Establishment and immune phenotyping of patient-derived glioblastoma models in humanized mice

• Published in: Frontiers in immunology Vol. 14; p. 1324618
• Main Authors: Liu, Longsha, van Schaik, Thijs A, Chen, Kok-Siong, Rossignoli, Filippo, Borges, Paulo, Vrbanac, Vladimir, Wakimoto, Hiroaki, Shah, Khalid
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 11.01.2024
• Subjects: Adult; Animals; BLT humanized mice; Brain Neoplasms; Disease Models, Animal; flow cytometry; GBM - multiforme; Glioblastoma - therapy; hGBM; humanized mice; Humans; Immunology; Mice; multiplex immunofluorescence staining; Neoplasm Recurrence, Local - pathology; Neoplastic Stem Cells - pathology; Tumor Microenvironment; GBM - multiforme; flow cytometry; hGBM; BLT humanized mice; multiplex immunofluorescence staining; humanized mice

Glioblastoma (GBM) is the most aggressive and common type of malignant brain tumor diagnosed in adults. Preclinical immunocompetent mouse tumor models generated using mouse tumor cells play a pivotal role in testing the therapeutic efficacy of emerging immune-based therapies for GBMs. However, the c...