Progressive impairment of brain oxidative metabolism reversed by reperfusion following middle cerebral artery occlusion in anaesthetized baboons

• Published in: Brain research Vol. 767; no. 1; pp. 17 - 25
• Main Authors: Touzani, Omar, Young, Alan R, Derlon, Jean-Michel, Baron, Jean-Claude, MacKenzie, Eric T
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 29.08.1997
• Subjects: Analysis of Variance; Animals; Arterial Occlusive Diseases - therapy; Baboon; Brain - metabolism; Cerebral Arterial Diseases - therapy; Cerebral ischemia; Disease Progression; Infarction; Linear Models; Male; Neuroprotection; Oxidation-Reduction; Oxidative metabolism; Papio; Positron emission tomography; Reperfusion; Stroke; Tomography, Emission-Computed; Neuroprotection; Cerebral ischemia; Stroke; Reperfusion; Oxidative metabolism; Infarction; Positron emission tomography; Baboon

A better understanding of the temporospatial evolution of ischaemic brain tissue towards necrosis would be of crucial value to establish and validate therapeutic strategies for stroke in man. By means of sequential positron emission tomographic (PET) studies performed through the acute to the chroni...