The role and mechanism of pyroptosis and potential therapeutic targets in non-alcoholic fatty liver disease (NAFLD)

• Published in: Frontiers in cell and developmental biology Vol. 12; p. 1407738
• Main Authors: Li, Shu-Jing, Liu, An-Bu, Yu, Yuan-Yuan, Ma, Jin-Hai
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 03.07.2024
• Subjects: caspase; Cell and Developmental Biology; gasdermin D (GSDMD); NOD-like receptor thermal protein domain associated protein 3(NLRP3) inflammasome; non-alcoholic fatty liver disease (NAFLD); pyroptosis; targeted therapy; non-alcoholic fatty liver disease (NAFLD); gasdermin D (GSDMD); pyroptosis; targeted therapy; NOD-like receptor thermal protein domain associated protein 3(NLRP3) inflammasome; caspase

Non-alcoholic fatty liver disease (NAFLD) is a clinical pathological syndrome characterized by the excessive accumulation of fat within liver cells, which can progress to end-stage liver disease in severe cases, posing a threat to life. Pyroptosis is a distinct, pro-inflammatory form of cell death,...