Serum and tear autoantibodies from NOD and NOR mice as potential diagnostic indicators of local and systemic inflammation in Sjögren’s disease

• Published in: Frontiers in immunology Vol. 15; p. 1516330
• Main Authors: Singh Kakan, Shruti, Abdelhamid, Sara, Ju, Yaping, MacKay, J. Andrew, Edman, Maria C., Raman, Indu, Zhu, Chengsong, Raj, Prithvi, Hamm-Alvarez, Sarah F.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 28.01.2025
• Subjects: Animals; Autoantibodies - blood; Autoantibodies - immunology; Autoantigens - immunology; autoimmune disease; Biomarkers; Dacryocystitis - immunology; Disease Models, Animal; IgA autoantibodies; IgG autoantibodies; Immunoglobulin A - immunology; Immunoglobulin G - immunology; Immunology; Inflammation - diagnosis; Inflammation - immunology; Lacrimal Apparatus - immunology; Male; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Salivary Glands - immunology; serum; Sjogren's Syndrome - blood; Sjogren's Syndrome - diagnosis; Sjogren's Syndrome - immunology; Sjögren’s disease; tear film; Tears - immunology; tear film; IgA autoantibodies; serum; Sjögren’s disease; autoimmune disease; IgG autoantibodies

Sjögren's Disease (SjD) is an autoimmune disease characterized by lymphocytic infiltration of salivary and lacrimal glands (LG). The LG produces the protein-rich aqueous component of tears, and SjD-associated autoimmune dacryoadenitis (AD) may thus alter tear autoantibody composition. The prese...