Neural substrates of inhibitory control deficits in 22q11.2 deletion syndrome

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 25; no. 4; pp. 1069 - 1079
• Main Authors: Montojo, C A, Jalbrzikowski, M, Congdon, E, Domicoli, S, Chow, C, Dawson, C, Karlsgodt, K H, Bilder, R M, Bearden, C E
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.04.2015
• Subjects: Adolescent; Adult; Brain - physiopathology; DiGeorge Syndrome - physiopathology; Female; Humans; Inhibition, Psychological; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Psychiatric Status Rating Scales; Psychomotor Performance - physiology; Severity of Illness Index; Young Adult; impulsivity; velocardiofacial syndrome; fronto-basal ganglia; response inhibition

22q11.2 deletion syndrome (22q11DS) is associated with elevated levels of impulsivity, inattention, and distractibility, which may be related to underlying neurobiological dysfunction due to haploinsufficiency for genes involved in dopaminergic neurotransmission (i.e. catechol-O-methyltransferase)....