Comparative analysis of clinical and immunological profiles across Omicron BA.5.2 subvariants using next-generation sequencing in a Chinese cohort

• Published in: Frontiers in cellular and infection microbiology Vol. 13; p. 1288914
• Main Authors: Huang, Jianliang, Xia, Mingkai, Liu, Rangjiao, Wang, Shaobo, Duan, Xinyi, Peng, Jiong, Li, Enping, Zhou, Yanping, Li, Chengyou, Zhang, Quan, Tian, Jixian, Wang, Xinjian, Su, Zhongrui, Tan, Jun, Peng, Bo, Zhang, Jianhui, Li, Jin, Dai, Lizhong, Lei, Mingsheng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 30.10.2023
• Subjects: Cellular and Infection Microbiology; clinical characteristic; COVID-19 - immunology; COVID-19 - virology; Critical Illness; disease severity; East Asian People; High-Throughput Nucleotide Sequencing; Humans; immune function; mutation sites; NGS; Omicron subvariants; SARS-CoV-2 - genetics; NGS; Omicron subvariants; mutation sites; clinical characteristic; disease severity; immune function

The Omicron BA.5.2 variant of SARS-CoV-2 has undergone several evolutionary adaptations, leading to multiple subvariants. Rapid and accurate characterization of these subvariants is essential for effective treatment, particularly in critically ill patients. This study leverages Next-Generation Seque...