The role of mesenchymal cells in the pathophysiology of inflammatory arthritis

• Published in: Best practice & research. Clinical rheumatology Vol. 20; no. 5; pp. 969 - 981
• Main Authors: Meyer, Lars-Henrik, Franssen, Lars, Pap, Thomas
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.10.2006
• Subjects: activation; Antigens, CD - metabolism; apoptosis; Apoptosis - physiology; Arthritis, Rheumatoid - immunology; Arthritis, Rheumatoid - metabolism; Arthritis, Rheumatoid - pathology; Arthritis, Rheumatoid - physiopathology; attachment; Cartilage, Articular - metabolism; Cytokines - metabolism; Extracellular Matrix - pathology; extracellular matrix degradation; Fas; fas Receptor - immunology; fibroblast-like synoviocytes; Fibroblasts; Humans; Hyperplasia; Integrins - metabolism; matrix metalloproteinases; Matrix Metalloproteinases - physiology; Mesoderm - cytology; Synovial Membrane - cytology; Tumor Necrosis Factor-alpha - immunology; attachment; fibroblast-like synoviocytes; hyperplasia; apoptosis; Fas; activation; extracellular matrix degradation; matrix metalloproteinases

Rheumatoid arthritis (RA) is a chronic inflammatory disorder of the joints that can cause severe disability. While the role of inflammatory cells in the pathogenesis of RA has been well established, the specific contribution of resident cells within the synovial membrane, especially those of mesench...