Expression of CHRFAM7A and CHRNA7 in neuronal cells and postmortem brain of HIV-infected patients: considerations for HIV-associated neurocognitive disorder

• Published in: Journal of neurovirology Vol. 22; no. 3; pp. 327 - 335
• Main Authors: Ramos, Félix M., Delgado-Vélez, Manuel, Ortiz, Ángel L., Báez-Pagán, Carlos A., Quesada, Orestes, Lasalde-Dominicci, José A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2016
• Subjects: Adult; AIDS Dementia Complex - genetics; AIDS Dementia Complex - metabolism; AIDS Dementia Complex - pathology; AIDS Dementia Complex - virology; alpha7 Nicotinic Acetylcholine Receptor - genetics; alpha7 Nicotinic Acetylcholine Receptor - metabolism; Autopsy; Basal Ganglia - metabolism; Basal Ganglia - pathology; Basal Ganglia - virology; Biomedical and Life Sciences; Biomedicine; Brain - metabolism; Brain - pathology; Brain - virology; Cell Death - drug effects; Cell Line, Tumor; Female; Gene Expression Regulation; HIV Envelope Protein gp120 - genetics; HIV Envelope Protein gp120 - metabolism; HIV Envelope Protein gp120 - pharmacology; HIV-1 - genetics; HIV-1 - metabolism; HIV-1 - pathogenicity; Host-Pathogen Interactions; Human immunodeficiency virus 1; Humans; Immunology; Infectious Diseases; Lentivirus; Male; Middle Aged; Neurology; Neurons - cytology; Neurons - drug effects; Neurons - metabolism; Neurosciences; Retroviridae; Severity of Illness Index; Signal Transduction; Virology; gp120; CHRFAM7A; HIV; CHRNA7; HAND; Nicotinic acetylcholine receptor

Despite the recent advances in antiretroviral therapy, human immunodeficiency virus type 1 (HIV-1) remains a global health threat. HIV-1 affects the central nervous system by releasing viral proteins that trigger neuronal death and neuroinflammation, and promotes alterations known as HIV-associated...