24 Di Pierro (ref10) 2023; 11 Leser (ref33) 2023; 14 Flint (ref14) 2015; 74 Caparrós (ref6) 2021; 13 Huang (ref20) 2023; 14 Kowalska-Duplaga (ref28) 2019; 9 Lin (ref37) 2024; 3 Chen (ref8) 2023; 12 Suzuki (ref48) 2020; 91 Wu (ref54) 2023; 184 Lin (ref36) 2023; 14 |
| References_xml | – volume: 8 start-page: 100039 year: 2021 ident: ref25 article-title: A transomic cohort as a reference point for promoting a healthy human gut microbiome publication-title: Med. Microecol. doi: 10.1016/j.medmic.2021.100039 – volume: 307 start-page: 1955 year: 2005 ident: ref45 article-title: Glycan foraging in vivo by an intestine-adapted bacterial symbiont publication-title: Science doi: 10.1126/science.1109051 – volume: 17 start-page: 223 year: 2020 ident: ref30 article-title: Gut microbiota-derived metabolites as key actors in inflammatory bowel disease publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/s41575-019-0258-z – volume: 12 start-page: 922 year: 2023 ident: ref50 article-title: Genetic-phenotype analysis of Bifidobacterium bifidum and its glycoside hydrolase gene distribution at different age groups publication-title: Foods doi: 10.3390/foods12050922 – volume: 14 start-page: 5233 year: 2022 ident: ref12 article-title: Heat-killed Bifidobacterium bifidum B1628 may alleviate dextran sulfate sodium-induced colitis in mice, and the anti-inflammatory effect is associated with gut microbiota modulation publication-title: Nutrients doi: 10.3390/nu14245233 – volume: 24 start-page: 1526 year: 2023 ident: ref43 article-title: Pathophysiology of inflammatory bowel disease: innate immune system publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms24021526 – volume: 15 start-page: 2291164 year: 2023 ident: ref16 article-title: Bifidobacterium mechanisms of immune modulation and tolerance publication-title: Gut Microbes doi: 10.1080/19490976.2023.2291164 – volume: 63 start-page: 8048 year: 2023 ident: ref19 article-title: Bifidobacterium spp. as functional foods: a review of current status, challenges, and strategies publication-title: Crit. Rev. Food Sci. Nutr. doi: 10.1080/10408398.2022.2054934 – volume: 91 start-page: e13357 year: 2020 ident: ref48 article-title: Regulation of the intestinal barrier by nutrients: the role of tight junctions publication-title: Anim. Sci. J. doi: 10.1111/asj.13357 – volume: 20 start-page: 257 year: 2019 ident: ref53 article-title: Improved metagenomic analysis with Kraken 2 publication-title: Genome Biol. doi: 10.1186/s13059-019-1891-0 – volume: 104 start-page: 5273 year: 2020 ident: ref55 article-title: Lactobacillus Plantarum NA136 ameliorates nonalcoholic fatty liver disease by modulating gut microbiota, improving intestinal barrier integrity, and attenuating inflammation publication-title: Appl. Microbiol. Biotechnol. doi: 10.1007/s00253-020-10633-9 – volume: 42 start-page: 172 year: 2023 ident: ref35 article-title: Bifidobacterium adolescentis induces Decorin+ macrophages via TLR2 to suppress colorectal carcinogenesis publication-title: J. Exp. Clin. Cancer Res. doi: 10.1186/s13046-023-02746-6 – volume: 11 start-page: 819 year: 2019 ident: ref23 article-title: The preventive and curative effects of Lactobacillus reuteri NK33 and Bifidobacterium adolescentis NK98 on immobilization stress-induced anxiety/depression and colitis in mice publication-title: Nutrients doi: 10.3390/nu11040819 – volume: 402 start-page: 571 year: 2023 ident: ref31 article-title: Ulcerative colitis publication-title: Lancet doi: 10.1016/S0140-6736(23)00966-2 – volume: 11 start-page: 1649 year: 2023 ident: ref10 article-title: Bifidobacterium breve PRL2020: antibiotic-resistant profile and genomic detection of antibiotic resistance determinants publication-title: Microorganisms doi: 10.3390/microorganisms11071649 – volume: 20 start-page: 429 year: 2023 ident: ref52 article-title: Gut microbiota in colorectal cancer development and therapy