Cymensifin A: a promising pharmaceutical candidate to defeat lung cancer via cellular reactive oxygen species-mediated apoptosis

• Published in: Frontiers in pharmacology Vol. 15; p. 1361085
• Main Authors: Soares, Bruno Cesar Costa, Khine, Hnin Ei Ei, Sritularak, Boonchoo, Chanvorachote, Pithi, Alduina, Rosa, Sungthong, Rungroch, Chaotham, Chatchai
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 11.04.2024
• Subjects: apoptosis; Cymensifin A; DNA damage; lung cancer; mitochondrial outer membrane permeabilization; Pharmacology; ROS; lung cancer; Cymensifin A; DNA damage; ROS; apoptosis; mitochondrial outer membrane permeabilization; orchid

The upgrade of natural products for cancer treatment is essential since current anticancer drugs still pose severe side effects. Cymensifin A (Cym A) isolated from an orchid Cymbidium ensifolium has shown its potential to induce the death of several cancer cells; however, its underlying molecular me...