A Nationwide Study on the Seroprevalence of Measles, Mumps, and Rubella in Iranian Children and Adolescents

Background: Assessing the prevalence of infections, which are preventable by vaccination, is crucial to monitor the vaccination program efficacy, and it can demonstrate the gaps in population immunity. The current study attempted to assess the specific Immunoglobulin (IgG) antibody against measles,...

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Published inIranian journal of public health Vol. 51; no. 2; pp. 409 - 415
Main Authors Nokhodian, Zary, Ataei, Behrooz, Gouya, Mohammad Mehdi, Ghaffari Hoseini, Shervin, Yaran, Majid, Mansourian, Marjan, Esmaeil Motlagh, Mohammad, Heshmat, Ramin, Zahraei, Seyed Mohsen, Kelishadi, Roya
Format Journal Article
LanguageEnglish
Published Tehran Tehran University of Medical Sciences 01.02.2022
Subjects
Adolescents
Children
Enzyme-linked immunosorbent assay
Herd immunity
IgG antibody
Immunoglobulin G
Iran
Measles
Mumps
Original
Population studies
Rubella
Serology
Teenagers
Vaccination
Iran
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Summary:Background: Assessing the prevalence of infections, which are preventable by vaccination, is crucial to monitor the vaccination program efficacy, and it can demonstrate the gaps in population immunity. The current study attempted to assess the specific Immunoglobulin (IgG) antibody against measles, mumps, and rubella (MMR) in Iranian children and adolescents, years after their vaccination. Methods: This cross-sectional study was conducted in Iran. Serum samples of 2100 students, aged 7-18 years, included in a national health survey, were tested for MMR antibodies by ELISA assay. Multistage random cluster sampling was used to select subjects from 30 provinces in Iran. Results: Overall, 1871, 1718, and 1678 serums were tested for measles, mumps, and rubella antibodies, respectively. The prevalence of positive test was 1231 (65.8%) for measles, 1327 (77.2%) for mumps and 1344 (80.1%) for rubella. Conclusion: Despite high vaccination coverage in Iran, IgG antibody against measles, mumps, and rubella was not detected in a considerable proportion of children and adolescents aged 7-18 years. In case of contacts with residents of other countries, where measles or rubella have not yet been eliminated, it may create problems for Iranian children.  
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ISSN:2251-6085
2251-6093
2251-6093
DOI:10.18502/ijph.v51i2.8694