publication-title: Nat. Rev. Clin. Oncol. doi: 10.1038/s41571-023-00766-x – volume: 184 start-page: 114759 year: 2023 ident: ref54 article-title: Evaluation of the safety and probiotic properties of Lactobacillus gasseri LGZ1029 based on whole genome analysis publication-title: LWT doi: 10.1016/j.lwt.2023.114759 – volume: 14 start-page: 3671 year: 2022 ident: ref42 article-title: Bifidobacterium breve alleviates DSS-induced colitis in mice by maintaining the mucosal and epithelial barriers and modulating gut microbes publication-title: Nutrients doi: 10.3390/nu14183671 – volume: 12 start-page: 741934 year: 2021 ident: ref51 article-title: Stigmasterol restores the balance of Treg/Th17 cells by activating the butyrate-PPARγ axis in colitis publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.741934 – volume: 2 start-page: 211 year: 2011 ident: ref26 article-title: Intestinal dysbiosis in inflammatory bowel disease publication-title: Gut Microbes doi: 10.4161/gmic.2.4.17863 – volume: 74 start-page: 13 year: 2015 ident: ref14 article-title: Links between diet, gut microbiota composition and gut metabolism publication-title: Proc. Nutr. Soc. doi: 10.1017/S0029665114001463 – volume: 12 start-page: 761981 year: 2021 ident: ref7 article-title: Interaction between commensal bacteria, immune response and the intestinal barrier in inflammatory bowel disease publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.761981 – volume: 17 start-page: 597 year: 2020 ident: ref29 article-title: Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/s41575-020-0331-7 – volume: 1 start-page: 15 year: 2012 ident: ref44 article-title: The intestinal microbiota in inflammatory bowel diseases publication-title: Am. J. Gastroenterol. Suppl. doi: 10.1038/ajgsup.2012.4 – volume: 10 start-page: 273 year: 2022 ident: ref5 article-title: Genome sequence and assessment of safety and potential probiotic traits of Lactobacillus johnsonii CNCM I-4884 publication-title: Microorganisms doi: 10.3390/microorganisms10020273 – volume: 13 start-page: 1 year: 2021 ident: ref11 article-title: B. adolescentis ameliorates chronic colitis by regulating Treg/Th2 response and gut microbiota remodeling publication-title: Gut Microbes doi: 10.1080/19490976.2020.1826746 – volume: 80 start-page: 37 year: 2021 ident: ref40 article-title: SCFA: mechanisms and functional importance in the gut publication-title: Proc. Nutr. Soc. doi: 10.1017/S0029665120006916 – volume: 3 start-page: e174 year: 2024 ident: ref37 article-title: Isolation of potentially novel species expands the genomic and functional diversity of Lachnospiraceae publication-title: iMeta doi: 10.1002/imt2.174 – volume: 79 start-page: 460 year: 2022 ident: ref21 article-title: 5-aminosalicylic acid ameliorates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota and bile acid metabolism publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-022-04471-3 – volume: 13 start-page: 1949096 year: 2021 ident: ref6 article-title: Dysbiotic microbiota interactions in Crohn’s disease publication-title: Gut Microbes doi: 10.1080/19490976.2021.1949096 – volume: 121 start-page: 1787 year: 1991 ident: ref13 article-title: Absorption of short-chain fatty acids from the rat cecum in vivo publication-title: J. Nutr. doi: 10.1093/jn/121.11.1787 – volume: 3 start-page: e104 year: 2016 ident: ref38 article-title: Bracken: estimating species abundance in metagenomics data publication-title: PeerJ Comput. Sci. doi: 10.1101/051813 – volume: 356 start-page: 1072 year: 2017 ident: ref4 article-title: Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells publication-title: Science doi: 10.1126/science.aai8132 – volume: 35 start-page: 193 year: 1977 ident: ref46 article-title: Molecular alterations of interferons publication-title: Tex. Rep. Biol. Med. – volume: 30 start-page: 124 year: 2022 ident: ref3 article-title: The mouse gastrointestinal bacteria