The therapeutic mechanism of transcranial iTBS on nerve regeneration and functional recovery in rats with complete spinal cord transection

• Published in: Frontiers in immunology Vol. 14; p. 1153516
• Main Authors: Liu, Jia-Lin, Wang, Shuai, Chen, Zheng-Hong, Wu, Rong-Jie, Yu, Hai-Yang, Yang, Shang-Bin, Xu, Jing, Guo, Yi-Nan, Ding, Ying, Li, Ge, Zeng, Xiang, Ma, Yuan-Huan, Gong, Yu-Lai, Wu, Chuang-Ran, Zhang, Li-Xin, Zeng, Yuan-Shan, Lai, Bi-Qin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.06.2023
• Subjects: Animals; Gastropoda; Immunology; intermittent theta-burst stimulation (iTBS); motor pathway; Nerve Regeneration; neuroprotection; Neuroprotective Agents; Rats; Serotonin; Spinal Cord Injuries - therapy; spinal cord injury; synaptic plasticity; spinal cord injury; nerve regeneration; motor pathway; synaptic plasticity; intermittent theta-burst stimulation (iTBS); neuroprotection

After spinal cord transection injury, the inflammatory microenvironment formed at the injury site, and the cascade of effects generated by secondary injury, results in limited regeneration of injured axons and the apoptosis of neurons in the sensorimotor cortex (SMC). It is crucial to reverse these...