Oxidative stress-mediated abnormal polarization of decidual macrophages promotes the occurrence of atonic postpartum hemorrhage

• Published in: Redox biology Vol. 81; p. 103530
• Main Authors: Qu, Jiangxue, Jiang, Hai, Zhang, Boyang, Shi, Huifeng, Zeng, Shuai, Wang, Wei, Chen, Lian, Zhao, Yangyu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2025; Elsevier
• Subjects: Adult; Animals; Atonic postpartum hemorrhage; Cytokines; Cytokines - metabolism; Decidua - metabolism; Decidua - pathology; Female; Humans; Hydrogen Peroxide; Macrophage polarization; Macrophages - immunology; Macrophages - metabolism; Macrophages - pathology; Oxidative Stress; Postpartum Hemorrhage - etiology; Postpartum Hemorrhage - metabolism; Postpartum Hemorrhage - pathology; Pregnancy; Reactive Oxygen Species - metabolism; Uterine contraction-associated proteins; CD86; Basic FGF; M-CSF; RANTES; Uterine contraction-associated proteins; H2O2; OTR; TNF; CTACK; GDM; α-SMA; Arg-1; GM-CSF; GRO-a; KEGG; iNOS; CAPs; IL; TRAIL; Macrophage polarization; Cytokines; GPX3; MMP2; HGF; MIG; MMP9; G-CSF; MIP; ROS; β-NGF; NK; Oxidative stress; TAGLN; COX-2; Atonic postpartum hemorrhage; uSMCs; PPH; T cells; IFN; HDP; SDF-1α; CCL-2; BMI; 8-OHdG; GO; LIF; SOD; TNF-α; SCF; CD206; MCP

Postpartum hemorrhage (PPH) is the leading cause of maternal mortality worldwide. However, the mechanism underlying atonic PPH remains partially elucidated. Multi-omics revealed that differentially expressed proteins and metabolites were enriched in the immune-inflammation pathway in the vaginal blo...