catalogue enables translation between the mouse and human gut microbiotas via functional mapping publication-title: Cell Host Microbe doi: 10.1016/j.chom.2021.12.003 – volume: 24 start-page: 577 year: 2024 ident: ref39 article-title: Short-chain fatty acids: linking diet, the microbiome and immunity publication-title: Nat. Rev. Immunol. doi: 10.1038/s41577-024-01014-8 – volume: 21 start-page: 348 year: 2020 ident: ref24 article-title: Host DNA contents in fecal metagenomics as a biomarker for intestinal diseases and effective treatment publication-title: BMC Genomics doi: 10.1186/s12864-020-6749-z – volume: 14 start-page: 525 year: 2023 ident: ref33 article-title: Bifidobacterium adolescentis—a beneficial microbe publication-title: Benefic. Microbes doi: 10.1163/18762891-20230030 – volume: 14 start-page: 1211271 year: 2023 ident: ref20 article-title: Probiotics for the treatment of ulcerative colitis: a review of experimental research from 2018 to 2022 publication-title: Front. Microbiol. doi: 10.3389/fmicb.2023.1211271 – volume: 12 start-page: 1109 year: 2023 ident: ref8 article-title: Impact of Bifidobacterium longum NSP001 on DSS-induced colitis in conventional and humanised mice publication-title: Food Sci. Human Wellness doi: 10.1016/j.fshw.2022.10.028 – volume: 21 start-page: 103017 year: 2022 ident: ref41 article-title: The influence of cytokines on the complex pathology of ulcerative colitis publication-title: Autoimmun. Rev. doi: 10.1016/j.autrev.2021.103017 – volume: 36 start-page: 1525 year: 2013 ident: ref32 article-title: Antiviral activity of Bifidobacterium adolescentis SPM0212 against hepatitis B virus publication-title: Arch. Pharm. Res. doi: 10.1007/s12272-013-0141-3 – volume: 78 start-page: 1595 year: 2023 ident: ref47 article-title: Early infancy dysbiosis in food protein-induced enterocolitis syndrome: a prospective cohort study publication-title: Allergy doi: 10.1111/all.15644 – volume: 6 start-page: gix050 year: 2017 ident: ref18 article-title: Two distinct metacommunities characterize the gut microbiota in Crohn’s disease patients publication-title: GigaScience doi: 10.1093/gigascience/gix050 – volume: 29 start-page: 625 year: 2005 ident: ref2 article-title: The interaction between bacteria and bile publication-title: FEMS Microbiol. Rev. doi: 10.1016/j.femsre.2004.09.003 – volume: 2020 start-page: baaa055 year: 2020 ident: ref17 article-title: CNSA: a data repository for archiving omics data publication-title: Database doi: 10.1093/database/baaa055 – volume: 303 start-page: 27 year: 2013 ident: ref22 article-title: Dynamics and regulation of epithelial adherens junctions: recent discoveries and controversies publication-title: Int. Rev. Cell Mol. Biol. doi: 10.1016/B978-0-12-407697-6.00002-7 – volume: 4 start-page: 293 year: 2018 ident: ref15 article-title: Gut microbiome structure and metabolic activity in inflammatory bowel disease publication-title: Nat. Microbiol. doi: 10.1038/s41564-018-0306-4 – volume: 14 start-page: 1663 year: 2023 ident: ref36 article-title: The genomic landscape of reference genomes of cultivated human gut bacteria publication-title: Nat. Commun. doi: 10.1038/s41467-023-37396-x – volume: 13 start-page: 9999 year: 2022 ident: ref49 article-title: Preventive effect of pectic oligosaccharides on acute colitis model mice: modulating epithelial barrier, gut microbiota and Treg/Th17 balance publication-title: Food Funct. doi: 10.1039/d2fo01448c – volume: 37 start-page: 179 year: 2019 ident: ref56 article-title: 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses publication-title: Nat. Biotechnol. doi: 10.1038/s41587-018-0008-8 – volume: 231 start-page: 713 year: 1985 ident: ref1 article-title: Fuel utilization in colonocytes of the rat publication-title: Biochem. J. doi: 10.1042/bj2310713 – volume: 18 start-page: 489 year: 2015 ident: ref34 article-title: Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohn’s