The effects of chronic administration of stimulant and non-stimulant medications on executive functions in ADHD: A systematic review and meta-analysis

• Published in: Neuroscience and biobehavioral reviews Vol. 162; p. 105703
• Main Authors: Isfandnia, Ferdous, El Masri, Sahid, Radua, Joaquim, Rubia, Katya
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.07.2024
• Subjects: ADHD; Atomoxetine; Atomoxetine Hydrochloride - administration & dosage; Attention; Attention Deficit Disorder with Hyperactivity - diagnosis; Attention Deficit Disorder with Hyperactivity - drug therapy; Attention Deficit Disorder with Hyperactivity - physiopathology; Central Nervous System Stimulants - administration & dosage; Cognitive function; Executive Function - drug effects; Executive Function - physiology; Executive functions; Humans; Inhibition; Memory, Short-Term - drug effects; Memory, Short-Term - physiology; Methylphenidate; Methylphenidate - administration & dosage; Non-stimulant medication; Reaction time, reaction time variability, meta-analysis; Stimulant medication; Systematic review; Working memory; ADHD; Atomoxetine; Non-stimulant medication; Stimulant medication; Reaction time, reaction time variability, meta-analysis; Attention; Executive functions; Systematic review; Working memory; Inhibition; Cognitive function; Methylphenidate

Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with executive function deficits that are improved with medications. However, meta-analyses of stimulant effects on cognition have mostly tested single-dose effects, and there is no meta-analysis of non-stimulant effects. This systematic...