disease publication-title: Cell Host Microbe doi: 10.1016/j.chom.2015.09.008 – volume: 32 start-page: 507 year: 2023 ident: ref27 article-title: A review on the use of prebiotics in ulcerative colitis publication-title: Trends Microbiol. doi: 10.1016/j.tim.2023.11.007 – volume: 9 start-page: 18880 year: 2019 ident: ref28 article-title: Differences in the intestinal microbiome of healthy children and patients with newly diagnosed Crohn’s disease publication-title: Sci. Rep. doi: 10.1038/s41598-019-55290-9 – volume: 158 start-page: 930 year: 2020 ident: ref9001 article-title: Differences in Gut Microbiota in Patients With vs Without Inflammatory Bowel Diseases: A Systematic Review publication-title: Gastroenterology doi: 10.1053/j.gastro.2019.11.294 – volume: 42 start-page: 799 year: 2020 ident: ref9 article-title: CNGBdb: China National GeneBank DataBase publication-title: Yi Chuan doi: 10.16288/j.yczz.20-080 |
| SSID | ssj0000402000 |
| Score | 2.394047 |
| Snippet | Numerous studies have confirmed that gut microbiota is a key driver in the occurrence and progression of inflammatory bowel disease (IBD). Based on the... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | 1496280 |
| SubjectTerms | Bifidobacterium adolescentis genomic analysis inflammatory bowel disease intestinal barrier function Microbiology probiotic function |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3PSx0xEA5FEHopamu72pYIvcnSbDbJS461aKWgJwVvIT_pHtwV3Xfw5p_uTHbV90qhF6-bDTvkm8zMxybfEPLNNS4Y7he1yoHXwi1gz2ml60UQwaB-VlZ43_nsXJ1eit9X8mql1ReeCZvkgaeF-94kHzj3KuqFFqKNmicgVSY7l5XMLGH0hZy3QqZKDEZaxNh0SwZYmAGYuuCBD3IBwcEojjqQK5moCPb_q8r8-7DkSvY52SLv5rKR_pjM3SZvUr9DNqdGkvfvycOv1A_XibpZYoQOmR51uYuwW4sa8_Kavmg3wbjrI-1eJDaGHmd04x2dz3dQeAK-B-4yXW2cJ4w4AQ3x7hZb3VFMizj-gVyeHF_8PK3n3gp1EJyNtWfcOGeYSDJziDG-VVFG7lhrZOtFlCb6DFQvZsmTSzKBuUB-fDBCsxBiu0s2-qFPnwg12QAc0Tuhsmi084WFAA1hWsSkdUUOn9bZ3kwSGhaoB6JiCyoWUbEzKhU5Qiie30T56_IAnMLOTmH_5xQVOXgC0sJ2wX8grk_D8s62WH8qZbisyMcJ2OdPQa3WNFBxVUSvQb5my_pI3_0pktxFaA-Y5N5rWL9P3nLsMsyamvPPZGO8XaYvUPqM_mvx8kdvOQZ2 priority: 102 providerName: Directory of Open Access Journals |
| Title | Genome analysis of Bifidobacterium adolescentis and investigation of its effects on inflammation and intestinal barrier function |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/39911710 https://www.proquest.com/docview/3163866925 https://pubmed.ncbi.nlm.nih.gov/PMC11794259 https://doaj.org/article/1ebc22b6d878443d82e3839faaf65f0e |
| Volume | 15 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Nb9QwELWqVkhcEOVzoVRG4oaCEsdx7ANCLaKtkMqJlfZm-RMi0QR2s1J7609nxvG2LCoHLjnEcTLx82TmJfEbQt6YyjjFbFuI6FjBTQs-J4UsWsedQv2sKHC98_kXcTbnnxfNYodsyh3lAVzdSe2wntR8-ePd5a-rD-Dw75FxQrwFBDpngeoxDn6vBJNA4fcgMrXoqOc53U9PZiRLaVVKJQR-EGCLaR3NP06zFauSpP9deejfv1P-EZ9OHpIHObGkR9NM2Cc7oX9E7k2lJq8ek-vT0A8XgZosQkKHSI-72Hnw56TXvL6gt-pO0G56T7tbEY6hxx7duKL5DxAKe2C8YEJNix9zhxE7oCHWLLEYHsXAie1PyPzk09ePZ0WuvlA4zsqxsCVTxqiShyYyeArZWvjGM1PWqqkt943yNgIZ9LFhwYQmgLlAj6xTXJbO-fop2e2HPjwnVEWlovHWcBF5JY1NPAWISim5D1LOyNvNOOufk8iGBnKCqOiEikZUdEZlRo4RipsjUSA77RiW33T2N10F6xizwstWcl57yQJwcbDCRNHEMszI6w2QGhwKv5KYPgzrla4xQxVCsWZGnk3A3lwKsrkKphWYILcg37Jlu6XvvifR7iTFB1zzxX_d60tyn2HB4bIqGDsgu-NyHV5BFjTaw_T2ALani-owTfPfuFUJsw |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genome+analysis+of+Bifidobacterium+adolescentis+and+investigation+of+its+effects+on+inflammation+and+intestinal+barrier+function&rft.jtitle=Frontiers+in+microbiology&rft.au=Li%2C+Bo&rft.au=Wang%2C+Haoyu&rft.au=Wang%2C+Mengmeng&rft.au=Liang%2C+Hewei&rft.date=2025-01-22&rft.issn=1664-302X&rft.eissn=1664-302X&rft.volume=15&rft_id=info:doi/10.3389%2Ffmicb.2024.1496280&rft.externalDBID=n%2Fa&rft.externalDocID=10_3389_fmicb_2024_1496280 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-302X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-302X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-302X&client=summon |